Data & Metadata,
Journal Year:
2024,
Volume and Issue:
3
Published: Dec. 4, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
complex
endocrine
and
metabolic
condition
that
significantly
affects
the
fertility
of
women
reproductive
age.
The
aim
study
was
to
analyze
polycystic
its
impact
on
infertility
through
PRISMA
2020
literature
review.
A
systematic
search
conducted
in
PubMed
using
MeSH
terms
related
PCOS
infertility,
covering
publications
from
2018
2024.
Original
articles,
reviews,
relevant
meta-analyses
were
included,
while
duplicate
studies
or
those
with
insufficient
methodological
quality
excluded.
results
showed
hyperandrogenism,
insulin
resistance,
chronic
inflammation
are
key
mechanisms
affecting
ovulation
endometrial
quality,
contributing
infertility.
Lifestyle
modifications,
such
as
diet
exercise,
identified
first
line
treatment,
emerging
therapies
like
resveratrol,
probiotics,
traditional
Chinese
medicine
offer
promising
options.
Additionally,
relationships
between
comorbidities
thyroid
diseases
osteoporosis
observed,
expanding
systemic
impact.
Despite
advances
pathophysiological
understanding,
challenges
persist
due
lack
classification
genotypes
clinical
phenotypes.
It
concluded
management
should
be
comprehensive
personalized,
integrating
innovative
multidisciplinary
strategies
improve
patients'
life
outcomes.
This
provides
solid
foundation
guide
future
research
optimize
practice
Children,
Journal Year:
2023,
Volume and Issue:
10(12), P. 1872 - 1872
Published: Nov. 29, 2023
Polycystic
ovary
syndrome
(PCOS)
is
a
common
endocrine
disorder
that
affects
women
of
reproductive
age
and
female
adolescents.
The
diagnosis
PCOS
difficult
during
puberty
due
to
overlapping
the
criteria
with
normal
variations
menstruation
this
period.
There
are
insufficient
data
on
gut
microbiome
potential
mechanisms
linking
two.
present
systematic
review
aimed
detect
dysbiosis
patterns
in
youth
PCOS,
compared
healthy
controls.One
hundred
seventy-eight
studies
were
identified
by
databases
search
sixty-eight
full-text
assessment
for
eligibility;
four
included
underwent
quality
control.The
results
study
controversial
accordance
findings
from
literature.
A
change
α
diversity
was
found
adolescents,
no
significant
alterations
β
diversity.
Almost
all
Firmicutes,
Bacteroidetes,
Actinobacteria
abundance
both
groups,
changes
family
composition
fluctuations
at
phylum
level.
statistically
association
between
these
clinical
or
biochemical
features
described.This
confirmed
microbiota
PCOS.
However,
further
needed
clarify
build
strategy
prevent
syndrome.
Journal of Education Health and Sport,
Journal Year:
2024,
Volume and Issue:
59, P. 166 - 182
Published: Feb. 14, 2024
Introduction
Polycystic
ovary
syndrome
(PCOS),
first
described
by
Stein
and
Leventhal
in
1935,
is
one
of
the
most
prevalent
endocrine
system
conditions
affecting
women
reproductive
age.
It
affects
between
6%
13%
majority
cases
are
identified
ages
20
30.
Unfortunately,
disease
usually
diagnosed
only
when
bothersome
symptoms
such
as
hair
loss,
alopecia,
acne,
infertility-related
problems
occur.
Based
on
Rotterdam
criteria,
four
phenotypes
PCOS
distinguished.
Aim
study
This
review
aims
to
present
current
state
knowledge
about
possible
treatment
approaches,
both
non-pharmacological
pharmacological.
Materials
methods
The
paper
was
created
based
Pubmed
database.
literature
reviewed
using
keywords:
”PCOS”,
”PCOS
treatment”
“
medications
“.
knowledge
Treatments
for
must
be
tailored
specific
needs
each
patient.
In
management
PCOS,
special
attention
paid
diet,
physical
activity,
restoration
Gut
Microbiome.
Medications
used
therapy
oral
contraceptives
anti-androgens,
insulin
sensitizers,
ovulation
inducers,
calcium
vitamin
D
supplements,
statins,
Glucagon-like-peptide-1
(GLP-1)
agonists,
inositols
interleukin
22
(IL-22)
therapy.
Summary
Treatment
options
menstrual
irregularities
hirsutism
clinical
goals
preferences
ideal
would
causal
treatment,
but
due
ongoing
lack
full
understanding
pathogenesis
syndrome,
not
entirely
feasible.
important
a
multimodal
approach
treat
comorbid
diabetes
mellitus
type
2,
obesity,
hyperlipidemia,
depression,
infertility.
Data & Metadata,
Journal Year:
2024,
Volume and Issue:
3
Published: Dec. 4, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
complex
endocrine
and
metabolic
condition
that
significantly
affects
the
fertility
of
women
reproductive
age.
The
aim
study
was
to
analyze
polycystic
its
impact
on
infertility
through
PRISMA
2020
literature
review.
A
systematic
search
conducted
in
PubMed
using
MeSH
terms
related
PCOS
infertility,
covering
publications
from
2018
2024.
Original
articles,
reviews,
relevant
meta-analyses
were
included,
while
duplicate
studies
or
those
with
insufficient
methodological
quality
excluded.
results
showed
hyperandrogenism,
insulin
resistance,
chronic
inflammation
are
key
mechanisms
affecting
ovulation
endometrial
quality,
contributing
infertility.
Lifestyle
modifications,
such
as
diet
exercise,
identified
first
line
treatment,
emerging
therapies
like
resveratrol,
probiotics,
traditional
Chinese
medicine
offer
promising
options.
Additionally,
relationships
between
comorbidities
thyroid
diseases
osteoporosis
observed,
expanding
systemic
impact.
Despite
advances
pathophysiological
understanding,
challenges
persist
due
lack
classification
genotypes
clinical
phenotypes.
It
concluded
management
should
be
comprehensive
personalized,
integrating
innovative
multidisciplinary
strategies
improve
patients'
life
outcomes.
This
provides
solid
foundation
guide
future
research
optimize
practice
