Toxicity study of mineral medicine haematitum

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118406 - 118406

Published: June 3, 2024

Language: Английский

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Zinc-modulated Bidirectional Copper Transfer Across the Blood-Brain Barrier in a Porcine Brain Capillary Endothelial Cell Culture Model System

Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 86, P. 127547 - 127547

Published: Oct. 19, 2024

Language: Английский

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The role of zinc in the premature brain: functions, outcomes and future research perspectives

Frontiers in Pediatrics, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 23, 2024

Zinc (Zn) is one of the most prevalent and essential micronutrients, found in 10% all human proteins involved numerous cellular enzymatic pathways. Zn important neonatal brain, due to its involvement neurotransmission, synaptic plasticity, neural signaling. It acts as a neuronal modulator highly concentrated certain brain regions, such hippocampus, retina. Low intake frequent several countries populations with high poverty index. Preterm infants are at risk for deficiency prenatal (missing fetal Zn) postnatal reasons (less intestinal absorption insufficient maternal milk match accretion). The amount needed preterm not known remains subject controversy. Recent nutritional recommendations favored an increase daily supplementation. Systematic reviews randomized trials have shown that supplementation increases weight gain may decrease mortality. In this review we will summarize role functions outcomes newborns, gaps knowledge areas future research.

Language: Английский

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Influence of trace elements changes in the cerebellum on the rat’s behavior in elevated plus maze in the early period of mild blast-induced traumatic brain injury

Pathologia, Journal Year: 2024, Volume and Issue: 21(1), P. 28 - 33

Published: April 22, 2024

The aim of the current study was to determine whether there are changes in brain trace elements rats with blast-induced trauma and if these affect behavior elevated plus maze. Materials methods. carried out on 126 sexually mature male Wistar were divided into 3 groups: Experimental – exposed a shock wave 26.4 ± 3.6 kPa (n = 42); Sham 42), animals which subjected inhalation anesthesia halothane fixation horizontal position; Intact 42). Behavior duration presence open closed arms, number stands, grooming recorded all groups for minutes. After, euthanized halothane, followed by removal brain. cerebellum completely separated spectral analysis using energy dispersive X-ray fluorescence (EDRFA) analyzer EXPERT XL. Results. Results showed significant cognitive activity experimental group indicate functional disorders form maladaptation space subsequent inhibition motor centers. Cu/Fe ratio decreased 14th 21st days increased 28th. Cu/Zn day. Zn/Fe higher 28th days. existence correlations between behavioral established. Conclusions. In early period traumatic injury, cerebellar dysfunction spatial depression centers observed Correlation different strengths directions relationships ratios Cu/Fe, indicators maze (duration stay vertical activity) rats.

Language: Английский

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Novel Cosolvent-Dependent Electrochemical Sensing Behavior of a Pair of Isostructural Ionic Nickel(Ii) Coordination Polymers

Published: Jan. 1, 2024

Language: Английский

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Iron Trace Elements Concentration in PM10 and Alzheimer’s Disease in Lima, Peru: Ecological Study

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2043 - 2043

Published: Sept. 8, 2024

Alzheimer’s disease (AD) has been linked to air pollution, especially particulate matter (PM). PM comprises various elements, including iron-rich particles that may reach the brain through inhalation. Lima, Peru is one of most polluted cities in Latin America, with a high rate AD. The study aims evaluate association between iron (Fe) trace elements PM10 and AD cases Peru. This retrospective ecological used monthly Fe concentration data from Peruvian Ministry Health. (ICD-10-G30) dementia (DAD, ICD-10-F00) were obtained CDC. element available for six districts Lima years 2017–2019 2022. Cases standardized based on ≥60-year-old populations each district. Hierarchical mixed-effects models Gaussian negative binomial families constructed both outcomes jointly (AD + DAD) separately (AD, DAD). A sensitivity analysis was conducted by excluding Lima’s downtown In complete model, log-Fe associated higher DAD DAD, IRR three outcomes. After controlling other metals, observed (β-coeff = 6.76, 95%CI 0.07; 13.46, p 0.048), (1.55, 1.09; 2.20, 0.014) (1.83, 1.21; 2.78, 0.004). not significant analysis. conclusion, exposure inhalation be presence Lima.

Language: Английский

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Channeling hope for uranium-induced kidney damage and beyond with TRPML1

Cell Calcium, Journal Year: 2023, Volume and Issue: 115, P. 102799 - 102799

Published: Sept. 11, 2023

Language: Английский

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