In vivo and In silico Insights into the Anti-Diabetic Efficacy of EVOO and Hydroxytyrosol in a Rat Model DOI
Mahmoud Gamal, Mohamed A. Awad, Azizeh Shadidizaji

et al.

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 135, P. 109775 - 109775

Published: Oct. 5, 2024

Language: Английский

Analysis of anti-aging activity of Chinese perfume (Aglaia odorata) and Indian camphorweed (Pluchea indica) leaves using Saccharomyces cerevisiae model system DOI Open Access
Woro Anindito Sri Tunjung,

Lovy Perdani,

Nudia Mufidah Azasi

et al.

Journal of Research in Pharmacy, Journal Year: 2025, Volume and Issue: 29(1), P. 396 - 406

Published: March 3, 2025

This study examined the anti-aging effect of Chinese perfume (Aglaia odorata) and Indian camphorweed (Pluchea indica) leaf extracts on Saccharomyces cerevisiae as a model system. Investigation antioxidant activity bioactive compounds using GC–MS qualitative spot tests were performed to determine effects. In addition, quantitative test was conducted high-throughput chronological lifespan analysis. The results showed that enzyme activities SOD, APX, CAT in leaves 393.96 units/min/g FW, 215 µmoles H2O2/min/g 5.6 H2O2 decomposed/min/g respectively; values 717.57 48 12.33 µmole respectively. 577.2 µg/mL 348.86 µg/mL. extract included n-hexadecanoic acid, β turmerone, 2-propenoic 3-phenyl-, methyl ester (methyl cinnamate) those from acid neophytadiene. Treatment with both prolonged life yeast after 15 days incubation. stress conditions, yeasts better growth addition extracts. revealed demonstrate promising potential ingredients for cosmetics.

Language: Английский

Citations

0

Hydroxytyrosol N-alkylcarbamate conjugates as antitrypanosomal and antileishmanial agents DOI

Belinda Jimenez-Martin,

Diego A Guerra-Arias,

Antonio Martı́nez

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 159, P. 108354 - 108354

Published: March 12, 2025

Language: Английский

Citations

0

Dietary Polyphenols as Geroprotective Compounds: From Blue Zones to Hallmarks of Ageing DOI Creative Commons
Sergio Davinelli, Alessandro Medoro, Frank B. Hu

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102733 - 102733

Published: March 1, 2025

Language: Английский

Citations

0

Global Status, Recent Trends, and Knowledge Mapping of Olive Bioactivity Research Through Bibliometric Analysis (2000–2024) DOI Creative Commons
Manuel Garrido‐Romero, Marina Díez‐Municio, F. Javier Moreno

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(8), P. 1349 - 1349

Published: April 14, 2025

Over the past two decades, both academic and industrial interest in olive bioactive compounds has grown significantly due to their remarkable health benefits, such as antioxidant, anti-inflammatory, cardioprotective properties. These compounds, found fruit leaves, have become a central focus research on functional foods nutraceuticals. A comprehensive bibliometric analysis of scientific publications from 2000 2024 highlights notable increase this field, with 2228 documents published high-impact journals an estimated annual growth rate 0.2694 year−1, particularly last decade. This surge reflects growing recognition compounds’ potential promoting human through nutritional therapeutic interventions, role expanding nutraceutical industry. is further reaffirmed by patent analysis, which shows significant rise filings related compounds. The also examined nearly 6000 keywords identify most influential domains, pinpoint knowledge gaps, reveal important olives preventing various diseases.

Language: Английский

Citations

0

Synthesis and Health Effects of Phenolic Compounds: A Focus on Tyrosol, Hydroxytyrosol, and 3,4-Dihydroxyacetophenone DOI Creative Commons
Wenyu Wang, Lixin Du,

Qidong Wei

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 476 - 476

Published: April 16, 2025

Tyrosol (Tyr), hydroxytyrosol (TH), and 3,4-Dihydroxyacetophenone (3,4-DHAP) are three phenolic compounds naturally present in plants that have attracted considerable research attention due to their potent antioxidant, anti-inflammatory, anticancer, cardiovascular protective properties. In recent years, mounting evidence has indicated these hold broad potential both disease prevention treatment. This paper reviews the chemical structures synthetic methods of Tyr, HT, 3,4-DHAP, as well multifaceted effects on human health, particularly roles mechanisms antioxidation, anti-inflammation, protection, neuroprotection, anticancer activity. addition, this explores future prospects current challenges associated with application—such low bioavailability long-term safety concerns—and proposes directions for further investigation.

Language: Английский

Citations

0

Olive oil and its derivatives for promoting performance, health, and struggling thermal stress effects on broilers DOI Creative Commons
Zeinab M.H. Mahasneh, Sameh A. Abdelnour,

Alia Ebrahim

et al.

Poultry Science, Journal Year: 2023, Volume and Issue: 103(2), P. 103348 - 103348

Published: Dec. 5, 2023

Olive oil (OL) production is the most significant agro-industrial business and has a high impact on economy of numerous Mediterranean countries. However, OL extraction results in massive amounts byproducts, including solid residue (olive cake or olive pomace) an aqueous stage mill wastewater), which have serious environmental effects due to their hazardous nature excessive organic content. Despite these byproducts causing pollution, they can be applied for animal feeding. According literature, its derivatives been used promote broiler performance, feed utilization, health status broilers as growth promoters protein sources. Furthermore, using could improve heat resistance stressed via struggling thermal stress effects. In this framework, we highlighted use feeding performance status. Additionally, role combating investigated sustainable strategy promoting circular industry.

Language: Английский

Citations

9

Iridoids modulate inflammation in diabetic kidney disease: A review DOI

Tongyi Zhou,

Na Tian,

Liu Li

et al.

Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 22(3), P. 210 - 222

Published: March 28, 2024

Language: Английский

Citations

3

Cellular Senescence: The Driving Force of Musculoskeletal Diseases DOI Creative Commons

Angela Falvino,

Beatrice Gasperini, Ida Cariati

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 1948 - 1948

Published: Aug. 26, 2024

The aging of the world population is closely associated with an increased prevalence musculoskeletal disorders, such as osteoporosis, sarcopenia, and osteoarthritis, due to common genetic, endocrine, mechanical risk factors. These conditions are characterized by degeneration bone, muscle, cartilage tissue, resulting in fractures reduced mobility. Importantly, a crucial role pathophysiology these diseases has been proposed for cellular senescence, state irreversible cell cycle arrest induced factors DNA damage, telomere shortening, mitochondrial dysfunction. In addition, senescent cells secrete pro-inflammatory molecules, called senescence-associated secretory phenotype (SASP), which can alter tissue homeostasis promote disease progression. Undoubtedly, targeting their profiles could development integrated strategies, including regular exercise balanced diet or use senolytics senomorphs, improve quality life population. Therefore, our review aimed highlight senescence age-related diseases, summarizing main underlying mechanisms potential anti-senescence strategies treatment osteoarthritis.

Language: Английский

Citations

3

Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components DOI
Vittorio Calabrese, Naomi Osakabe, Rosalba Siracusa

et al.

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111960 - 111960

Published: July 5, 2024

Language: Английский

Citations

2

Functional foods in Mediterranean diet: exploring the functional features of vegetable case-studies obtained also by biotechnological approaches DOI Creative Commons
Anna Rita Bavaro,

Annamaria Tarantini,

Angelica Bruno

et al.

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: Oct. 16, 2024

The Mediterranean Diet (MedDiet) is a widely recognized dietary pattern, with its effects largely attributed to "functional foods" which are able positively influence one or more target functions, improving health and maintaining state of well-being.In this review, three "case-study" typical the MedDiet, such as artichokes, capers table olives considered traditional functional vegetables rich in bioactive compounds, mainly polyphenols. review extensively discusses antioxidant these molecules, well their role aging prevention reduction, human health, influencing abundance composition intestinal microbiota. Additionally, focuses on fate polyphenols along digestive tract.Among biotechnological strategies, explores fermentation process modifying biochemical profile, recovery, bioaccessibility bioavailability compounds present some vegetable foods MedDiet. Finally, main challenges selection, addition, maintenance probiotic strains food products also summarized, view develop new carriers for diets".

Language: Английский

Citations

2