AJP Gastrointestinal and Liver Physiology, Journal Year: 2024, Volume and Issue: 327(2), P. G120 - G122
Published: Aug. 1, 2024
Language: Английский
Journal of Pharmaceutical Analysis, Journal Year: 2023, Volume and Issue: 13(12), P. 1408 - 1428
Published: Sept. 22, 2023
This review aims to identify in vivo studies investigating the potential of plant substances and their natural molecules managing inflammatory bowel disease (IBD). Specifically, objective is examine impact these on interleukins other key signaling markers. Relevant articles published up December 2022 were identified through a search PubMed, Scopus, Web Science, Embase databases. The used keywords including "inflammatory disease", "medicinal plants", "natural molecules", "anti-inflammatory", "ulcerative colitis", 1,878 potentially relevant articles, which 89 included this after completion selection process. study provides preclinical data products (NPs) that can treat IBD, ulcerative colitis. main actions NPs relate effects nuclear factor kappa B (NF-κB), Janus kinase (JAK)/signal transducer activator transcription (STAT) pathway, regulation T helper 17/regulatory cells balance, oxidative stress. ability inhibit intestinal inflammation appears be dependent lowering levels pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-17, via Jun N-terminal (JNK)1, NF-κβ-p65, STAT3 pathways. In addition, shown reduce stress severity colitis, as well increase activity antioxidant enzymes. These suggest represent promising treatment for have greater efficacy safety than current treatments.
Language: Английский
Citations
31
Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 283 - 283
Published: Feb. 22, 2024
Natural products (NPs) have played a vital role in human survival for millennia, particularly their medicinal properties. Many traditional medicine practices continue to utilise crude plants and animal treating various diseases, including inflammation. In contrast, contemporary focuses more on isolating drug-lead compounds from NPs develop new better treatment drugs inflammatory disorders such as bowel diseases. There is an ongoing search drug leads there still no cure many conditions. Various approaches technologies are used discoveries NPs. This review comprehensively anti-inflammatory small molecules describes the key strategies identifying, extracting, fractionating small-molecule leads. also discusses (i) most recently available techniques, artificial intelligence (AI), (ii) machine learning, computational discovery; (iii) provides models cell lines in-vitro in-vivo assessment of potential
Language: Английский
Citations
11
Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(3), P. 1743 - 1757
Published: April 3, 2024
Language: Английский
Citations
10
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633
Published: Dec. 13, 2024
Language: Английский
Citations
10
Foods, Journal Year: 2024, Volume and Issue: 13(4), P. 585 - 585
Published: Feb. 15, 2024
Colitis is a chronic disease associated with alterations in the composition of gut microbiota. Schisandra chinensis bee pollen extract (SCPE) has been proved to be rich phenolic compounds and effective modulating microbiota, but its effect on colitis underlying mechanism remains unclear. This study investigates relationship between amelioration microbiota regulation SCPE via fecal microbial transplantation (FMT). The results showed that administration 20.4 g/kg BW could primely ameliorate induced by dextran sulfate sodium (DSS) mice, showing as more integration colon tissue structure colonic epithelial barrier, well lower oxidative stress inflammation levels compared mice. Moreover, supplement restored balance T regulatory (Treg) cells helper 17 (Th17) cells. Gut analysis treatment reshape improve abundance especially beneficial bacteria (Akkermansia Lactobacillus) related production short-chain fatty acids immunity. Most importantly, protection can perfectly transmitted Therefore, microbiota–SCFAS–Treg/Th17 axis main for colitis. suggests new promising functional food prevention reshaping regulating
Language: Английский
Citations
5
Molecules, Journal Year: 2023, Volume and Issue: 28(19), P. 6811 - 6811
Published: Sept. 26, 2023
Intestinal inflammation is a chronic gastrointestinal disorder with uncertain pathophysiology and causation that has significantly impacted both the physical mental health of people animals. An increasing body research demonstrated critical role cellular signaling pathways in initiating managing intestinal inflammation. This review focuses on interactions three (TLR4/NF-κB, PI3K-AKT, MAPKs) immunity gut microbiota to explain possible pathogenesis Traditional medicinal drugs frequently have drawbacks negative side effects. paper also summarizes pharmacological mechanism application Chinese herbal compounds (Berberine, Sanguinarine, Astragalus polysaccharide, Curcumin, Cannabinoids) formulae (Wumei Wan, Gegen-Qinlian decoction, Banxia xiexin decoction) against We show may influence among cell pathways, immune function, humans animals, exerting their immunomodulatory capacity anti-inflammatory antimicrobial demonstrates strong potential improve aim promote medicine apply it multispecies animals achieve better health.
Language: Английский
Citations
12
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 30, 2024
Ulcerative colitis (UC) is marked by recurring inflammation. Existing treatments are ineffective and may have toxic side effects. Thus, new therapeutic agents urgently needed. We studied the botanical formula "Li-Hong Tang (LHT)", which contains two main ingredients,
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3320 - 3320
Published: April 2, 2025
Inflammatory bowel disease (IBD), including Crohn's (CD) and ulcerative colitis (UC), is a rising global health issue. Chronic intestinal inflammation an important risk factor for colorectal cancer (CRC). Despite significant progress in IBD CRC treatment, numerous patients remain resistant to standard pharmacotherapy or experience severe side effects that prevent them from continuing treatment. There evidence suggesting bioactive substances Lentinula edodes have immunomodulatory anticancer properties. This fungus currently classified as functional food, considering its beneficial on human special nutritional value. Studies conducted vitro animal models demonstrated L. compounds, particular glucans, anti-inflammatory antioxidant effects, induce apoptosis of cells, reduce tumor angiogenesis, restore gut microbiome heterogeneity improve barrier dysfunction. Moreover, clinical trials confirmed these compounds combined with chemotherapy effect improving the prognosis patients. In addition, glucans increase microbial diversity enhance interferon (IFN)-γ production by immune cells. Future studies must be focused understanding pathways mechanisms associated observed effects. both randomized long-term follow-up are needed confirm their effectiveness treatment CRC.
Language: Английский
Citations
0
European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 12, P. 100199 - 100199
Published: Aug. 10, 2024
Calendula, commonly known as marigold, is a plant of the Asteraceae family with rich history medicinal use. This possesses variety bioactive compounds, including steroids, terpenoids, triterpenoids, phenolic acids, flavonoids, carotenoids, and essential oils. These compounds confer significant anti-inflammatory, antioxidant, antimicrobial, anticancer properties to making it promising candidate for treating various skin conditions, particularly wounds. Calendula extracts hold potential applications in pharmaceutical, food, cosmetic industries. Notably, these can be utilized drug delivery systems natural biomaterials, offering benefits health conditions. review aims provide an updated synthesis medical pharmacological uses focus on its role wound healing systems. It addresses limitations using Calendula's active insights future research application.
Language: Английский
Citations
3
Turkish Journal of Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 24, 2025
Abstract Objectives In this study, Rosa damascena Mill. essential oil (RDEO) was aimed to evaluate its potential anti-inflammatory and mitochondria-mediated anti-apoptotic effects in vitro vivo acetic acid (AA)-induced ulcerative colitis (UC) rat model. Methods the UC model, RDEO (100 μL/kg, p.o.) or sulfasalazine mg/kg/p.o.) administered treatment groups. After decapitation, activity index, colon mass macroscopic microscopic damages were determined tissue. TNF-α levels MPO measured effect of inflammation colon. Changes expression ofBcl-2, Bax, casp-3, casp-9 proteins, which are indicators mitochondrial-mediated apoptosis by Western blot method. Results Our study results revealed that AA-induction caused a significant increase index (CAI), (CMI), It shows has an effective curative reducing AA-induced (TNF-α activity), CAI, CMI, pro-apoptotic protein (Bcl-2, Casp-3, Casp-9), morphological Conclusions All these suggest may have suppressed changes tissue due ability reduce apoptosis. The showed beneficial and, like other herbal agents, did not cause gastrointestinal side effects.
Language: Английский
Citations
0