A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder DOI Creative Commons
Adriano Alberti, Willians Fernando Vieira, David Richer Araujo Coelho

et al.

Photonics, Journal Year: 2024, Volume and Issue: 11(9), P. 839 - 839

Published: Sept. 5, 2024

Major depressive disorder (MDD) is a prevalent mental health condition affecting significant portion of the population worldwide. This can impact individuals all ages, including adolescents, leading to an on various aspects their lives. Adolescence crucial phase human development, characterized by several neurobiological changes. The onset MDD during this period result in damage not only teenagers but also might have long-lasting implications for future as adults. Notably, adolescents often associated with biomarkers, such increased levels inflammatory cytokines (e.g., IL-6, TNF-α), oxidative stress markers, and alterations neurotransmitter levels, indicating complex interplay biological factors. Therefore, early intervention essential addressing phase. Photobiomodulation therapy (PBMT) emerges innovative promising approach that utilizes light, especially near-infrared (NIR) red spectra, trigger therapeutic effects. targeting skull abdomen PBMT explore bidirectional communication between intestinal system central nervous remote and/or systemic way. In context, we present rationale design ongoing study aiming assess efficacy symptoms biomarkers mitochondrial function MDD.

Language: Английский

Blue Light and Temperature Actigraphy Measures Predicting Metabolic Health Are Linked to Melatonin Receptor Polymorphism DOI Creative Commons
Denis Gubin, Konstantin V. Danilenko, Oliver Stefani

et al.

Biology, Journal Year: 2023, Volume and Issue: 13(1), P. 22 - 22

Published: Dec. 30, 2023

This study explores the relationship between light features of Arctic spring equinox and circadian rhythms, sleep metabolic health. Residents (N = 62) provided week-long actigraphy measures, including exposure, which were related to body mass index (BMI), leptin cortisol. Lower wrist temperature (wT) higher evening blue exposure (BLE), expressed as a novel index, nocturnal excess (NEIbl), most sensitive measures associated with BMI. A BMI was linked BLE within distinct time windows. These associations present specifically in carriers MTNR1B rs10830963 G-allele. larger wake-after-sleep onset (WASO), smaller 24 h amplitude earlier phase activity rhythm leptin. Higher cortisol an M10 our other Daylight Deficit Index light, DDIbl. We also found sex-, age- population-dependent differences parametric non-parametric indices BLE, wT physical activity, while there no any characteristics. Overall, this determined markers predictive health showed that these are melatonin receptor polymorphism.

Language: Английский

Citations

19

Τhe effect of artificial lighting on both biophilic and human-centric design DOI
Evangelos-Nikolaos D. Madias, Konstantinos Christodoulou, Vasilios P. Androvitsaneas

et al.

Journal of Building Engineering, Journal Year: 2023, Volume and Issue: 76, P. 107292 - 107292

Published: July 8, 2023

Language: Английский

Citations

16

The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis DOI Open Access
Balázs Csoma, András Bikov

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14145 - 14145

Published: Sept. 15, 2023

Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Many lines evidence suggest that disturbances in circadian rhythm responsible for development CVDs; however, misalignment is not yet a treatable trait clinical practice. The controlled by central clock located suprachiasmatic nucleus and genes (molecular clock) all cells. Dyslipidaemia vascular inflammation two hallmarks atherosclerosis numerous experimental studies conclude they under direct influence both molecular clocks. This review will summarise results on lipid metabolism, rhythm, translate them into pathophysiology cardiovascular disease. We discuss effect time-respected administration medications medicine. bright light melatonin health, metabolism inflammation. Finally, we an agenda future research recommend

Language: Английский

Citations

14

Light Environment of Arctic Solstices is Coupled With Melatonin Phase‐Amplitude Changes and Decline of Metabolic Health DOI Open Access
Denis Gubin, Konstantin V. Danilenko, Oliver Stefani

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 77(1)

Published: Dec. 26, 2024

Light environment in the Arctic differs widely with seasons. Studies of relationships between objectively measured circadian phase and amplitude light exposure melatonin community-dwelling residents are lacking. This investigation combines cross-sectional (n = 24-62) longitudinal 13-27) data from week-long actigraphy (with sensor), 24-h salivary profiles, proxies metabolic health. Data were collected within same week bracketing spring equinox (SE), winter/summer solstices (WS/SS). Drastic seasonal differences blue (BLE) corresponded to changes pattern melatonin, which was delayed reduced normalized (NA) during WS/SS compared SE. The extent individual melatonin's acrophase Dim Melatonin Onset (DLMO) change SE WS correlated that SS. Although similar direction, versus linked morning BLE deficit WS, contrasting evening excess Seasonal sleep characteristics closely associated phases melatonin. Proxies health included triglycerides (TG), high-density lipoprotein cholesterol (HDL), TG/HDL ratio, cortisol. Adverse these acrophases TG higher SS than SE, cross-sectionally later acrophases, while lower HDL onset acrophase. Overall, this study shows optimal patterns is an earlier a larger both features better Improving hygiene, particular correcting winter summer may help maintain at high latitudes. Novel solutions for introducing proper hygiene such as human-centric technologies should be investigated address issues future studies.

Language: Английский

Citations

5

Transcriptomic dysregulation in zebrafish brain exposed to artificial light at night: a comprehensive analysis of gene expression and pathway alterations DOI
Rajendra Kumar Labala, Zeeshan Ahmad Khan, Gopinath Mondal

et al.

Biological Rhythm Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20

Published: Feb. 13, 2025

Language: Английский

Citations

0

Understanding complexity of the migratory phenotype in Palearctic–Indian migratory buntings: connecting molecular dots from laboratory studies DOI Creative Commons
Vinod Kumar, Aakansha Sharma, Vatsala Tripathi

et al.

Journal of Avian Biology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Avian migration has been studied for a long time. Yet, very little is understood about the mechanisms underlying preparation and departure of these migrants twice‐a‐year towards their destination. In recent years, some experimental evidence accumulated from studies on Palearctic‐Indian migratory blackheaded buntings Emberiza melanocephala redheaded bruniceps . These are obligate latitudinal migrant passerines, with yearly to‐and‐fro migrations between breeding grounds in west Asia/southeast Europe overwintering areas India. The voyages not isolated seasonal events; rather, they part overall annual itinerary closely coupled to reproduction. This review focuses mainly that have carried out more than four decades two buntings. We will outline first characteristic traits anticipation, preparation, beginning maintaining flight. subsequent sections summarize briefly molecular fat fuel accumulation, changes associated phasing activity rest periods within 24‐h day during nocturnal flight daytime stopovers. addition, we discuss mechanistic differences onward (to wintering areas, autumn migration) return grounds, spring migrations. differ context, physiological states birds prior each migration, surrounding physical environment (photoperiod, temperature, food availability) encounter period. final section perspectives presents an ecological societal relevance avian research.

Language: Английский

Citations

0

The impact of environmental pollution on metabolic health and the risk of non-communicable chronic metabolic diseases in humans DOI Creative Commons
Caterina Formichi, Sonia Caprio, Laura Nigi

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 103975 - 103975

Published: March 1, 2025

Language: Английский

Citations

0

Exposure to artificial lighting at night: from an ecological challenge to a risk factor for glucose dysmetabolism and gestational diabetes? Narrative review DOI Creative Commons
Lina Zabulienė, Charalampos Milionis,

Eftychia Koukkou

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: March 11, 2025

Artificial lighting at night (ALAN) leads to pervasive light pollution, affecting ecosystems and human health globally. Satellite assessments reveal widespread nocturnal illumination worldwide research indicates adverse effects. Environmental pollution disrupts natural cycles, the behavior reproduction of various organisms. In this narrative review we aimed present on effects ALAN glucose metabolism diabetes hone its recently reported association with gestational (GDM). Conflicting data exist melatonin's administration vis-à-vis glycemia, some studies suggesting beneficial outcomes for patients type 2 mellitus insomnia. Ambient influences plasma glucose, bright increasing both fasting postprandial levels. Perinatal exposure is linked later-life risks prenatal fetal macrosomia. Analyzing European in conjunction epidemiological records GDM reveals a notable probable association. Additionally, recent from China (one case-control two cohort studies) has shown that during pregnancy significantly increases risk GDM. Despite progress, interdisciplinary needed understand impact health, especially regarding disrupted light-dark cycles physiological functions relevant conditions like At present, simplest advice all people particularly women who anticipate pregnancy, or pregnant women, ensure totally dark environment sleep time.

Language: Английский

Citations

0

The Association Between Midpregnancy Food Intake Timing Patterns and Gestational Weight Gain DOI
Marquis Hawkins, Daisy Duan, Namhyun Kim

et al.

Journal of Women s Health, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Background: This article aims to characterize midpregnancy food timing profiles and examine their association with gestational weight gain (GWG). Materials Methods: secondary data analysis of a randomized controlled trial two diabetes screening approaches included 641 individuals primary exposures outcomes data. Food indicators (i.e., first last eating episode time, caloric midpoint the total window) were assessed using 24-hour dietary recalls conducted in midpregnancy. Latent profile was used identify distinct based on these indicators. Regression analyses explored associations between individual intake indicators, profiles, GWG. Results: We identified four profiles: extended window (n = 133; earliest longest window), restricted 120; latest shortest early 188; midpoint), typical 200; aligning sample median). Participants (vs. profile) had an increased risk insufficient GWG (unadjusted relative [RR] 1.85, 95% confidence interval [CI] 1.12, 3.05). Each hour increase associated 0.39 kg (0.03, 0.75) higher Both attenuated adjusted models no longer statistically significant models. Conclusions: but not independently These findings suggest that may play major role

Language: Английский

Citations

0

Effects of 40 Hz Light Flicker Stimulation on Hippocamp-Prefrontal Neural Activity Characteristics During Working Memory Tasks in AD Model Rats DOI
Suhong Liu,

Longlong Wang,

Shuangyan Li

et al.

Lecture notes in electrical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 58 - 68

Published: Jan. 1, 2025

Language: Английский

Citations

0