Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8250 - 8250

Published: July 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Language: Английский

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Beneficial microbiome and diet interplay in early-onset colorectal cancer

EMBO Molecular Medicine, Journal Year: 2024, Volume and Issue: 17(1), P. 9 - 30

Published: Dec. 9, 2024

Language: Английский

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Global deletion of the immune cell transcription factor, T-bet, alters gut microbiota and insulin sensitivity in mice

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 27, 2024

The gut microbiota plays a role in energy homeostasis: its composition differs lean and obese mice may impact insulin sensitivity. immune system has co-evolved with the microbiota, but direct regulation of microbial communities by metabolic is unclear. Mice lacking cell specific transcription factor T-bet (Tbx21) are sensitive. Compared wild-type mice,

Language: Английский

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Inflammatory and intestinal permeability biomarkers in healthy participants on long term vegan, vegetarian, omnivore and low-carbohydrate high-fat diet

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Oct. 12, 2023

Abstract Vegan, vegetarian and low-carbohydrate high fat (LCHF) diets can all offer several health benefits, if food choices are appropriate. In most studies examining their effects on systemic inflammation, participants were either overweight, a weight loss programme or not matched for BMI, had pre-existing condition such as type 2 diabetes mellitus hypertension. Little is known about the of dietary patterns healthy normal individuals. The aim present study was therefore to assess directly compare inflammatory intestinal permeability status in following aforementioned omnivore diet at least 6 months. this cross-sectional study, we measured biomarkers IL-6, TNF-α CRP, markers LBP zonulin, along with analysis lifestyle aspects, intakes physical activity, 89 participants. groups sex, age BMI. There no differences any parameters between four found strong correlations intakes. Using cluster analysis, divided into eight clusters more less favourable profiles; contained representatives represented each cluster. Significant intake mono-unsaturated fatty acids, ω-3/ω-6 ratio, phase angle working two shifts. healthy, normal-weight individuals, does depend pattern itself, but rather complexly regulated associated non-dietary factors.

Language: Английский

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Gut microbiome and function are altered for individuals living in high fluoride concentration areas in Pakistan

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116959 - 116959

Published: Sept. 3, 2024

Endemic fluorosis refers to the condition when individuals are exposed excessive amounts of fluoride ion due living in a region characterized by elevated levels fluorine drinking water, food, and/or air. In Pakistan, substantial proportion population is thereby affected, posing public health concern.

Language: Английский

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