Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6874 - 6874
Published: Nov. 15, 2024
Psoriasis is a chronic inflammatory skin disease with complex pathogenesis and variable severity. Performed studies have indicated the impact of vitamin D3 deficiency on psoriasis its However, there no clear evidence influence mucosal microbiome onset progression psoriasis. This review aims to present current role colonization oral mucosa by
Language: Английский
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 582 - 582
Published: Jan. 17, 2025
Psoriasis is a chronic, immune-mediated skin disease significantly impacting women, with severity often modulated by hormonal fluctuations. This review examines the influence of changes on course psoriasis in focusing key life stages—including menstrual cycle, pregnancy, postpartum, and menopause—and their impact progression symptomatology. Estrogen, principal female sex hormone, plays critical role immune modulation. Variations estrogen levels, which occur naturally throughout woman’s life, are associated fluctuations severity. Low as seen during menstruation or menopause, linked to symptom exacerbation, while elevated levels pregnancy may reduce symptoms some women. However, responses variable, others experiencing no change worsening pregnancy. Postpartum, rapid decline triggers severe flare-ups, marked sustained reduction, frequently correlates increased flare frequency. The also addresses profound women’s quality including physical discomfort, psychological distress, social stigma. Additionally, fertility concerns discussed, treatments increase risk adverse outcomes. Consideration given therapies, lifestyle modifications, effects psoriasis, underscoring need for personalized treatment approaches that account influences. Understanding these dynamics essential developing targeted, effective management strategies enhance women affected psoriasis.
Language: Английский
Citations
2
Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: Jan. 4, 2025
Language: Английский
Citations
1
Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: Feb. 22, 2025
Language: Английский
Citations
1
Medicina, Journal Year: 2023, Volume and Issue: 59(11), P. 2006 - 2006
Published: Nov. 15, 2023
Background and Objectives: Psoriasis is a common, chronic, immune-mediated inflammatory skin disease recognized to lead wide range of comorbid disorders, mainly obesity. The study aimed evaluate the problem overweightness obesity among psoriasis patients in context their prevalence influence on course. Materials Methods: group encompassed 147 adult with plaque psoriasis. Results: prevalences (39.46%) (37.41%) demonstrated showed strong predisposition psoriatic for abnormal body mass. vast majority (77%) subjects arthritis were overweight or obese. results correlation analysis revealed significant impacts obesity, as defined by BMI index, modifying severity (as assessed PASI coefficient R = 0.23, p 0.016; BSA values 0.21, 0.023), particularly contrast normal Conclusions: Overweightness constitute major health burden patients, influencing course severity. Enhanced understanding phenomenon may directly translate into improving management overall patient care.
Language: Английский
Citations
14
Nutrients, Journal Year: 2024, Volume and Issue: 16(1), P. 160 - 160
Published: Jan. 3, 2024
In the context of nutrient-driven epigenetic alterations, food-derived miRNAs can be absorbed into circulatory system and organs recipients, especially humans, potentially contribute to modulating health diseases. Evidence suggests that food uptake, by carrying exogenous (xenomiRNAs), regulates individual miRNA profile, modifying redox homeostasis inflammatory conditions underlying pathological processes, such as type 2 diabetes mellitus, insulin resistance, metabolic syndrome, cancer. The capacity diet control levels comprehension unique characteristics dietary in terms gene expression regulation show important perspectives a strategy disease susceptibility via modifications refine clinical outcomes. However, absorption, stability, availability, roles are intriguing currently subject intense debate; additionally, there is restricted knowledge their physiological potential side effects. Within this framework, we provided up-to-date comprehensive on miRNAs’ potential, discussing latest advances controversial issues related role human modulators chronic syndromes.
Language: Английский
Citations
6
Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14
Published: June 22, 2023
Cumulative evidence showed an association between gut microbiota and urticaria, but the causal relationship them is unclear. We aimed to verify whether there a composition of urticaria explore effect was bidirectional.We obtained genome-wide studies (GWAS) summary data 211 from most extensive available GWAS database. A bidirectional two-sample mendelian randomization (MR) study used test urticaria. The MR analysis primarily performed with inverse variance weighted (IVW) method, MR-Egger, median (WM), MR-PRESSO were as sensitivity analyses.The Phylum Verrucomicrobia (OR 1.27, 95%CI 1.01 1.61; p = 0.04), Genus Defluviitaleaceae UCG011 1.29, 1.04 1.59; 0.02), Coprococcus 3 1.44, 1.02 2.05; 0.04) risk against And Order Burkholderiales 0.68, 0.49 0.99; Eubacterium xylanophilum group 0.78, 0.62 negatively associated suggesting protective effect. At same time, had positively on (Genus coprostanoligenes group) 1.08, 1.16; 0.02). These findings no influence by heterogeneity or horizontal pleiotropy. Moreover, analyses results consistent those IVW analysis.Our confirmed potential bidirectional. Nevertheless, these warrant further examination owing unclear mechanisms.
Language: Английский
Citations
11
Dermatology Practical & Conceptual, Journal Year: 2025, Volume and Issue: 15(1), P. 4805 - 4805
Published: Jan. 29, 2025
Introduction: Psoriasis is a chronic immune-mediated skin condition. One of the intriguing challenges in studying psoriasis has been identification correlations between this disease and gender body weight. Objective: A multicenter retrospective study was conducted among patients with moderate-to-severe who attended outpatient clinics 6 University Hospitals Italy. The effects apremilast on weight mass index (BMI) according to after 24 weeks 48 therapy were considered. Methods: We enrolled retrospectively 120 adult underwent treatment for at least weeks. Baseline characteristics, including age, gender, area severity (PASI), comorbidities, smoking alcohol habits, relevant medical history previous systemic biologic treatments recorded. Weight evaluated baseline (T0) (w24) (w48). descriptive statistical analysis performed. Results: showed significant reduction females w24 w48 (p < 0.001), mean difference −2.6 kg -5.7 w48. observed 3.6% w24, 7.9% Similar assessments also BMI, which reduced women by 8% In men, no changes BMI and/or Conclusion: Understanding interplay psoriasis, essential effective management improving patient outcomes.
Language: Английский
Citations
0
Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)
Published: March 6, 2025
In this narrative review, we provide an overview of how adherence to a Mediterranean dietary pattern can complement traditional treatment strategies for psoriasis, acne, and hidradenitis suppurativa. We emphasize the importance integrated approach, with interventions as key component holistic patient care. Psoriasis, suppurativa are immune-mediated chronic diseases marked by systemic inflammation, genetic environmental factors influencing their onset. The diet, rich in plant-based foods antioxidant anti-inflammatory properties-such whole-grain cereals, extra-virgin olive oil, vegetables, legumes, fruits, nuts-has been shown reduce clinical severity these conditions. It also supports weight control positively impacts metabolic cardiovascular risk factors, which closely linked diseases. Dietary education, particularly about plays crucial role management skin serves important non-pharmacological option that influence prognosis. This review offers specific nutrition recommendations prescribing diet patients inflammatory
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2895 - 2895
Published: March 22, 2025
Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17, and IL-23, play pivotal roles in the pathogenesis of psoriasis. Emerging evidence suggests that dietary interventions can modulate activity, providing complementary approach to standard therapies. This narrative review examines impact various strategies, Mediterranean diet, ketogenic gluten-free fasting-mimicking on profiles clinical outcomes Research insights reveal components such as omega-3 fatty acids, polyphenols, short-chain acids influence immune signaling pathways. These pathways include nuclear factor-kappa B (NF-κB) Signal Transducer Activator Transcription 3 (STAT3). Additionally, these promote anti-inflammatory effects mediated gut microbiota. Clinical studies demonstrate significant reductions psoriasis severity, improved quality life, modulation key cytokines associated with activity. Despite advancements, challenges persist effectively integrating findings into practice. variability patient responses, adherence issues, need for robust biomarkers monitor efficacy. Future directions emphasize potential personalized nutrition precision medicine approaches optimize tailored individual genetic predispositions. Integrating strategies care could transform treatment paradigms simultaneously addressing both systemic inflammation comorbid conditions.
Language: Английский
Citations
0
Frontiers in Bioscience-Landmark, Journal Year: 2025, Volume and Issue: 30(3)
Published: March 19, 2025
Psoriasis has been a rising concern for over decade, imposing significant challenges to individuals and society. Traditional topical therapy is non-targeted acts systemically, with associated side effects. This increases the global burden both socially economically. review covers evolution of drug molecules nanotechnology-based approaches treatment psoriasis, chronic inflammatory skin disorder no known etiology. Nanotechnology-based offer promising solutions by reducing effects, providing targeted delivery, protecting from degradation, enhancing retention, controlled release. Researchers have investigated incorporation various conventional non-conventional therapeutic agents into nanocarriers psoriasis treatment. The current understanding disease its using combined novel formulation strategies will reduce duration improve quality life in psoriatic conditions.
Language: Английский
Citations
0