Potential Biomarkers and Treatment of Neuroinflammation in Parkinson's Disease

Actas Españolas de Psiquiatría, Journal Year: 2025, Volume and Issue: 53(1), P. 181 - 188

Published: Jan. 5, 2025

Parkinson's disease (PD) is a degenerative of the central nervous system primarily affecting middle-aged and elderly individuals, significantly compromising their quality life. Neuroinflammation now recognized as key feature in pathogenesis PD. This study reviews recent advances identification potential biomarkers associated with neuroinflammation PD significance for therapeutic strategies. These findings suggest that inflammatory factors play pivotal role treatment, interventions involving anti-inflammatory drugs, physical exercise, dietary modifications have shown promising results mitigating progression.

Language: Английский

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The Role of Intestinal Microbiota and Diet as Modulating Factors in the Course of Alzheimer’s and Parkinson’s Diseases

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 308 - 308

Published: Jan. 19, 2024

Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain-gut axis is an object that remains the target of modern research, it not without reason many enrich with diet in its name. Numerous connections mutual correlations have become basis for seeking answers questions pathology as well human physiology. Disorders this homeostasis dysbiosis itself accompany neurodegenerative diseases such Alzheimer's Parkinson's. Heavily dependent on external factors, modulation gut microbiome represents opportunity advance treatment Probiotic interventions, synbiotic or fecal transplantation can undoubtedly support biotherapeutic process. A special role played by diet, which provides metabolites directly affect body microbiota. holistic view organism therefore essential.

Language: Английский

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Application and Mechanism of Action of a Ketogenic Diet in Antiepileptic Therapy

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Epilepsy is a chronic neurological disorder caused by abnormal discharges of neurons in the brain, which seriously affects quality life patients. Although there are various drug treatments available, many epilepsy patients still experience seizures with effect drugs and develop refractory epilepsy. The ketogenic diet can treat drug-refractory regulating body's metabolism enhance improving their cognition, behavior, sleep quality. However, no unified conclusion on mechanism through plays therapeutic role This article provides review possible mechanisms how exerts protective

Language: Английский

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The impact of ketogenic diet on the frequency of psychogenic non‐epileptic seizures (PNES): A feasibility randomized pilot study

Epilepsia Open, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract The potential of dietary interventions, particularly the use ketogenic diet in patients with Psychogenic Non‐Epileptic Seizures (PNES), remains underexplored. This study aimed to assess feasibility a 6‐week (Modified Atkins Diet, MAD) intervention adult PNES and compare its effects on frequency other variables against control healthy (CD). A pilot randomized controlled trial was conducted at tertiary neurology hospital, enrolling outpatients diagnosed assigning them either MAD or CD. Baseline follow‐up assessments (at 2, 4, 6 weeks) included evaluation mental health, frequency, metabolic measures. Descriptive inferential methods, including repeated measures ANOVA, were used for statistical analysis. Seventeen (mean age 28.23 ± 7.1) randomly allocated receive ( n = 12) CD 5). entire sample exhibited significant decrease monthly p 0.01, Hedges ES 0.618) without differences between groups. group showed improvement depression, anxiety week six. Results demonstrate that implementation is feasible suggest it may reduce seizure symptoms depression anxiety. These findings warrant further investigation larger, powered studies efficacy. Plain Language Summary explored benefits Modified Diet (MAD) reducing psychogenic non‐epileptic seizures (PNES). results safe, well‐tolerated, occurrence PNES, as well modifications could be helpful complement treatment, though larger are necessary confirm these outcomes.

Language: Английский

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Gut microbiota: the indispensable player in neurodegenerative diseases

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(12), P. 7096 - 7108

Published: April 4, 2024

As one of the most urgent social and health problems in world, neurodegenerative diseases have always been interest to researchers. However, pathological mechanisms therapeutic approaches are not achieved. In addition established roles oxidative stress, inflammation immune response, changes gut microbiota also closely related pathogenesis diseases. Gut is central player gut-brain axis, dynamic bidirectional communication pathway between nervous system, emerging insights confirmed its indispensability development this review, we discuss complex relationship system from perspective axis; review mechanism for modulation different how dietary patterns affect via microbiota; prospect employment approach those © 2024 Society Chemical Industry.

Language: Английский

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Depression in Multiple Sclerosis: Lifestyle Interventions as an Additional Therapeutical Approach: A Narrative Review

Psychiatry International, Journal Year: 2025, Volume and Issue: 6(1), P. 34 - 34

Published: March 20, 2025

Depression is one of the most common comorbidities in people with multiple sclerosis, which reduces quality life and treatment adherence. It enhances risk disease relapse. After looking through literature, we summarized newest recommendations that might be helpful reducing depression severity by reviewing publications regarding sclerosis published last five years. Physical activity rehabilitation should recommended. The ketogenic diet showed promising results, yet there are possible health concerns evolve after a longer period only carried out under medical supervision. Mindfulness cognitive dialectical behavior therapy reduce can recommended to depressive sclerosis.

Language: Английский

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Ketogenic diet as a brain-targeted therapy in psychogenic nonepileptic seizures: A neuroimaging findings-based nutritional hypothesis

Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111625 - 111625

Published: April 1, 2025

Language: Английский

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Investigating the Therapeutic Potential of the Ketogenic Diet in Modulating Neurodegenerative Pathophysiology: An Interdisciplinary Approach

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1268 - 1268

Published: April 4, 2025

The ketogenic diet (KD) is a dietary intervention comprising high-fat, low-carbohydrate, and moderate-protein intake designed to induce metabolic state known as ketosis, whereby ketone bodies are produced an alternative source of energy. Initially established treatment for intractable epilepsy, the KD has subsequently gained significant attention its potential manage neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's disease. Ketone bodies, such beta-hydroxybutyrate (BHB), have been demonstrated possess neuroprotective properties. increasing prevalence disease, poses public health challenge worldwide. With neurological disorders being second-leading cause death globally, need effective therapeutic interventions never more urgent. Recent evidence suggests that interventions, particularly diet, offer promising in mitigating progression these diseases by influencing processes providing benefits. characterized high-fat low-carbohydrate intake, induces leading production like beta-hydroxybutyrate, which enhance mitochondrial efficiency, reduce oxidative stress, modulate inflammatory pathways-mechanisms critical pathophysiology. This review explores role managing conditions, examining mechanisms action, historical context, efficacy. paper also discusses emerging linking improved cognitive function, reduced motor symptoms, enhanced activity patients with disorders. Additionally, highlights further research refine applications investigate impact on various better understand long-term effects. study underscores importance nutrition vital aspect strategy advocating continued exploration improve brain function.

Language: Английский

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Association between ketogenic diets and depression: A cross-sectional analysis of the NHANES 2005–2023 August

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Food and Nutrition in Autistic Adults: Knowledge Gaps and Future Perspectives

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1456 - 1456

Published: April 26, 2025

Proper nutrition is a critical component in supporting the overall health and development of individuals with autism spectrum disorder (ASD) who experience eating difficulties associated their autistic traits. Evidence regarding prevalence, origins, consequences issues related to ASD largely derived from studies on children, while information pertaining adults remains scarce. It therefore essential critically review existing research focusing draw robust conclusions identify clear gaps. A computer-aided search PubMed, Science Direct, Scopus, Web databases spanning years 2013-2024 using terms covering ASD/Autism, Adult, Nutrition/Nutritional Status, Diet yielded 43 full-text articles. In our literature review, we explored three aspects ASD: food preferences sensory processing patterns, nutritional status, whether dietary interventions have improved adherence healthier diets. Autistic appear select based perceptions. This selection pattern can affect tendency toward overweight deficiencies. The most promising intervention strategies incorporate adaptation structured meal planning. Further should apply rigorous methodologies that account for this population's specific characteristics.

Language: Английский

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