Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 32(1), P. 249 - 271

Published: Nov. 13, 2023

Abstract Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose this study was evaluate clinical efficacy vitamin D (VD) in COVID-19 long COVID-19, explain discrepancy outcomes highlight potential impact metformin on VD recent articles. Articles January 2022 August 2023 were selected for review. objective achieved by reviewing, analyzing, discussing articles demonstrating (1) mechanism action (2) observational or randomized trials (RCTs) that support not beneficial effects COVID. (3) genetic non-genetic reasons variation VD. collected electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, Cochrane Database Systematic Reviews. Twenty three studies conducted vitro animal models indicated may act through protecting respiratory system antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate adaptive immune functions up regulation autophagy gene activity. Our review identified 58 met criteria. number publications supporting a activity treating 49 (86%), including 12 meta-analyses. Although total patients included all 14,071,273, role 14,029,411 (99.7%). Collectively, extensive decisive relationship between low levels severity mortality outcomes. Importantly, evidence intervention has demonstrated effectiveness supplements COVID-19. Furthermore, results 4 supported alleviating symptoms disease. However, eight RCTs one meta-analysis contain low-grade against Twenty-five have addressed association VDR DBP polymorphisms treatment failure Impaired signaling underlie variability mechanisms. Interestingly, studies, therapeutic possibly improving AMPK enhancing In conclusion, been significantly strengthened over past 18 months, with several meta-analyses reporting conclusive supplementation highlighting improve sensitivity

Language: Английский

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A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 634 - 634

Published: Feb. 11, 2025

Background: Vitamin D (VD) supplementation has increased considerably in the last decade, whether for prevention or treatment of numerous diseases, including bone, cardiovascular, endocrine, neurologic, psychological, respiratory, infectious, oncological. The primary objective this scoping review was to examine and synthesize scientific evidence on role VD all-type cancer patients undergoing adjuvant neoadjuvant therapy with chemotherapy (CT) radiotherapy (RT), namely improving side effects. Methods: This conducted by selecting papers from CINAHL, Scopus PubMed databases based descriptor terms mesh title/abstract, taking into consideration defined inclusion exclusion criteria, following PRISMA-ScR (PRISMA extension reviews) statement. Results: A total 758 were identified different during review. However, using only five publications made up final sample study. studies included heterogeneous study methodologies, objectives, diagnosis, as well methods assess body composition, which makes it difficult compare them. Based analyzed studies, associations found between bone density who underwent preoperative chemoradiotherapy (CRT). In non-small-cell lung receiving CT, some effects associated attenuated reduced. addition, another that deficiency (VDD) been peripheral neuropathy (PN) induced CT breast cancer. be safe effective. Conclusions: review, is highlighted a crucial factor preventing RT treating other treatment-related health conditions, such osteoporosis, ameliorating (nausea, vomiting, fatigue) aggressive RT.

Language: Английский

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Vitamin D supplementation for managing COVID-19 in patients with vitamin D deficiency: a systematic review and meta-analysis of randomised controlled trials

BMJ Open, Journal Year: 2025, Volume and Issue: 15(3), P. e091903 - e091903

Published: March 1, 2025

Objectives Vitamin D deficiency is prevalent among the population. Previous studies have shown that vitamin supplementation might be useful for treating COVID-19 infection. Therefore, we performed a meta-analysis to explore efficacy in patients with deficiency. Design Systematic review and Data sources PubMed, Cochrane Library, Embase Web of Science. Eligibility criteria Randomised controlled trials exploring extraction synthesis Two independent reviewers employed standardised methods search, screen code included studies. The primary outcomes mortality during follow-up, 28-day mortality, need mechanical ventilation intensive care unit (ICU). secondary outcome length stay hospital ICU. risk bias was assessed using Risk Bias 2 tool. Depending on level heterogeneity, either random-effects model or fixed-effects applied. findings were summarised Grading Recommendations Assessment, Development Evaluation (GRADE) evidence profiles synthesised qualitatively. Results A total nine studies, comprising 870 participants, analysis. pooled results indicated associated lower (risk ratio 0.76; 95% CI 0.60 0.97). However, this apparent benefit not robust when examined through leave-one-out method trial sequential Regarding other outcomes, there no statistically significant difference between terms ICU admission. 0.41 day shorter (mean −0.41; −1.09 0.28) 0.07 −0.07; −0.61 0.46) compared supplementation; however, neither significant. Conclusion Based low moderate quality, reduced rate follow-up it did improve nor reduce admission, hospital. PROSPERO registration number CRD42024573791.

Language: Английский

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Calcifediol or Corticosteroids in the Treatment of COVID-19: An Observational Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1910 - 1910

Published: June 17, 2024

Medical treatment of coronavirus 19 disease (COVID-19) is a therapeutic challenge. The available data strongly suggest that calcifediol may reduce the severity COVID-19, and corticosteroids are choice worldwide for severe COVID-19. Both have very similar action profile, their combined use in patients modify contribution each administered compound. Objective: To evaluate how with and/or medical practice modified need ICU admission, death, or poor prognosis hospitalized COVID-19 during first outbreaks. Design, setting: A retrospective observational cohort study admitted to Pneumology Unit Hospital Universitario Reina Sofía (Córdoba, Spain). Interventions: Patients were treated or/and best therapy standard care, according clinical guidelines. Measurements: Admission intensive care unit (ICU) death hospitalization prognosis. Results: Seven hundred twenty-eight included. According received, they included four groups: (n = 68), glucocorticoids 112), both 510), neither 38). Of 578 calcifediol, 88 (15%), while 150 not 39 required admission (26%) (p < 0.01). Among taking without glucocorticoids, only 4 68 (5.8%) compared 84 510 (16.5%) 0.022). 595 who had good prognosis, 568 (82.01%) received versus 133 whom 90 (67.66%) 0.001). This difference was found corticosteroids. Interpretation: moderate mild could be administering corticosteroids, until natural history reaches stage hyperinflammation.

Language: Английский

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Vitamin D deficiency and the need to replenish it in COVID-19

Sanitarnyj vrač (Sanitary Doctor), Journal Year: 2024, Volume and Issue: 10, P. 710 - 725

Published: Sept. 30, 2024

More than five years have passed since the beginning of COVID-19 pandemic, but although fundamental role vitamin D’s effect on immune system is quite obvious to vast majority specialists, there are publications expressing a sharply negative attitude towards use D preparations for treatment patients infected with SARSCoV- 2. The purpose work: «generalization international experience issue deficiency in and need replenish it.» From archive National Library Medicine USA, containing 15,768 full versions articles incidence coronavirus population, we selected 49 presenting results clinical confirmed diagnosis COVID-19. Of these, 38 studies involving more 3,800 SARS-CoV-2 showed positive using as therapeutic agent (improvement inflammation markers, reduction artificial ventilation, length stay clinic, hospital mortality). In three articles, authors conclude that ineffective, they contain information about usefulness such use, differences intervention groups control not statistically significant. Seven indicate zero from preparations, one article says taking worsened condition critically ill patients. ratio positive, insignificant, trials (38:3:7:1) It significantly biased supplements reduce severity disease mortality infection. most common type drug used therapy cholecalciferol, calcidiol less often used, calcitriol ergocalciferol even (isolated cases been described). To date, has demonstrated greatest effectiveness complex COVID -19.

Language: Английский

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The Effect of Vitamin D on Metabolic Bone Disease and Chronic Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(22), P. 4775 - 4775

Published: Nov. 14, 2023

The history of vitamin D begins more than 100 years ago, with the initial documentation rickets in industrialized cities England [...].

Language: Английский

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