Kaempferol-induced mitochondrial damage promotes NF-κB- NLRP3-caspase-1 signaling axis-mediated pyroptosis in gastric cancer cells DOI Creative Commons

Xiafei Qi,

Jiatong Liu,

liuxiang Wang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 31, 2023

Abstract Purpose：Gastric cancer （GC）is a gastrointestinal tumor with high morbidity and mortality. Owing to the rate of postoperative recurrence associated GC, effectiveness radiotherapy chemotherapy may be compromised by occurrence severe undesirable side effects. In light these circumstances, kaempferol (KP), flavonoid abundantly present in diverse herbal fruit sources, emerges as promising therapeutic agent inherent anti-tumor properties. This study endeavors demonstrate potential KP context Gastric while unraveling intricate underlying mechanisms. Methods：We employed methods bioinformatics, network pharmacology, molecular docking, followed multiple experimental validations. Result：Our investigations unveil that stimulation effectively promotes activation NLRP3 inflammatory vesicles within AGS cells engaging NF-κB signaling pathway. Consequently, signal cascade triggers cleavage Caspase-1, culminating liberation IL-18. Furthermore, we ascertain facilitate cell pyroptosis inducing mitochondrial damage. Conclusion：Our findings showcase compelling candidate for treatment -related diseases, heralding new possibilities future interventions.

Language: Английский

Multidisciplinary examples of applications: Papers using the MAL-PD/BD/CI/BI theory/method DOI

Ting-Chao Chou

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 181 - 218

Published: Jan. 1, 2024

Language: Английский

Citations

0
Identification of Candidate Hub Genes and Drug Targets for Cholangiocarcinoma via Juhua (Chrysanthemum Morifolium) Bioactivity and Molecular Docking: A Bioinformatics Approach DOI Creative Commons
Yang Song,

Wanliang Sun,

Shuo Zhou

et al.

Cancer Management and Research, Journal Year: 2024, Volume and Issue: Volume 16, P. 1733 - 1746

Published: Dec. 1, 2024

Cholangiocarcinoma (CHOL) is a malignancy with poor clinical outcomes and limited treatment options. While extensive research has investigated genetic signaling pathways in CHOL, the molecular mechanisms underlying disease pathogenesis remain incompletely understood. A key hurdle been lack of systematic, multi-omic approach to illuminate causal relationships between variants CHOL risk.

Language: Английский

Citations

0
Kaempferol-induced mitochondrial damage promotes NF-κB- NLRP3-caspase-1 signaling axis-mediated pyroptosis in gastric cancer cells DOI Creative Commons

Xiafei Qi,

Jiatong Liu,

liuxiang Wang

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 31, 2023

Abstract Purpose：Gastric cancer （GC）is a gastrointestinal tumor with high morbidity and mortality. Owing to the rate of postoperative recurrence associated GC, effectiveness radiotherapy chemotherapy may be compromised by occurrence severe undesirable side effects. In light these circumstances, kaempferol (KP), flavonoid abundantly present in diverse herbal fruit sources, emerges as promising therapeutic agent inherent anti-tumor properties. This study endeavors demonstrate potential KP context Gastric while unraveling intricate underlying mechanisms. Methods：We employed methods bioinformatics, network pharmacology, molecular docking, followed multiple experimental validations. Result：Our investigations unveil that stimulation effectively promotes activation NLRP3 inflammatory vesicles within AGS cells engaging NF-κB signaling pathway. Consequently, signal cascade triggers cleavage Caspase-1, culminating liberation IL-18. Furthermore, we ascertain facilitate cell pyroptosis inducing mitochondrial damage. Conclusion：Our findings showcase compelling candidate for treatment -related diseases, heralding new possibilities future interventions.

Language: Английский

Citations

0