Changes in Hormonal Profile and Body Mass Index in Women with Polycystic Ovary Syndrome After Probiotic Intake: A 12-Week Placebo-Controlled and Randomized Clinical Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 405 - 405

Published: Jan. 23, 2025

Introduction: The beneficial effect of probiotics on the improvement carbohydrate and lipid metabolism, as well body mass index (BMI), has been demonstrated in various patient groups. We aimed to investigate a multi-strain probiotic hormonal balance women with PCOS. Ethical approval was obtained from Bioethical Committee. Methods: study designed 12-week, randomized, double-blind, placebo-controlled clinical study. SanProbi® Barrier capsules, which contain unique composition nine bacteria strains (Lactobacillus Biffidobacterium), were used mean age participants 28.42 ± 5.62 years. A total 50 PCOS, diagnosed based Rotterdam ESHRE criteria, included Among them, 25 randomized placebo group, group. Results: comparison changes individual hormone levels between groups confirmed statistically significant differences for TSH, androstenedione, SHBG, BMI. In case LH, statistical significance difference delta change group use one-tailed test. Conclusions: Probiotic supplementation may serve an alternative supporting treatment, especially phenotype high FAI index. therapy is also effective reducing BMI overweight PCOS

Language: Английский

---

High Fat Diet and Polycystic Ovary Syndrome (PCOS) in Adolescence: An Overview of Nutritional Strategies

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 938 - 938

Published: March 24, 2024

Polycystic ovary syndrome (PCOS) is a multifaceted and heterogeneous disorder, linked with notable reproductive, metabolic, psychological outcomes. During adolescence, key components of PCOS treatment involve weight loss achieved through lifestyle dietary interventions, subsequently pursued by pharmacological or surgical therapies. Nutritional interventions represent the first-line therapeutic approach in adolescents affected PCOS, but different kinds protocols exist, so it necessary to clarify effectiveness benefits most well-known nutritional approaches. We provided comprehensive review current literature concerning definition, pathophysiology, options, highlighting strategies, particularly those related high-fat diets. The proposed literature, such as ketogenic diet (KD), appear provide patients terms control metabolic parameters. Among types KD studies, very low-calorie diets (VLCKD), can be considered an effective intervention for short-term PCOS. It rapidly leads alongside improvements body composition profile. Even though extremely advantageous, long-term adherence limiting factor. Indeed, this regimen could become unsustainable due important restrictions required ketosis development. Thus, combination more nutrient-rich regimens, Mediterranean diet, amplify positive effects individuals

Language: Английский

---

Effectiveness of Probiotics, Prebiotics, and Synbiotics in Managing Insulin Resistance and Hormonal Imbalance in Women with Polycystic Ovary Syndrome (PCOS): A Systematic Review of Randomized Clinical Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3916 - 3916

Published: Nov. 16, 2024

Polycystic ovary syndrome is a common endocrine disorder in women of reproductive age characterized by insulin resistance and hormonal imbalances. Recent research suggests that probiotics synbiotics may improve these parameters modulating the gut microbiota. This study systematically reviewed randomized clinical trials evaluating impact probiotic, prebiotic, synbiotic supplementation on with PCOS.

Language: Английский

---

Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4243 - 4243

Published: July 20, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary syndrome (PCOS) are prevalent conditions that have been correlated with infertility through overlapped pathophysiological mechanisms. MASLD is associated metabolic considered among the major causes of chronic disease, while PCOS, which characterized by ovulatory dysfunction hyperandrogenism, one leading female infertility. The links between PCOS not yet fully elucidated, insulin resistance, hyperandrogenemia, obesity, dyslipidemia being key pathways contribute to lipid accumulation, inflammation, fibrosis, aggravating dysfunction. On other hand, exacerbates resistance dysregulation in women creating a vicious cycle progression. Understanding intricate relationship crucial improving clinical management, collaborative efforts different medical specialties essential optimize fertility health outcomes individuals PCOS. In this review, we summarize complex interplay highlighting importance increasing attention prevention, diagnosis, treatment both entities.

Language: Английский

---

Probiotic Lactobacillus rhamnosus species: considerations for female reproduction and offspring health

Journal of Assisted Reproduction and Genetics, Journal Year: 2024, Volume and Issue: 41(10), P. 2585 - 2605

Published: Aug. 22, 2024

Language: Английский

---

Unraveling Immune Regulatory Mechanisms in PCOS

NTU Journal of Pure Sciences, Journal Year: 2025, Volume and Issue: 3(4)

Published: Jan. 1, 2025

Abstract. The etiology of polycystic ovary syndrome (PCOS) is complex and includes both endocrine in addition to immunological abnormalities. PCOS a condition that involves chronic low-grade inflammation, which the pathological state regulation pro-inflammatory factors release rate dysfunctioning endotheliocytes accumulation leukocytes. In PCOS, particular, immune cells regulatory molecules participate significantly maintain metabolic homeostasis modulate reactions. People with may have hormonal changes such as low levels progesterone because it usually occurs irregularly or stops ovulated turn overstimulation system results from autoantibodies production. addition, dysfunction cytokines imbalance are associated insulin resistance, hyperandrogenism obesity PCOS. also causes immunity create an inflammatory aura. Autoimmune diseases patients be developed due imbalances. There been studies indicating connection, between underlying It appears grade inflammation strongly can contribute loss ovulation. Additionally there seems ovarian cytokines, disrupt functions lead excessive production androgens increase resistance through various mechanisms. article aims shed light on role disturbance disease, including its emergence development. This deeper understanding mechanism help finding new therapeutic targets reduce severity disease poor fertility women suffered

Language: Английский

---

Hotspots and research trends of gut microbiome in polycystic ovary syndrome: a bibliometric analysis (2012–2023)

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Polycystic ovary syndrome (PCOS) is a common gynecological condition affecting individuals of reproductive age and linked to the gut microbiome. This study aimed identify hotspots research trends within domain microbiome in PCOS through bibliometric analysis. Utilizing techniques, we examined literature on from Web Science Core Collection spanning period 2012 2023. Analytical tools such as CiteSpace, VOSviewer, Bibliometric R packages were employed evaluate various metrics, including countries/regions, institutions, authors, co-cited authors' H-index, journals, co-references, keywords. A total 191 publications identified field PCOS, with an increase annual 2018 People's Republic China was most productive country, followed by United States America (USA), India. Shanghai Jiao Tong University, Fudan Beijing University Chinese Medicine top three institutions. Thackray VG prolific author, holding highest while Liu received number citations. The journal "Frontiers Endocrinology" published articles this domain. frequently reference authored Qi XY. analysis keyword burst detection "bile acids" (2021-2023) leading frontier keyword. Additionally, "gut dysbiosis," "phenotypes," "adolescents," "metabolomics," "metabolites," "fecal microbiota transplantation," "IL-22" have emerged primary keywords reflecting recent trends. explores how influences endocrine metabolic disorders related emphasizing its role development treatments targeting findings serve valuable resource for researchers, enabling them critical emerging areas investigation field.

Language: Английский

---

Comparison of the impact of intermittent fasting diet alone or in conjunction with probiotic supplementation versus calorie-restricted diet on inflammatory, oxidative stress, and antioxidant capacity biomarkers in women with polycystic ovary syndrome: A randomized placebo-controlled trial

Journal of Research in Medical Sciences, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 1, 2025

Background: The objective of this study was to compare the effects early time-restricted eating (eTRE) and eTRE plus probiotic supplementation daily caloric restriction (DCR) alone in terms biomarkers oxidative stress (OS), antioxidant capacity, inflammation, blood pressure (BP) obese women with polycystic ovary syndrome (PCOS). Materials Methods: research conducted as a randomized, parallel, placebo-controlled clinical trial an 8-week follow-up period. Participants were randomly assigned one three groups: 14:10 ( n = 30), placebo or DCR 30). At beginning 8 weeks intervention, systolic (SBP) diastolic BP, OS parameters evaluated. Results: A total 90 participants (mean age, 30.49 years mean weight, 81.45 kg) enrolled trial. After we observed SBP significantly decreased both + group (−0.31 mmHg [95% confidence interval (CI): −0.55, −0.07]) (−0.24 CI: −0.43, 0.04]), no significant differences between groups. Moreover, C-reactive protein (CRP) levels reduced all groups P < 0.005). Total capacity (TAC) also showed notable improvement 0.012) 0.032). However, there regarding OS, TAC, CRP markers. Conclusion: It not found that probiotics intervention resulted improving inflammatory, than standard diet among PCOS. present did reveal improvements inflammatory markers, either combined compared diagnosed Trial Register no: IRCT20121110011421N5.

Language: Английский

---

Polycystic Ovary Syndrome and Sex Hormones in Bariatric Surgery Candidates

Obesity Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

---

Elevated IGFBP7 expression in follicular granulosa cells promotes PCOS pathogenesis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167743 - 167743

Published: Feb. 1, 2025

Language: Английский

---