Dietary factors and their influence on immunotherapy strategies in oncology: a comprehensive review

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(4)

Published: April 9, 2024

Abstract Immunotherapy is emerging as a promising avenue in oncology, gaining increasing importance and offering substantial advantages when compared to chemotherapy or radiotherapy. However, the context of immunotherapy, there potential for immune system either support hinder administered treatment. This review encompasses recent pivotal studies that assess influence dietary elements, including vitamins, fatty acids, nutrients, small molecules, patterns, caloric restriction, on ability modulate responses. Furthermore, article underscores how these factors have modify enhance effectiveness anticancer immunotherapy. It emphasizes necessity additional research comprehend underlying mechanisms optimizing efficacy therapy defining strategies may reduce cancer-related morbidity mortality. Persistent investigation this field holds significant promise improving cancer treatment outcomes maximizing benefits

Language: Английский

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Bioactive component integrated textiles: A promising source of medicine and healthcare

Journal of Engineered Fibers and Fabrics, Journal Year: 2025, Volume and Issue: 20

Published: Jan. 1, 2025

The healthcare industry can greatly benefit from natural colorants as bioactive component integrated textiles. These textiles are perfect for use in because they biocompatible, have antimicrobial characteristics and sustainable. It is an exciting new development that might replace harmful synthetic dyes with safer more practical options of bio-colorants makes them both biocompatible antimicrobial. By facilitating quicker healing warding off infections, these further add to improved outcomes. also helps fund research into smart clothes track vital signs better care patients. Incorporating the focus this review paper which will examine different sources fabrication methods. In addition, work discuss obstacles future possibilities bio-colorant technology advancement textile sectors. Developing monitor health parameters, improving wound dressings properties creating fabrics surgical garments hospital linens all potential uses Patients wear protect themselves ultraviolet rays materials could find environmentally friendly medical supplies.

Language: Английский

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Combination of vitamin D and photodynamic therapy enhances immune responses in murine models of squamous cell skin cancer

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 45, P. 103983 - 103983

Published: Jan. 27, 2024

Improved treatment outcomes for non-melanoma skin cancers can be achieved if Vitamin D (Vit D) is used as a neoadjuvant prior to photodynamic therapy (PDT). However, the mechanisms this effect are unclear. Vit elevates protoporphyrin (PpIX) levels within tumor cells, but also exerts immune-modulatory effects. Here, two murine models, UVB-induced actinic keratoses (AK) and human squamous cell carcinoma (A431) xenografts, were analyze time course of local systemic immune responses after PDT ± D. Fluorescence immunohistochemistry tissues flow analysis (FACS) blood employed. In tissue, damage-associated molecular patterns (DAMPs) increased, infiltration neutrophils (Ly6G+), macrophages (F4/80+), dendritic cells (CD11c+) observed. most cases, alone or increased recruitment, + showed even greater recruitment Similarly T total (CD3+), cytotoxic (CD8+) regulatory (FoxP3+) T-cells was observed PDT, increase with combination. FACS revealed variety interesting changes in circulating levels. particular, decreased D, consistent migration into AK lesions. Levels expressing PD-1+ checkpoint receptor reduced AKs following potentially counteracting elevations seen alone. summary, ALA-PDT, treatments individual immunogenic effects, may advantageous combination improve efficacy management dermatology clinic.

Language: Английский

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Melatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review)

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 65(6)

Published: Oct. 22, 2024

Significant advancements have been made in cancer therapy; however, limitations remain with some conventional approaches. Adjuvants are agents used alongside primary treatments to enhance their efficacy and the treatment outcomes of patients. Modern lifestyles contribute deficiencies melatonin vitamin D. Limited sun exposure affects D synthesis, artificial light at night suppresses production. Both possess anti‑inflammatory, immune‑boosting anticancer properties, rendering them potential adjuvants interest. Studies suggest supplementation may address antioxidant imbalances lip, oral pharyngeal cancers. Moreover, promising results from breast, head neck, brain, osteosarcoma research indicate for tumor growth inhibition, improved survival, a better quality life patients cancer. The radioprotective properties another exciting area exploration, potentially enhancing radiotherapy effectiveness while reducing side effects. For its part, sleep‑promoting effects indirectly benefit by influencing immune system. Thus, prevalence highlights importance supplementation, as lower levels can worsen side‑effects treatments. present review explores combining synergistic therapy. These shown promise individually prevention treatment, combined warrant investigation. Therefore, large‑scale controlled trials crucial definitively determine optimal dosage, safety this combination improving lives

Language: Английский

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Vitamin D and viral infections: Infectious diseases, autoimmune diseases, and cancers

Advances in food and nutrition research, Journal Year: 2024, Volume and Issue: unknown, P. 271 - 314

Published: Jan. 1, 2024

Language: Английский

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Vitamin D and Clinical Outcomes in Head and Neck Cancer: A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1100 - 1100

Published: March 21, 2025

Background/Objectives: Vitamin D is classically associated with calcium and phosphate homeostasis, but recent research has expanded its role to include several new roles such as immune regulation, inflammation, potential anti-cancer properties. The vitamin receptor (VDR) expressed in over 400 tissues, including those of the head neck, implying a link between neck cancers (HNCs). Given need for newer better therapeutic approaches, this systematic review aims synthesize existing clinical evidence on relationship status outcomes HNC patients. Methods Results: A comprehensive literature search, across multiple databases PubMed, Google Scholar Science Direct, identified 187,642 studies related cancer, from which 16 met inclusion criteria. criteria were English-language, full-text original (2015-2025) D's progression treatment, focusing human studies. findings indicate that deficiency highly prevalent among patients, rates ranging 47% 95%, particularly advanced-stage undergoing intensive treatment. Inverse association levels risk was reported, higher serum 25(OH)D linked 30-32% reduction cancer risk. Additionally, correlated improved survival reduced recurrence, though some lacked statistical significance. Deficiencies malnutrition postoperative complications, reinforcing nutritional stability surgical recovery. Conclusions: This highlights how common significant (HNC) exploring possible risk, prognosis, survival, treatment-related side effects, malnutrition, post-surgical complications. suggests while are fewer issues, benefits seem level off beyond certain point, indicating more complex relationship. supplementation appears help reduce chemoradiation effects like mucositis, skin toxicity, dysphagia, pain, ultimately improving patients' quality life during

Language: Английский

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Transcriptomic profile induced by calcitriol in CaSki human cervical cancer cell line

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0319812 - e0319812

Published: April 1, 2025

The vitamin D endocrine system, primarily mediated by its main metabolite calcitriol and the receptor (VDR), plays a critical role in numerous human physiological processes, ranging from calcium metabolism to prevention of various tumors, including cervical cancer. In this study, we comprehensively investigated genomic regulatory effects cancer model. We examined transcriptional changes induced CaSki cells, cell line harboring multiple copies HPV16, primary causal agent Our microarray findings, revealed that regulated over 1000 protein-coding genes, exhibiting predominantly repressive effect on transcriptome suppressing twice as many genes it induced. Calcitriol decreased EPHA2 RARA expression while inducing KLK6 CYP4F3 validated qPCR Western blot. Functional analysis demonstrated effectively inhibited key processes involved progression, proliferation migration. This was further supported significant downregulation MMP7 MMP13 mRNA levels. results also showed that, addition significantly regulates non-coding RNAs, altering approximately 400 111 microRNA precursors 29 mature microRNAs, which 17 were upregulated 12 downregulated. Notably, among these calcitriol-regulated microRNAs are some biology, such miR-6129, miR-382, miR-655, miR-211, miR-590, miR-130a, miR-301a, miR-1252. Collectively, findings suggest exhibits antitumor advanced model blocking for tumor underscoring importance maintaining adequate nutritional status.

Language: Английский

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Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1351 - 1351

Published: April 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Language: Английский

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Potential treatment of squamous cell carcinoma by targeting heparin-binding protein 17/fibroblast growth factor-binding protein 1 with vitamin D3 or eldecalcitol

In Vitro Cellular & Developmental Biology - Animal, Journal Year: 2024, Volume and Issue: 60(6), P. 583 - 589

Published: May 7, 2024

Heparin-binding protein 17 (HBp17), first purified in 1991 from the conditioned medium of human A431 squamous cell carcinoma (SCC) line, was later renamed fibroblast growth factor-binding 1 (FGFBP-1). HBp17/FGFBP-1 is specifically expressed and secreted by epithelial cells, it reversibly binds to factor (FGF)-1 FGF-2, as well FGFs-7, -10, -22, indicating a crucial involvement transportation function these FGFs. Our laboratory has investigated reported several studies elucidate SCC cells its potential molecular therapeutic target. transgene exoression A431-4 clonal subline that lacks tumorigenicity does not express HBp17/FGFBP-1, demonstrated significantly enhanced proliferation vitro compared with acquired subcutis nude mice. Knockout (KO) genome editing suppressed tumor growth, motility, control cells. A comprehensive analysis molecules both types revealed promote differentiation were highly KO Additionally, we 1α,25(OH)

Language: Английский

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The protective role of vitamin d in nasopharyngeal carcinoma: insights from Mendelian randomization and meta-analysis

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 9, 2024

In recent years, the anti-tumor effects of vitamin D have garnered increasing attention. However, previous epidemiological studies on relationship between and nasopharyngeal carcinoma (NPC) yielded inconsistent results. This study aims to further explore whether helps reduce risk NPC through Mendelian randomization (MR) meta-analysis.

Language: Английский

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