Ganoderma Lucidum Polysaccharides: A Comprehensive Overview of Pharmacological Effects and Future Perspectives

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105990 - 105990

Published: Jan. 1, 2025

Language: Английский

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Phytochemical Profile and Anticancer Potential of Helichrysum arenarium Extracts on Glioblastoma, Bladder Cancer, and Breast Cancer Cells

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 144 - 144

Published: Jan. 22, 2025

Background/Objectives: Cancer is the second leading cause of death globally. Medicinal plants have emerged as fundamental sources bioactive compounds with anticancer potential, largely attributed to their diverse secondary metabolites. This study aimed investigate cytotoxic effects Helichrysum arenarium extracts from two distinct regions Turkiye, Mersin, and Artvin, on cancerous (MDA-MB-231, RT4, T98G) non-cancerous (ARPE-19, hGF) cell lines identify responsible for these effects. Methods: H. plant were prepared using ethanol methanol solvents, followed by lyophilization dissolution in DMSO. The evaluated Hoechst staining MTS assays assess viability. IC50 values selectivity indices calculated. Phytochemical composition was analyzed Quadrupole Time-of-Flight mass spectrometry. Results: extract Mersin (HAE-M) demonstrated superior cytotoxicity, particularly against breast bladder cancer cells, while showing minimal impact cells. HAM-M, HAE-A, HAM-A exhibited comparatively less potent analysis HAE-M identified 16 compounds, including Naringenin, Luteolin, Quercitrin, known antioxidant properties. Conclusions: These findings highlight potential extracts, HAE-M, a source agents. novel its comprehensive different extraction methods regional sources, combined phytochemical profiling, selective Further investigations into mechanisms action could contribute development plant-derived therapies.

Language: Английский

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Structure–function insights of natural Ganoderma polysaccharides: advances in biosynthesis and functional food applications

Natural Products and Bioprospecting, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 4, 2025

Abstract Ganoderma polysaccharides (GPs), derived from various species of the genus, exhibit diverse bioactivities, including immune modulation, anti-tumor effects, and gut microbiota regulation. These properties position GPs as dual-purpose agents for medicinal functional food development. This review comprehensively explores structural complexity six key their specific mechanisms action, such TLR signaling in apoptosis pathways activity, prebiotic effects on microbiota. Additionally, structure–activity relationships (SARs) are highlighted to elucidate biological efficacy. Advances green extraction techniques, ultrasonic-assisted enzymatic methods, discussed roles enhancing yield aligning with sustainable production principles. Furthermore, addresses biotechnological innovations polysaccharide biosynthesis, improving efficiency making large-scale feasible. insights, combined ongoing research into bioactivity, provide a solid foundation developing health-promoting products that incorporate GPs. future directions suggested optimize biosynthesis fully harness health benefits these polysaccharides. Graphical abstract

Language: Английский

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Ganoderic Acid Ameliorates Ulcerative Colitis by Improving Intestinal Barrier Function via Gut Microbiota Modulation

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2466 - 2466

Published: March 10, 2025

Ulcerative colitis (UC) is a chronic and recurrent gastrointestinal disease that affects millions of humans worldwide imposes huge social economic burden. It necessary to find safe efficient drugs for preventing treating UC. The aim this study was determine whether ganoderic acid (GA), the main bioactive components Ganoderma lucidum, has preventive therapeutic effect on UC in dextran sulfate sodium (DSS)-induced mouse model. Our experimental results showed GA significantly ameliorated body weight loss activity index (DAI) mice. restored 11% colon length 69% spleen compared decreased intestinal inflammatory response improved barrier function intestine by upregulating tight junction proteins Zonula occludens-1 (ZO-1), occludin claudin-1. A co-housing experiment gut microbiota accounted UC, which confirmed fecal transplantation from GA-treated mice Furthermore, 16S rDNA high-throughput sequencing bacteria enriched abundance Lactobacillus, Oscillospira, Odoribacter Ruminococcus, were positively correlated with length. found functional metabolites, including Indole-3-acetaldehyde (IAAld), Glutamine (Gln) Glutathione (GSH), reduced damage Caco-2 cell In conclusion, suggests could ameliorate improving via modulating associated metabolites.

Language: Английский

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Unlocking the Potential of Ganoderma lucidum (Curtis): Botanical Overview, Therapeutic Applications, and Nanotechnological Advances

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 422 - 422

Published: March 26, 2025

Background: Ganoderma lucidum (GL), commonly known as the “Lingzhi” or “Reishi” mushroom, has long been recognized for its potential health benefits and medicinal properties in traditional Chinese medicine. The unique combination of bioactive compounds present GL, such triterpenoids, polysaccharides, peptides, inspired interest leveraging their therapeutic In recent years, emerging field nanotechnology opened up new possibilities using remarkable GL at nanoscale. Objetive: main objective this review is to explore innovative therapies, particularly cancer treatment, assess how nanotechnology-based strategies can enhance applications.is explore. Results: Nanotechnology-based have investigated efficient extraction purification from GL. Additionally, nanocarriers nanoformulations developed protect these sensitive degradation, ensuring stability during storage transportation. use GL-based nanomaterials shown promising results several biomedical applications, namely due anticancer activity by targeting cells, inducing apoptosis, inhibiting tumor growth. Conclusions: presents an exciting frontier development novel applications. Nevertheless, further research interdisciplinary are warranted fully exploit synergistic offered nanotechnology. Future prospects include robust clinical trials focused on therapies clarify mechanisms actions optimize formulations, ultimately leading solutions human well-being.

Language: Английский

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Fungal Biomolecules as Nutraceuticals

Published: Jan. 1, 2025

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Comprehensive profiling of xanthine oxidase inhibitors of Changbaishan ganoderma and its treatment of Gout disease

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142446 - 142446

Published: April 1, 2025

Language: Английский

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The application and perspective of NMR and MS based strategies for functional compounds mining in medicinal and dietary plants

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 26, 2024

Medicinal and dietary plants provide numerous nutritional functional compounds also have various potential health benefits to humanity. The specific efficient techniques for accurate identification of metabolites is crucial the development foods from medicinal plants. Nuclear magnetic resonance (NMR) mass spectrometry (MS) are indispensable essential technologies that an unsurpassed wealth untargeted identification, quantitative qualitative analysis, structural information in study food plant products. In past decade, rapid modern analytical technology has led emergence new approaches strategies natural products discovery. Especially application novel NMR- MS-based dereplication aided by artificial intelligence machine learning algorithms brought about a significant shift discovery process. These developments changes filed given us insights into how accurately target mining nutritional, functional, bioactive compounds. Thus, we summarized recent research on NMR MS based methods focusing compounds, mainly This review could comprehensive perspective better understanding technologies, which valuable ideas mining.

Language: Английский

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Synthesis, characterization and MAFLD prevention potential of Ganoderma lucidum spore polysaccharide-stabilized selenium nanoparticles

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136962 - 136962

Published: Oct. 28, 2024

Language: Английский

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Inhibition of Proliferation and Induction of Apoptosis in Prostatic Carcinoma DU145 Cells by Polysaccharides from Yunnan Rosa roxburghii Tratt

Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1575 - 1575

Published: April 1, 2024

Objective: This study aimed to investigate methodologies for the extraction and purification of polysaccharides from Rosa roxburghii Tratt fruits their impact on various cellular processes in prostate cancer DU145 cells, including survival rate, migration, invasion, cell cycle, apoptosis. Results: Compared control group, polysaccharide exhibited a significant reduction viability, invasion rates cells time- dose-dependent manner within polysaccharide-treated groups. Additionally, it effectively arrested cycle at G0/G1 phase by downregulating expressions CDK-4, CDK-6, Cyclin D1. Furthermore, induced apoptosis upregulating Caspase 3, 8, 9, BAX. Methods: Polysaccharides were extracted sourced Yunnan, China. Extraction decolorization methods optimized using response surface methodology, based single-factor experiment. Polysaccharide was carried out DEAE-52 cellulose Sephadex G-100 column chromatography. The optimal dosage R. affecting determined CCK-8 assay. Cell migration assessed transwell scratch assays. Flow cytometry employed analyze effects Western blotting Quantitative real-time PCR utilized examine protein mRNA respectively. Conclusions: polysaccharides, consisting D-mannose, L-rhamnose, N-acetyl-D-glucosamine, D-galacturonic acid, D-glucose, D-galactcose, D-xylose, L-arabinose, L-fucose, possess ability hinder proliferation, while inducing through modulation relevant gene expressions.

Language: Английский

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