Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(5), P. 3763 - 3793
Published: April 23, 2024
This
study
explores
a
nanoemulsion
formulated
with
açaí
seed
oil,
known
for
its
rich
fatty
acid
composition
and
diverse
biological
activities.
aimed
to
characterise
oil
explore
cytotoxic
effects
on
HeLa
SiHa
cervical
cancer
cell
lines,
alongside
assessing
antioxidant
toxicity
properties
both
in
vitro
vivo.
Extracted
from
fruits
sourced
Brazil,
the
underwent
thorough
chemical
characterization
using
gas
chromatography–mass
spectrometry.
The
resulting
was
prepared
evaluated
stability,
particle
size,
properties.
exhibited
translucency,
fluidity,
stability
post
centrifugation
temperature
tests,
droplet
size
of
238.37,
PDI
-9.59,
pH
7,
turbidity
0.267.
In
assessments
lines
revealed
antitumour
effects,
including
inhibition
proliferation,
migration,
colony
formation.
Toxicity
tests
conducted
cultures
female
Swiss
mice
demonstrated
no
adverse
nanoemulsion.
Overall,
particularly
when
into
nanoemulsion,
presents
potential
treatment
due
bioactive
safety
profile.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(3), P. 574 - 574
Published: March 5, 2024
Neurodegeneration
poses
a
significant
challenge
for
the
fields
of
neuroscience
and
medicine,
as
it
is
underlying
cause
development
advancement
numerous
neurodegenerative
psychiatric
disorders
[...]
Metabolites,
Journal Year:
2025,
Volume and Issue:
15(2), P. 124 - 124
Published: Feb. 13, 2025
Neurodegenerative
diseases
comprise
a
group
of
chronic,
usually
age-related,
disorders
characterized
by
progressive
neuronal
loss,
deformation
structure,
or
loss
function,
leading
to
substantially
reduced
quality
life.
They
remain
significant
focus
scientific
and
clinical
interest
due
their
increasing
medical
social
importance.
Most
neurodegenerative
present
intracellular
protein
aggregation
extracellular
deposition
(plaques),
such
as
α-synuclein
in
Parkinson's
disease
amyloid
beta
(Aβ)/tau
aggregates
Alzheimer's.
Conventional
treatments
for
conditions
incur
high
costs
are
related
the
development
several
adverse
effects.
In
addition,
many
patients
irresponsive
them.
For
these
reasons,
there
is
growing
tendency
find
new
therapeutic
approaches
help
patients.
This
review
intends
investigate
some
phytocompounds'
effects
on
diseases.
These
generally
increased
oxidative
stress
inflammation,
so
phytocompounds
can
prevent
treat
To
achieve
our
aim
provide
critical
assessment
current
literature
about
phytochemicals
targeting
neurodegeneration,
we
reviewed
reputable
databases,
including
PubMed,
EMBASE,
COCHRANE,
seeking
trials
that
utilized
against
conditions.
A
few
investigated
humans,
after
screening,
13
were
ultimately
included
following
PRISMA
guidelines.
compounds
include
polyphenols
(flavonoids
luteolin
quercetin,
phenolic
acids
rosmarinic
acid,
ferulic
caffeic
other
like
resveratrol),
alkaloids
(such
berberine,
huperzine
A,
caffeine),
terpenoids
ginkgolides
limonene).
The
gathered
evidence
underscores
caffeine,
ginkgolides,
primarily
anti-inflammatory,
antioxidant,
neuroprotective,
counteracting
neuroinflammation,
oxidation,
synaptic
dysfunctions,
which
crucial
aspects
intervention
various
conditions,
Alzheimer's
dementias,
depression,
neuropsychiatric
disorders.
summary,
they
show
use
improvements
cognition,
memory,
disinhibition,
irritability/lability,
aberrant
behavior,
hallucinations,
mood
Cells,
Journal Year:
2024,
Volume and Issue:
13(13), P. 1098 - 1098
Published: June 25, 2024
Migraine
is
a
debilitating
neurological
disorder
characterized
by
recurring
episodes
of
throbbing
headaches
that
are
frequently
accompanied
sensory
disturbances,
nausea,
and
sensitivity
to
light
sound
[...]
Journal of Neural Transmission,
Journal Year:
2024,
Volume and Issue:
131(12), P. 1367 - 1387
Published: Aug. 7, 2024
Millions
of
individuals
around
the
world
are
afflicted
with
Parkinson's
disease
(PD),
a
prevalent
and
incapacitating
neurodegenerative
disorder.
Dr.
Reichmann,
distinguished
professor
neurologist,
has
made
substantial
advancements
in
domain
PD
research,
encompassing
both
fundamental
scientific
investigations
practical
applications.
His
research
illuminated
etiology
treatment
PD,
as
well
function
energy
metabolism
premotor
symptoms.
As
precursor
to
number
neurotransmitters
neuromodulators
that
implicated
pathophysiology
he
also
investigated
application
tryptophan
(Trp)
derivatives
disease.
principal
findings
insights
summarized
synthesized
this
narrative
review
article,
which
emphasizes
challenges
implications
for
future
research.
This
aims
identify
analyze
key
contributions
Reichmann
field
ultimate
goal
informing
directions
domain.
By
examining
Reichmann's
work,
study
seeks
provide
comprehensive
understanding
his
major
how
they
can
be
applied
advance
diagnosis
PD.
paper
explores
potential
intersection
emerging
avenues,
such
investigation
Trp
its
metabolites,
particularly
kynurenines,
could
lead
new
therapeutic
strategies
managing
disorders
like
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(10), P. 1354 - 1354
Published: Oct. 10, 2024
Metabolic-Associated
Fatty
Liver
Disease
(MAFLD)
is
a
clinical-pathological
scenario
that
occurs
due
to
the
accumulation
of
triglycerides
in
hepatocytes
which
considered
significant
cause
liver
conditions
and
contributes
an
increased
risk
death
worldwide.
Even
though
possible
causes
MAFLD
can
involve
interaction
genetics,
hormones,
nutrition,
lifestyle
(diet
sedentary
lifestyle)
most
influential
factor
developing
this
condition.
Polyphenols
comprise
many
natural
chemical
compounds
be
helpful
managing
metabolic
diseases.
Therefore,
aim
review
was
investigate
impact
oxidative
stress,
inflammation,
mitochondrial
dysfunction,
role
polyphenols
MAFLD.
Some
reverse
part
damage
related
or
among
them
are
anthocyanin,
baicalin,
catechin,
curcumin,
chlorogenic
acid,
didymin,
epigallocatechin-3-gallate,
luteolin,
mangiferin,
puerarin,
punicalagin,
resveratrol,
silymarin.
These
have
actions
reducing
plasma
enzymes,
body
mass
index,
waist
circumference,
adipose
visceral
indices,
lipids,
glycated
hemoglobin,
insulin
resistance,
HOMA
index.
They
also
reduce
nuclear
factor-KB
(NF-KB),
interleukin
(IL)-1β,
IL-6,
tumor
necrosis
factor-α
(TNF-α),
blood
pressure,
fat
content,
steatosis
fibrosis.
On
other
hand,
they
improve
HDL-c,
adiponectin
levels,
fibrogenesis
markers.
results
show
promising
prevention
treatment
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2096 - 2096
Published: Sept. 13, 2024
The
triad
of
vascular
impairment,
muscle
atrophy,
and
cognitive
decline
represents
critical
age-related
conditions
that
significantly
impact
health.
Vascular
impairment
disrupts
blood
flow,
precipitating
the
mass
reduction
seen
in
sarcopenia
neuronal
function
characteristic
neurodegeneration.
Our
limited
understanding
intricate
relationships
within
this
hinders
accurate
diagnosis
effective
treatment
strategies.
This
review
analyzes
interrelated
mechanisms
contribute
to
these
conditions,
with
a
specific
focus
on
oxidative
stress,
chronic
inflammation,
impaired
nutrient
delivery.
aim
is
understand
common
pathways
involved
suggest
comprehensive
therapeutic
approaches.
dysfunctions
hinder
circulation
transportation
nutrients,
resulting
characterized
by
atrophy
weakness.
dysfunction
have
negative
physical
quality
life.
Neurodegenerative
diseases
exhibit
comparable
pathophysiological
affect
motor
functions.
Preventive
approaches
encompass
lifestyle
adjustments,
addressing
integrated
therapies
improving
muscular
well-being.
Better
links
can
refine
strategies
yield
better
patient
outcomes.
study
emphasizes
complex
interplay
between
dysfunction,
degeneration,
decline,
highlighting
necessity
for
multidisciplinary
Advances
domain
promise
improved
diagnostic
accuracy,
more
options,
enhanced
preventive
measures,
all
contributing
higher
life
elderly
population.
