Effect of Nut Consumption on Human Gene Expression: A Systematic Review of Clinical Trials

Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Context The consumption of nuts has beneficial effects on cardiovascular health, body composition, cognitive functions, the intestinal microbiota, and satiety control, but how their nutrients impact related gene expression is unclear. Objective We analyzed nut human as investigated in controlled clinical trials. Data Sources This systematic review was conducted according to PRISMA guidelines. databases used search were MEDLINE/PubMed, Embase, Cochrane Library. Extraction Randomized nonrandomized trials date that evaluated effect mRNA genes eligible criteria. Two authors screened determined quality studies; disagreements resolved by third author between May June 2024. All involved analyzing compiled data. Analysis selected 13 original articles. Most studies Brazil nuts, followed using combinations two or more with an interventional duration six weeks one year. hazelnuts increased antioxidant-related genes, while regulation proinflammatory pathways (tumor necrosis factor - TNF, interleukin-6 IL-6, toll-like receptors 2 4 TLR2 TLR4) reported after nuts. Genes vascular inflammation (eg, ciclooxygenase-2 COX-2) downregulated mixed selenoprotein SELENOP glutathione peroxidase 1 GPX1 regulated presence single nucleotide polymorphisms Finally, pistachio reduced telomere oxidation (telomerase reverse transcriptase TERT WD repeat containing antisense TP53 WRAP53) resistin IL-6 genes. Conclusion modulating progression chronic diseases, emphasis inflammation, oxidative stress, health. Systematic Review Registration PROSPERO registration No. CRD42024505199.

Language: Английский

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The impact of nut consumption on vascular endothelial function: a GRADE-assessed systematic review and meta-analysis of data from randomised controlled trials

International Journal of Food Sciences and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: May 6, 2025

This meta-analysis aimed to evaluate the effect of nut consumption on vascular endothelial function through conduction a comprehensive review randomised controlled trials. We explored major electronic databases for published RCTs examining repercussions nuts indicators in adults (>18 years). used random-effects models compute pooled estimates weighted mean differences and confidence intervals. The protocol present study was registered international database systematic protocols (CRD42023472892). Nineteen articles, comprising 21 arms, were deemed eligible. According estimations, eating significantly improved flow-mediated dilation (FMD) (weighted difference (WMD): 1.12%, 95% CI 0.28 1.97, p < 0.05), reactive hyperaemia index (RHI) (WMD: -0.04, -0.07 -0.00, = 0.04). However, findings revealed that consuming had no significant impact pulse wave velocity (PWV), augmentation (AIx), or heart rate. considerably enhanced by improvement FMD, while certainty such evidence assessed as very low.

Language: Английский

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The Key Nutrients in the Mediterranean Diet and Their Effects in Inflammatory Bowel Disease: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4201 - 4201

Published: Dec. 5, 2024

The gut microbiome, a collection of microorganisms, is crucial in the development and progression inflammatory bowel diseases (IBD). Therefore, diet dietary interventions are promising strategies to shape microbiota for IBD management. Of all diets studied field, Mediterranean has least restrictive nature, promoting long-term adherence. rich plants, with high daily intake fruits vegetables (high fiber, antioxidants, vitamins), olive oil, whole grains, legumes, nuts. It includes moderate consumption animal products such as oily fish (rich mono- polyunsaturated fatty acids), dairy products, poultry, limited red meat processed foods. This associated decreased risk chronic diseases, including IBD. However, mechanisms specific nutrients behind these effects remain under investigation. this review, we aim provide an overview that abundant their on IBD, main focus preclinical evidence. While several like fructo-oligosaccharide, chitosan, plant-derived protein, polyphenols, omega-3 acids, resveratrol have shown potential beneficial models, clinical evidence often limited. understanding complex interactions between essential developing tailored, multidisciplinary, personalized approach disease management; therefore, further research required.

Language: Английский

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miR482f and miR482c-5p from edible plant-derived foods inhibit the expression of pro-inflammatory genes in human THP-1 macrophages

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Nov. 30, 2023

Edible plants can exert anti-inflammatory activities in humans, being potentially useful the treatment of inflammatory diseases. Plant-derived microRNAs have emerged as cross-kingdom gene expression regulators and could act bioactive molecules involved beneficial effects some edible plants. We investigated role plant-derived modulation pro-inflammatory human genes. MicroRNAs from foods were identified by next-generation sequencing. with putative targets selected, after performing silico analyses. The candidate miRNAs was analyzed qPCR their evaluated THP-1 monocytes differentiated to macrophages. bioavailability plant humans feces serum samples qPCR. miR482f miR482c-5p are present several foods, such fruits, vegetables, cooked legumes cereals, fats oils. Transfections mimics decreased CLEC7A NFAM1, TRL6, respectively, macrophages, which had an impact on profile biomarkers. Both (miR482f miR482c-5p) resisted degradation during digestion detected feces, although not serum. Our findings suggest that promote macrophages vitro be achieved through diet, but eventually restricted at gut level.

Language: Английский

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Significant Increase in Oxidative Stress Indices in Erythrocyte Membranes of Obese Patients with Metabolically-Associated Fatty Liver Disease

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(3), P. 315 - 315

Published: March 18, 2024

Metabolic dysfunction-associated hepatic steatosis (MAFLD) indicates the metabolic risk associated with steatosis, overweight and obesity, clinical evidence of dysregulation. Since MAFLD is one diseases that show a high frequency alterations in lipid content cell membranes, aim this study was to evaluate indices oxidative damage erythrocyte membranes obese subjects. The conducted on serum samples red blood For each patient, biochemical measurements lipidomic analyses erythrocytes were performed. Significant differences fatty acid profiles RBC found between patients. In particular, Peroxidation Index (PI) higher subjects than same behavior observed for Unsaturation (UI) Free Radical Stress (Free RSI), supporting fact systemic increase stress obesity. shows there different susceptibility membrane peroxidation subjects, increased values patients may be possible indicator pro-oxidative events occurring obesity-related diseases.

Language: Английский

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The Portfolio Diet and HbA1c in Adults Living with Type 2 Diabetes Mellitus: A Patient-Level Pooled Analysis of Two Randomized Dietary Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2817 - 2817

Published: Aug. 23, 2024

The Portfolio Diet, a dietary pattern of cholesterol-lowering foods, is also rich in low glycemic index (GI) foods. While strong evidence supports clinically meaningful reductions cholesterol, on the relationship between Diet and diabetes management lacking.

Language: Английский

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An Overview of the Characteristics, Advantages, and Uses of Nuts

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Nuts possess a high concentration of essential nutrients and serve as very effective source bioactive chemicals that promote health. Therefore, they function significant nutritious snacks, while also being incorporated into numerous conventional contemporary culinary preparations over the globe. It is strongly advised to regularly consume nuts in order fully capitalize on nutritional, bioactive, antioxidant properties possess, well experience their desired taste flavor. Robust scientific data indicate individuals who consistently quantities (15 30 g nuts) exhibit reduced prevalence chronic non-communicable diseases. have been found positive health impacts, such potential manage obesity decrease occurrence cardiovascular disease (CVD), type 2 diabetes, several types cancer, other diseases associated with food. The most robust persistent impact nut consumption its correlation decreased incidence (CVD). find application food products within industry, encompassing oil, spreads, sectors cosmetics medicine, viable biodiesel. objective this chapter provide comprehensive overview characteristics, advantages, uses nuts.

Language: Английский

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Effect of Nuts Combined with Energy Restriction on the Obesity Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Foods, Journal Year: 2024, Volume and Issue: 13(18), P. 3008 - 3008

Published: Sept. 23, 2024

Obesity is a multifactorial disease that difficult to control worldwide. Although nuts are recognized health foods, the application of food in obesity management unclear. We systematically reviewed literature and performed meta-analysis evaluate if nut consumption favors people on energy restriction (ER) dietary interventions. Four databases were used search for eligible articles May 2024. This review was conducted according PRISMA guide, bias risk papers evaluated. For meta-analysis, we extracted endpoint values group's variables estimated effect sizes by random-effects model. Sixteen ten included systematic respectively. Almonds evaluated majority studies (

Language: Английский

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Association of oxidative balance score with blood pressure, all-cause and cardiovascular disease mortality among hypertensive patients: a prospective study

Journal of Hypertension, Journal Year: 2024, Volume and Issue: 43(3), P. 492 - 503

Published: Nov. 20, 2024

The oxidative balance score (OBS) has emerged as a novel marker for assessing stress status. This study aimed to investigate the association of OBS with systolic blood pressure (SBP), diastolic (DBP), all-cause, and cardiovascular disease mortality in hypertensive patients. We conducted an analysis data from 7602 patients National Health Nutrition Examination Survey (NHANES) 2005-2018. Multiple linear regression, Cox proportional hazards models, Kaplan-Meier survival curves, restricted cubic spline, subgroup were used examine between SBP, DBP, estimated pulse wave velocity (ePWV), risk. results showed that individuals highest quartile (27 ≤ 40) had significant 2.41 mmHg reduction SBP compared lowest (5 15) ( Ptrend < 0.001). Compared quartile, 29% lower risk all-cause 44% inverse persisted irrespective antihypertensive medication use. is inversely associated finding provides new evidence suggestions those poor control low (<15) adjust their diet lifestyle reasonably.

Language: Английский

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The Pharmacological Potential of Resveratrol in Reducing Soft Tissue Damage in Osteoarthritis Patients

Current Rheumatology Reviews, Journal Year: 2023, Volume and Issue: 20(1), P. 27 - 38

Published: Sept. 11, 2023

Osteoarthritis is a degenerative joint disease that causes the cartilage and bone underneath to break down. This pain stiffness. Resveratrol, polyphenolic compound found in various vegetables, fruits, red wine, has been studied for its beneficial effects on osteoarthritis. Resveratrol shown target variety of pathways, including NF-κB, PI3K/Akt, MAPK/ERK, AMPK pathways. In particular, resveratrol potential use treating osteoarthritis, it reduce inflammation, degradation, improve function. this review, we discuss evidence pharmacological minimizing soft tissue damage associated with We summarize studies how anti-inflammatory, anti-oxidant, anti-apoptotic effects, as well osteoblast synoviocyte proliferation, cytokine production. also possible mechanisms action osteoarthritis therapeutic agent. Finally, risks adverse long-term supplementation. Overall, be treatment because properties, ability control production enzymes down cartilage, osteoblasts, synoviocytes. Although numerous clinical have demonstrated resveratrol's efficacy an management agent, further are needed better understand safety benefits using management.

Language: Английский

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