A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder DOI Creative Commons
Adriano Alberti, Willians Fernando Vieira, David Richer Araujo Coelho

et al.

Photonics, Journal Year: 2024, Volume and Issue: 11(9), P. 839 - 839

Published: Sept. 5, 2024

Major depressive disorder (MDD) is a prevalent mental health condition affecting significant portion of the population worldwide. This can impact individuals all ages, including adolescents, leading to an on various aspects their lives. Adolescence crucial phase human development, characterized by several neurobiological changes. The onset MDD during this period result in damage not only teenagers but also might have long-lasting implications for future as adults. Notably, adolescents often associated with biomarkers, such increased levels inflammatory cytokines (e.g., IL-6, TNF-α), oxidative stress markers, and alterations neurotransmitter levels, indicating complex interplay biological factors. Therefore, early intervention essential addressing phase. Photobiomodulation therapy (PBMT) emerges innovative promising approach that utilizes light, especially near-infrared (NIR) red spectra, trigger therapeutic effects. targeting skull abdomen PBMT explore bidirectional communication between intestinal system central nervous remote and/or systemic way. In context, we present rationale design ongoing study aiming assess efficacy symptoms biomarkers mitochondrial function MDD.

Language: Английский

Cardiometabolic-Based Chronic Disease DOI Creative Commons

Joel Hernández-Sevillano,

Masih A. Babagoli,

Pranav Mellacheruvu

et al.

Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 103 - 132

Published: Jan. 1, 2025

Language: Английский

Citations

0
Wearable Light Loggers in Field Conditions: Corneal Light Characteristics, User Compliance, and Acceptance DOI Creative Commons
Oliver Stefani,

Reto Marek,

Jürg Schwarz

et al.

Clocks & Sleep, Journal Year: 2024, Volume and Issue: 6(4), P. 619 - 634

Published: Oct. 25, 2024

Understanding user challenges with light dosimeters is crucial for designing more acceptable devices and advancing exposure research. We systematically evaluated the usability acceptability of a dosimeter (lido) 29 participants who wore near corneal plane eye 5 days. Common reasons not wearing included exercise, recharging, wet environments, public places, discomfort. Despite these issues, adhered to using high compliance (89% recording time). Our findings revealed significant discrepancy between mean (300 lx

Language: Английский

Citations

2
Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review DOI Open Access
Antonio Almendros-Ruiz, Alejandro López-Moro, Javier Conde-Pipò

et al.

Published: Sept. 13, 2023

Background: to know the existing documentation related exogenous melatonin in performance of professional soccer players. Methods: critical and systematic review. Data were obtained by looking up following bibliographic data bases: Web Science, MEDLINE (via PubMed), Embase, Cochrane Library Scopus. The used terms "Soccer Athlete", "Melatonin" Performance", using as a filter: "Humans". search update was May 2023. Results: having applied inclusion exclusion criteria, 8 articles selected out 59 retrieved references. dose administered studies ranged between 5 mg. outcomes showed decrease oxidative stress, muscle damage inflammatory markers melatonin-treated group. Conclusions: Exogenously seems attenuate some effects derived from physical exercise such inflammation players, since it has no potential adverse effects, could be interesting apply this population. However, direct supplementation on have not been demonstrated, so more research is needed intervention period, effective larger participant populations.

Language: Английский

Citations

6
The Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review DOI Open Access
Antonio Almendros-Ruiz, Alejandro López-Moro, Javier Conde-Pipò

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4467 - 4467

Published: Oct. 21, 2023

Background: Melatonin is a hormone that has shown anti-inflammatory actions, reduced oxidative stress, and effects on physical performance, so the aim of this study was to review melatonin supplementation performance professional soccer players. Methods: Critical systematic review. Data were obtained by performing searches in following bibliographic databases: Web Science, MEDLINE (via PubMed), Embase, Cochrane Library, Scopus. The terms used “Soccer Athlete”, “Melatonin”, Performance”, using “Humans” as filter. search update May 2023. Results: Having applied inclusion exclusion criteria, eight articles selected out 59 retrieved references. dose administered studies ranged between 5 8 mg. outcomes showed decrease muscle damage, inflammatory markers melatonin-treated group. Conclusions: Exogenously seems attenuate some derived from exercise, such inflammation, football players, since it no potential adverse effects, could be interesting apply population. However, direct have not been demonstrated, more research needed intervention period effective with larger participant populations.

Language: Английский

Citations

4
Organic light-emitting diode therapy promotes longevity through the upregulation of SIRT1 in senescence-accelerated mouse prone 8 mice DOI Creative Commons

Yue-Hua Deng,

Chi‐Sheng Chiou,

Ching-Yu Tsai

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2024, Volume and Issue: 257, P. 112957 - 112957

Published: June 13, 2024

Phototherapy has been extensively used to prevent and treat signs of aging stimulate wound healing, phototherapy through light-emitting diodes (LEDs). In contrast LED, organic LED (OLED) devices are composed semiconductors that possess novel characteristics. We investigated the regenerative potential OLED for restoring cellular from senescence thus delaying animal aging. Bone marrow-derived stem cells (BMSCs) adipose-derived (ADSCs) were isolated control OLED- treated groups evaluate their proliferation, migration, differentiation potentials. Cellular was evaluated using a senescence-associated β-galactosidase (SA-β-gal) activity assay gene expression biomarker assessment. treatment significantly increased cell colony formation, migration abilities cells. SA-β-gal decreased in both ADSCs BMSCs OLED-treated group. Gene biomarkers mice indicated significant upregulation IGF-1 (insulin growthfactor-1). The SIRT1 inhibited p16 p19 genes then downregulate p53 expressions regeneration Our findings survival rates 10-month senescence-accelerated mouse prone 8 prolonged gross appearance improved markedly after treatment. Histological analysis skin brain tissue also greater collagen fibers density, which prevents ocular abnormalities β-amyloid accumulation. Lordokyphosis bone characteristics observed resemble those younger conclusion, therapy reduced enhanced stem-cell recovery could be regeneration.

Language: Английский

Citations

1
Impact of Blue Light Intervention on Physiological Parameters and Circadian Rhythms: Insights from a Wistar Rat Model Study DOI Creative Commons
Nazmin Fatima, Gyanendra Kumar Sonkar, Sangeeta Singh

et al.

Biomedical and Biotechnology Research Journal (BBRJ), Journal Year: 2024, Volume and Issue: 8(2), P. 160 - 165

Published: April 1, 2024

Abstract Background: This study investigates the impact of blue light-emitting diode (LED) lighting on physiological responses Wistar rats. The circadian system plays a vital role in regulating functions, allowing organisms to anticipate and adapt environmental rhythms. synchronization endogenous clocks with external cues, such as light-dark cycles, is essential for optimal performance. However, emerging technologies, like LED lighting, present new challenges rhythms, highlighting need continued research this area. Methods: study, approved by Animal Ethics Committee, involved total 12 male rats, which were divided into two groups: Control group light (BL) treated group, each consisting six BL model was established subjecting rats h exposure daily period 3 months. Half sacrificed at end period, while remaining transitioned normal (NL) conditions another months before being euthanized. Blood tissue samples collected analysis, including measurements body weight, blood glucose, insulin, melatonin, lipid profile, well messenger RNA expression reverse transcription-polymerase chain reaction global DNA methylation enzyme-linked immunosorbent assay. Results: found that led higher monthly increase elevated glucose levels, decreased insulin melatonin levels compared controls. also caused decrease cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein. Gene analysis revealed downregulation Period1, Cryptochrome1, brain muscle arnt-like protein 1 (Bmal1) hypothalamus, significant upregulation upon returning NL conditions. induced hypermethylation sequences, partially reverted after Conclusion: Our reveals broad BL/artificial contributing incidence obesity metabolic disorders. With rise blue-rich more needed understand its long-term effects health. contributes deeper understanding intricate relationship between health, emphasizing importance informed decisions regarding technologies mitigate potential health risks.

Language: Английский

Citations

1
Towards an evidence-based integrative lighting score: a proposed multi-level approach DOI Creative Commons
Oliver Stefani, Isabel Schöllhorn, Mirjam Münch

et al.

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: July 25, 2024

Human circadian clocks are synchronized daily with the external light-dark cycle and entrained to 24-hour day. There is increasing evidence that a lack of synchronization entrainment can lead adverse health effects. Beyond vision, light plays critical role in modulating many so-called non-visual functions, including sleep-wake cycles, alertness, mood endocrine functions. To assess (and potentially optimize) impact on it necessary know exact 'dose' (i.e. spectral irradiance exposure duration at eye level) exposures, but also include metadata about lighting environment, individual needs resources.

Language: Английский

Citations

1
Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation DOI Creative Commons

Johanna Giuranna,

Yiran Zheng, M. Brandt

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

The C-terminal binding protein 2 (CTBP2) gene (translational isoforms: CTBP2-L/S, RIBEYE) had been identified by a cross-trait analysis of genome-wide association studies for anorexia nervosa (AN) and body mass index (BMI). Here, we did mutation in CTBP2 performing polymerase chain reactions with subsequent Sanger-sequencing to identify variants relevant AN weight regulation ensued functional studies. Analysis the coding regions 462 female patients (acute or recovered), 490 children adolescents severe obesity, 445 healthy-lean adult individuals 168 healthy normal detected 24 located specific exon RIBEYE. In initial analysis, three these were rare non-synonymous (NSVs) heterozygously (p.Arg72Trp - rs146900874; p.Val289Met -rs375685611 p.Gly362Arg rs202010294). Four NSVs one heterozygous frameshift variant exclusively obesity (p.Pro53Ser rs150867595; p.Gln175ArgfsTer45 rs141864737; p.Leu310Val rs769811964; p.Pro397Ala rs76134089 p.Pro402Ser rs113477585). Ribeye mRNA was mouse hypothalamus. No effect fasting overfeeding on murine hypothalamic expression determined. Yet, increased hypothalami leptin-treated Lep

Language: Английский

Citations

1
Playing outdoor during preschool might help reduce risk of school‐age obesity DOI Open Access
Mai-Lis Hellénius

Acta Paediatrica, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 10, 2024

The Japanese researchers Tsuge Takahiro and co-authors present a large population-based cohort study showing that outdoor play habits during preschool years are associated with reduced risk of obesity in school-age children.1 authors suggest parents caregivers should encourage children at an early age, as this may help prevent later life. originates from targeting all babies born Japan between January 10 to 17 July 17, 2001. Baseline questionnaires were sent total 53 575 families when eligible reached the age 6 months, 47 015 completed questionnaire (88%). Thereafter follow-up annually. responded question 'Where do your usually play' asked select applicable answers following options: 'in my garden or on grounds apartment complex', parks', natural areas such fields, forests beaches', 'on street', shrines temples', playgrounds department stores supermarkets', 'other', 'don't anywhere but inside home'. All responses except home' classified exposure activity. reported 2.5 was used parent-reported height weight 7 for identification overweight according WHO references. Logistic regression models estimate odds ratios associations obesity. Some relevant parental child factors, example education, income status smoking children's birthweight nursery school attendance 3.5 adjusted for. For some data missing activities (4203) lost (11 069) leaving 31 743 inclusion analysis. Most (91%) having activity 10% (WHO BMI SD score >1.0) years. Outdoor negatively (adjusted OR 0.85, 95% confidence interval [CI]: 0.74–0.97). is interesting important against background pandemic we see today form sedentary lifestyle physical well increasing body young people.2, 3 combination weak muscles, sarcopenic obesity, now also being recognised children.4 Sarcopenic has been strong factor premature death adults old adults. Sedentary behaviour inactivity resulting energy consumption indeed contributors rise factors many common mental illnesses. Early childhood period rapid cognitive development. Lifestyle formed mostly within families. Furthermore, new advanced techniques have learned disease processes like atherosclerosis start very Of course, responsibility cannot be placed parents. Society needs take greater facilitating Decision-makers national local level, urban planners architects, need build opportunities neighbourhoods other places stay day. Global Action Plan Physical Activity (GAPPA) 2018–2030, Area providing programmes activity, clearly shows there potential improvement respect.5 Parents gain knowledge about importance development growth, health well-being. facilitate possibility physically active Having opportunity move outdoors moving playing increases consumption, which reduces It daylight. Research area limited, studies indicate movement UV light leads further increase more pronounced effects composition. Sun several positive sleep, circadian rhythm metabolic physiology.6, current adds rapidly growing area. Clearly, it urgent find effective strategies promote their Being able inspiring safe environments right children. Mai-Lis Hellenius: Conceptualization; visualization; writing – original draft; review editing.

Language: Английский

Citations

1
Effects of light, electromagnetic fields and water on biological rhythms DOI Creative Commons
Jan Martel, Nicolas Rouleau, Nirosha J. Murugan

et al.

Biomedical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 100824 - 100824

Published: Dec. 1, 2024

The circadian rhythm controls a wide range of functions in the human body and is required for optimal health. Disruption can produce inflammation initiate or aggravate chronic diseases. modern lifestyle involves long indoor hours under artificial lighting conditions as well eating, working, sleeping at irregular times, which disrupt lead to poor health outcomes. Seasonal solar variations, sunspot cycle anthropogenic electromagnetic fields also influence biological rhythms. possible mechanisms underlying these effects are discussed, include resonance, radical-pair formation retina cryptochromes, ion cyclotron interference, ultimately leading variations melatonin cortisol. Intracellular water, represents coherent, ordered phase that sensitive infrared light fields, may respond man-made fields. We describe here various factors affect regulation rhythms, with aim providing practical measures improve

Language: Английский

Citations

1