Effect of a 12-Week Walking Program Monitored by Global Physical Capacity Score (GPCS) on Circulating Cell-Free mtDNA and DNase Activity in Patients with Irritable Bowel Syndrome

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4293 - 4293

Published: April 12, 2024

Irritable bowel syndrome (IBS) involves low-grade mucosal inflammation. Among the various approaches capable of managing symptoms, physical activity is still under investigation. Despite its benefits, it promotes oxidative stress and Mitochondria impacts gut disorders by releasing damage-associated molecular patterns, such as cell-free mtDNA (cf-mtDNA), which support This study evaluated effects a 12-week walking program on cf-mtDNA DNase in 26 IBS 17 non-IBS subjects. Pro- anti-inflammatory cytokines were ELISA. Digital droplet PCR was used to quantify cf-mtDNA; assessed using single radial enzyme diffusion assay. PCR-RFLP genotype DNASE1 rs1053874 SNP. Significantly lower IL-10 levels found than individuals. Exercise reduced subjects but not patients. did correlate with patients post-exercise, indicating imbalanced clearance. Different SNP frequencies between groups. The confirms positive regular moderate-intensity healthy role release Walking alone might sufficiently reduce subclinical inflammation IBS, based pro- molecules. Prolonged programs are necessary investigate their inflammatory markers IBS.

Language: Английский

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The Role of Diet in the Management of Irritable Bowel Syndrome: A Comprehensive Review

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 15, 2024

Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder that has significant impact on the general population. The suboptimal medical treatments available for IBS contribute to its large economic burden. pathophysiology of complex, and often focus managing specific symptoms. Many individuals with associate their symptoms food intake, leading increased scientific research role diet in IBS. Dietary management become crucial aspect treatment, initial recommendations focusing adopting healthy eating pattern lifestyle. This comprehensive review aims synthesise current literature IBS, exploring various dietary approaches including low fermentable oligosaccharides, disaccharides, monosaccharides, polyols (FODMAP) diet, gluten-free Mediterranean tritordeum-based diet. It presents evidence from both experimental observational studies summarises underlying triggers gut microbiota dysbiosis, visceral hypersensitivity, immune activation. In addition, it explores efficacy limitations key lifestyle provided by guidelines literature, highlighting importance individualised strategies tailored unique needs different types patients. By elucidating complex interplay between pathophysiology, this provides valuable insights into optimising improving symptom control enhancing quality life

Language: Английский

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Relationship Between FODMAP Diet and Irritable Bowel Syndrome: A Mendelian Randomization Study

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(2)

Published: Feb. 1, 2025

ABSTRACT There is some evidence of a link between fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet irritable bowel syndrome (IBS). However, few studies have analyzed the relationship specific dietary intakes IBS using Mendelian randomization (MR). Exposure outcome datasets were sourced from IEU Open GWAS project. Genetic variants significantly associated with 28 at genome‐wide level selected as instrumental variables. Summary statistics for target obtained sample 187,028 European individuals (4605 cases, 182,423 controls). Univariable multivariable MR analyses conducted to estimate overall independent associations after adjustment genetic liability intestinal flora. predispositions six decreased risk IBS, including dried fruit, beef, cereal, lobster/crab, feta, coffee, while cherry poultry intake an increased IBS. Three eight persisted adjusting genetically predicted flora, analysis identified that salad/raw vegetable was Twenty did not remain This study provides supporting causal FODMAP

Language: Английский

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The Impact of a Twelve-Week Moderate Aerobic Exercise Program on Gastrointestinal Symptom Profile and Psychological Well-Being of Irritable Bowel Syndrome Patients: Preliminary Data from a Southern Italy Cohort

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(16), P. 5359 - 5359

Published: Aug. 17, 2023

Walking is popular moderate-intensity aerobic exercise that improves mental and gastrointestinal (GI) health. It can relieve symptoms associated with irritable bowel syndrome (IBS), e.g., intestinal gas, abdominal distension, disturbances. This study examined the impact of a program on clinical psychological parameters IBS patients. In total, 40 patients (11 males 29 females; mean age 51.9 ± 7.8 years) participated in 12-week program. Participants completed questionnaires assessing GI symptoms, profiles, quality life (QoL) before after intervention. Field tests, anthropometric measurements, bioimpedance assessments were also conducted. The present findings confirmed significant improvement Bloating was most common symptom and, together pain, significantly reduced treatment. Psychological QoL indicated decreased anxiety, depression, somatization, stress levels. Correlations found between anxiety/depression severity pain as well distension. Moderate-intensity positively impacted well-being, complementing dietary support non-pharmacological therapy for management IBS. These emphasize importance alternative approaches

Language: Английский

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Functional Foods and Nutraceuticals in Irritable Bowel Syndrome

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1830 - 1830

Published: March 8, 2025

Irritable bowel syndrome (IBS) is a common disorder of gut–brain interaction, with multifactorial pathophysiology involving axis dysregulation, visceral hypersensitivity, microbiota imbalance, and immune dysfunction. Traditional IBS management emphasizes dietary modifications pharmacologic therapies. However, increasing attention has been directed toward functional foods, nutraceuticals, herbal remedies due to their potential target pathophysiological mechanisms favorable safety profiles. This clinical review explores the role these adjunctive therapies, evaluating evidence from preclinical studies. Functional foods such as kiwifruit, prunes, rye bread demonstrate benefits in habit regulation through fiber content modulation. Nutraceuticals like peppermint oil, palmitoylethanolamide, mixtures exhibit anti-inflammatory, antispasmodic, analgesic effects. Prebiotics provide substrate-driven changes, although dosage key, given fermentative properties, when used at high dosages, they can exacerbate symptoms some individuals. Probiotics postbiotics offer microbiota-based interventions promising symptom relief subtypes, factors for personalized treatment still need be further elucidated. These strategies highlight paradigm shift management, integrating diet-based therapies evolving nutraceutical options improve patient outcomes. Despite findings, challenges standardizing definitions, mechanisms, profiles remain. Rigorous, large-scale trials validate therapeutic are needed, enhance compounds an individualized approach.

Language: Английский

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The Effect of Polyphenols, Minerals, Fibers, and Fruits on Irritable Bowel Syndrome: A Systematic Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 4070 - 4070

Published: Sept. 20, 2023

Background: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain, bloating, and changes in habits. Various dietary factors have been implicated the pathogenesis management of IBS symptoms. This systematic review aims to evaluate effects polyphenols, minerals, fibers, fruits on symptoms overall well-being individuals with IBS. Materials Methods: A comprehensive literature search was conducted several electronic databases, including PubMed, Scopus, Web Science. Studies published up until July 2023 were included. Results: The selected studies varied terms study design, participant characteristics, intervention duration, outcome measures. Overall, findings suggest that interventions involving can positive impact Dietary fiber supplementation, particularly soluble fiber, has associated reduced bloating enhanced stool consistency. Conclusions: provides evidence supporting beneficial patients. These components hold promise as complementary approaches for managing However, due heterogeneity included limited number high-quality randomized controlled trials, further well-designed trials are warranted establish optimal dosages, long-term these interventions. Understanding role specific may pave way personalized recommendations improve quality life suffering from this complex disorder.

Language: Английский

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Enhanced Physical Capacity and Gastrointestinal Symptom Improvement in Southern Italian IBS Patients following Three Months of Moderate Aerobic Exercise

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(21), P. 6786 - 6786

Published: Oct. 26, 2023

Moderate-intensity aerobic exercise improves gastrointestinal (GI) health and alleviates irritable bowel syndrome (IBS) symptoms. This study explored its effects on physical capacity (PC) IBS symptoms in 40 patients from Southern Italy (11 males, 29 females; 52.10 ± 7.72 years). The program involved moderate-intensity (60/75% of HRmax) for at least 180 min per week. Before after the intervention, participants completed IBS-SSS questionnaire to assess symptoms, reported their activity levels, underwent field tests evaluate PC. PC was quantified as Global Physical Capacity Score (GPCS). A total 38 subjects (21 17 53.71 7.27 years) without lower GI served a No group. significant differences were found between subjects, except symptom score, expected. After exercise, all experienced improvements both Higher levels correlated with greater benefits symptomatology, especially GPCS reaching above-average values. Engaging week positively impacts Monitoring provides insights into connection severity, aiding healthcare professionals tailoring effective treatment plans.

Language: Английский

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Tritordeum: Promising Cultivars to Improve Health

Foods, Journal Year: 2024, Volume and Issue: 13(5), P. 661 - 661

Published: Feb. 22, 2024

Tritordeum is an amphiploides species resulting from the hybridization between durum wheat (T. durum) and wild barley (H. chilense). This new cereal considered a natural crop as it obtained by traditional breeding techniques. Given its appreciable organoleptic characteristics, agronomic features, presence of interesting components, good technological properties, promising interest for development health-oriented foods. In this study, we evaluated two registered cultivars, Bulel Aucan. T. (Provenzal) was employed positive control. The extracted proteins were digested gastric/pancreatic proteases, their biological effects on Caco-2 differentiated transwell inserts determined. Changes in cell viability, monolayer permeability, organization F-actin microfilaments, ER stress triggered protein-digested samples (DPs) inspected. Our results showed that exposure to Provenzal-DPs promptly disrupted tight junction barrier. Conversely, Aucan-DPs did not enhance whereas Bulel-DPs exerted only slight effects. Provental-DPs-induced toxicity also confirmed changes viability deep reorganization enterocyte cytoskeleton. contrast, affect cytoskeleton structure. Overall, our findings suggest both cultivars could be potential candidates mitigating flour.

Language: Английский

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StepFit-18K: Improving Irritable Bowel Syndrome (IBS) Symptoms with a Simple, Structured Walking Intervention

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(22), P. 6684 - 6684

Published: Nov. 7, 2024

Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal (GI) disorder characterized by abdominal pain, altered bowel habits, and bloating, affecting approximately 10.1% of the global population. While current treatments emphasize dietary modifications symptom management, emerging evidence suggests that physical activity (PA) may help alleviate IBS symptoms. This study evaluated effects structured walking program, "StepFit-18K", on relief.

Language: Английский

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Current state of the non‐pharmacological management of irritable bowel syndrome: an up‐to‐date review of the literature

Internal Medicine Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Irritable bowel syndrome (IBS) is a complex disorder of gut–brain interaction (DGBI) that thought to affect significant proportion the population. As result nature IBS, it hard predict treatment efficacy as all individuals respond differently, and thus multidisciplinary has become increasingly interest targets multiple aspects IBS at same time. Here, we aim review literature both single‐discipline therapy for IBS. Ovid MEDLINE was utilised with systematic search find relevant randomised controlled trials. The population included adults Rome diagnosis an intervention either care, diet, psychotherapy, gut‐directed hypnotherapy (GDH) or physiotherapy. Multidisciplinary care studies found overall improvement, while dietary varied. A low fermentable oligosaccharides, disaccharides, monosaccharides polyols diet only one improve symptoms, gluten‐free fibre diets had mixed evidence their efficacy. Novel diets, including tritordeum‐based tryptophan significantly improved symptoms. Cognitive behavioural be efficacious when compared controls, psychoeducation. GDH also efficacious, but 83.3% examined refractory There lack looking how different combinations disciplines work treat those in secondary care. Further are required greater understanding may better manage

Language: Английский

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