The role of maternal secretor status and human milk oligosaccharides on early childhood development: A systematic review and meta-analysis DOI Creative Commons
Martin M. Mulinge, Hellen K. Abisi, Hellen M. Kabahweza

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 3, 2023

ABSTRACT Breast milk is the gold standard of infant nutrition, delivering nutrients and bioactive molecules as needed to support optimal growth neurodevelopment. Increasing evidence links human oligosaccharides (HMOs) these early childhood development milestones. In this PRISMA-compliant systematic review meta-analysis, we summarised on HMOs brain development, physical growth, cognitive development. addition, compared HMO concentrations between secretor non-secretor mothers. Searches in PubMed, Scopus, Web Science yielded 245 articles, 27 which were included 12 meta-analysis. The meta-analysis revealed a substantial between-study heterogeneity, I 2 = 97.3%. pooled effect was 0.21 (95% CI, −0.41 - 0.83), p 0.484, indicating that secretors had higher concentrations, though difference not statistically significant. At one month age, 2’FL, 3FL, 3’SL play an important role maturation thus critical Secretors secrete 2’FL 3’SL, explaining benefits infants Growth velocity correlated fucosylated sialylated with lower linked stunting. conclusion, from systematically reviewed articles indicates are for child’s but extent they have impact dependent maternal status.

Language: Английский

The Role of Maternal Secretor Status and Human Milk Oligosaccharides on Early Childhood Development: A Systematic Review and Meta-Analysis DOI
Martin M. Mulinge, Hellen K. Abisi, Hellen M. Kabahweza

et al.

Breastfeeding Medicine, Journal Year: 2024, Volume and Issue: 19(6), P. 409 - 424

Published: April 5, 2024

Breast milk is the gold standard of infant nutrition, delivering nutrients and bioactive molecules as needed to support optimal growth cognitive development. Increasing evidence links human oligosaccharides (HMOs) these early childhood development milestones.

Language: Английский

Citations

7
High-Fat, High-Calorie Breast Milk in Women with Overweight or Obesity and Its Association with Maternal Serum Insulin Concentration and Triglycerides Levels DOI Creative Commons
Michael G. Ross,

Manasa P. Kavasery,

MacKenzie K. Cervantes

et al.

Children, Journal Year: 2024, Volume and Issue: 11(2), P. 141 - 141

Published: Jan. 23, 2024

The childhood obesity epidemic continues to be a challenge. Maternal and excessive infant weight gain are strong predictors of obesity, which itself is major risk factor for adult obesity. primary source nutrition during early life breast milk, its composition impacted by maternal habitus diet. We thus studied the relationship between BMI, serum lipids insulin, milk fat calorie content from foremilk hindmilk. Women who were exclusively breastfeeding at 7–8 weeks postpartum BMI classified as Normal (18.5–24.9, n = 9) women with Overweight/Obese (OW/OB ≥ 25, 13). blood continuous samples obtained hindmilk analyzed, intake was assessed. OW/OB had significantly higher in first last sample compared women. Amongst all women, triglycerides, HOMA correlated triglyceride concentration, suggesting that insulin action contribute human content. As has caloric implications growth these results suggest potential modulating reduction or insulin.

Language: Английский

Citations

5
Clinical significance and main parameters promoting the breast‑feeding strategy (Review) DOI Creative Commons

Eleni Nixarlidou,

Chrysoula Margioula‐Siarkou, Aristarchos Almperis

et al.

Medicine International, Journal Year: 2024, Volume and Issue: 4(2)

Published: Feb. 9, 2024

Breastfeeding provides numerous nutritional and immunological benefits, promotes neurological cognitive development, protects against chronic infectious diseases, rendering it beneficial to the survival well‑being of infants. According international recommendations, infants should be exclusively breastfed for first 6 months. However, despite global health recommendations funding initiatives, exclusive breastfeeding rates remain low worldwide. A number studies attribute factors that can grouped into demographic, psychosocial, economic midwifery factors, outline profile each mother who opts breastfeed her infant. In addition, previous pregnancies, induced labor, use epidurals at birth or possibility newborn being delivered prematurely, need admission an intensive care unit are reduce likelihood breastfeeding. Further research is required understand influencing initiation maintenance breastfeeding, as interventions have been ineffective. The aim present review was provide up‑to‑date summary these various in assist professionals policy makers developing effective with which promote support

Language: Английский

Citations

4
Breast Milk Macronutrient Content and Its Effects on Infant Anthropometric Measurements in the First 6 Months DOI
Nursan Çınar, Özge Kaya, Seda Tecik

et al.

The Journal of Perinatal & Neonatal Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

The aim of the study is to determine effect macronutrient content breast milk on anthropometric measurements infants in first 6 months. Breast contains essential macro- and micronutrients needed early stages an infant's development. Current literature highlights importance understanding how milk's influences infant growth. protocol has been published PROSPERO (CRD42023425550). This adheres Preferred Reporting Items for Systematic Review Meta-Analysis Protocols (PRISMA-P) guideline. Studies between January 1, 2016, June 2, 2023, were reviewed across databases. Joanna Briggs Institute Cohort checklist was used assess methodological quality. Effect sizes calculated using both fixed-effects random-effects models. Six studies included systematic review meta-analysis. meta-analysis indicated a significant relationship lactose weight gain, length growth, head circumference, as well fat-lipid gain within months (P < .05). No found protein or carbohydrate > findings suggest that concentrations are important determinants Further research with high level evidence standard protocols recommended elucidate relationships

Language: Английский

Citations

0
Breastfeeding after gestational diabetes mellitus: maternal, milk and infant outcomes DOI
Donna T. Geddes, Zoya Gridneva, Sharon L. Perrella

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Purpose of review This examines the complex relationship between gestational diabetes mellitus (GDM) and breastfeeding outcomes, integrating recent evidence on maternal health benefits, milk composition, clinical support strategies. Understanding these relationships is important as GDM affects approximately 14% pregnancies worldwide, with rates continuing to rise alongside increasing obesity age. Recent findings Women who breastfeed for longer periods after show significant improvements in metabolic health, including reduced weight retention better cardiometabolic profiles. While macronutrient content breast appears preserved, differences exist human oligosaccharides fat globule membrane proteins. A previous history predominant shows a 47% reduction abnormal fasting glucose odds subsequent pregnancies. Initial positive indications personalized programs, particularly during pregnancy, are emerging however evaluation comparison current evidence-based interventions yet be carried out. Lifestyle factors known reduce suggests pregnancy may improve outcomes. Summary Despite challenges delayed secretory activation supply women GDM, successful offers substantial benefits. Healthcare providers could implement comprehensive, individualized strategies beginning extending through postpartum period optimize outcomes both mother infant.

Language: Английский

Citations

0
Sampling Procedures for Estimating the Infant Intake of Human Milk Leptin, Adiponectin, Insulin, Glucose, and Total Lipid DOI Open Access
Majed A. Suwaydi, Ching Tat Lai, Zoya Gridneva

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 331 - 331

Published: Jan. 23, 2024

Limited attention is given to the efficacy of protocols for estimation infant intake milk components when investigating their impact on outcomes. We compared actual measured human with estimations derived from 15 determine most reliable approach estimating HM leptin, adiponectin, insulin, glucose, and total lipid. Twenty mothers who were 3–5 months postpartum completed a 24 h profile study pre-/post-feed samples collection. The true (control group) based (MI) was estimated intakes using concentrations five sampling that multiplied by one MI, considered mean MI (800 mL), or global (766 mL). six (three sets pre- post-feed samples, morning (06:00–09:00), afternoon (13:00–16:00), evening (19:00–22:00)) produced accurate estimates these components. Therefore, in absence measurements sampling, protocol comprising three provides

Language: Английский

Citations

2
Effects of Different Thawing and Warming Processes on Human Milk Composition DOI Creative Commons
Lisa F. Stinson, Alexandra D. George, Zoya Gridneva

et al.

Journal of Nutrition, Journal Year: 2023, Volume and Issue: 154(2), P. 314 - 324

Published: Dec. 1, 2023

Language: Английский

Citations

5
Health-Promoting Factors of Human Milk Across Lifespan DOI
Hajar Azraida, Abdelmounaim Baslam, Jawad Laadraoui

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 369 - 389

Published: June 14, 2024

Maternal milk intake during infancy is a fundamental aspect of child nutrition, with significant implications for long-term health outcomes. This chapter explores the importance breastfeeding and nutritional benefits breast optimal growth, immune function, cognitive development in infants. Despite established advantages, various challenges hinder initiation continuation rates, including inadequate support systems cultural barriers. Strategies promoting supporting breastfeeding, such as community education initiatives workplace accommodations, are discussed. By emphasizing critical role maternal intake, this aims to empower stakeholders advocate cornerstone health, ensuring best start life future generations.

Language: Английский

Citations

1
Effect of a prolonged slow expiration technique on 24-h food intake in children hospitalized for moderate bronchiolitis: a randomized controlled trial DOI Creative Commons
Yann Combret,

Margaux Machefert,

Mélody Couet

et al.

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2024, Volume and Issue: 50(1)

Published: Sept. 27, 2024

Language: Английский

Citations

1
Macronutrients in Human Milk and Early Childhood Growth—Is Protein the Main Driver? DOI Open Access
Jie Ma, Debra J. Palmer, Ching Tat Lai

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3514 - 3514

Published: Oct. 16, 2024

Infant growth trajectories reflect current health status and may predict future obesity metabolic diseases. Human milk is tailored to support optimal infant growth. However, nutrient intake rather than composition more accurately predicts outcomes. Although the role of protein leverage in unclear, important for early infancy

Language: Английский

Citations

1