This
study
aimed
to
investigate
the
effect
of
potassium
poly-γ-glutamate
(PGA-K)
on
mice
fed
a
high-fat
diet
consisting
60%
total
calories
for
duration
12
weeks.
PGA-K
administration
reduced
increase
in
body
weight,
epididymal
fat,
and
liver
weight
caused
by
compared
obese
group.
The
triglyceride,
low-density
lipoprotein
cholesterol
high-density
levels,
which
are
blood
lipid
indicators,
were
significantly
increased
group
but
decreased
PGA-K-treated
resulted
significant
inhibition
pro-inflammatory
cytokines,
including
tumor
necrosis
factor
α
interleukin
6.
Moreover,
levels
leptin
insulin,
insulin
resistance
These
results
suggest
that
exhibits
protective
against
obesity
induced
diet,
underscoring
its
potential
as
candidate
treatment.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
176, P. 116762 - 116762
Published: May 23, 2024
Obesity
is
a
multifaceted
medical
condition
characterized
by
the
pathological
accumulation
of
excessive
lipids
in
body.
We
investigated
effects
morroniside,
bioactive
compound
derived
from
Cornus
officinalis,
on
adipogenesis.
used
preadipocyte
3T3-L1
stable
cell
line
and
primary
cultured
adipose-derived
stem
cells
(ADSCs)
vitro
ovariectomized
(OVX)
high-fat
diet
(HFD)-fed
obese
mouse
model
vivo.
Preadipocyte
ADSCs
incubated
with
morroniside
during
adipocyte
differentiation
mice
subjected
to
OVX
HFD
received
oral
treatment
for
12
weeks.
Morroniside
significantly
reduced
fatty
acid
downregulated
adipogenesis-related
gene
expression,
concomitant
decrease
triglyceride
content
an
increase
glycerol
release
cells.
The
results
vivo
study
showed
that
ameliorated
obesity-related
phenotypes
reducing
body
weight
gain,
hepatic
steatosis,
adipose
tissue
mice.
These
findings
suggest
promising
preventing
treating
obesity.
Precision Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
7(3)
Published: July 24, 2024
Abstract
Type
2
diabetes
mellitus
(T2DM)
is
a
metabolic
disease
that
characterized
by
chronic
hyperglycaemia.
MicroRNAs
(miRNAs)
are
single-stranded,
small
non-coding
RNAs
play
important
roles
in
post-transcriptional
gene
regulation.
They
negative
regulators
of
their
target
messenger
(mRNAs),
which
they
bind
either
to
inhibit
mRNA
translation,
or
induce
decay.
Similar
proteins,
miRNAs
exist
different
isoforms
(isomiRs).
and
isomiRs
selectively
loaded
into
extracellular
vesicles,
such
as
the
exosomes,
protect
them
from
RNase
degradation.
In
T2DM,
exosomal
produced
cell
types
transported
among
primary
sites
insulin
action.
These
interorgan
crosstalk
regulate
various
T2DM-associated
pathways
adipocyte
inflammation,
signalling,
β
cells
dysfunction
many
others.
this
review,
we
first
focus
on
mechanism
exosome
biogenesis,
followed
miRNA
biogenesis
isomiR
formation.
Next,
discuss
development
T2DM
provide
evidence
clinical
studies
support
potential
biomarkers.
Lastly,
highlight
use
personalized
medicine,
well
addressing
current
challenges
future
opportunities
field.
This
review
summarizes
how
research
has
developed
very
basic
applications,
with
goal
advancing
towards
era
medicine.
Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(11), P. 1602 - 1602
Published: Nov. 13, 2023
The
etiology
of
metabolic
disorders,
such
as
obesity,
has
been
predominantly
associated
with
the
gut
microbiota,
which
is
acknowledged
an
endocrine
organ
that
plays
a
crucial
role
in
modulating
energy
homeostasis
and
host
immune
responses.
presence
dysbiosis
potential
to
impact
functioning
intestinal
barrier
gut-associated
lymphoid
tissues
by
allowing
transit
bacterial
structural
components,
lipopolysaccharides.
This,
turn,
may
trigger
inflammatory
pathways
potentially
lead
onset
insulin
resistance.
Moreover,
modify
production
gastrointestinal
peptides
are
linked
feeling
fullness,
hence
leading
increase
food
consumption.
In
this
literature
review,
we
discuss
current
developments,
microbiota
on
lipid
metabolism
well
processes
its
changes
led
development
disorders.
Several
methods
have
developed
could
be
used
undo
abnormalities.
Methods:
After
researching
different
databases,
examined
PubMed
collection
articles
conducted
review.
Results:
applying
our
exclusion
inclusion
criteria,
initial
search
yielded
1345
articles.
We
further
various
filters
narrow
down
titles
analysis
and,
specific
study,
selected
final
ten
studies,
results
included
Results
section.
Conclusions:
Through
integrity,
resistance,
other
influencing
factors,
impacts
host’s
obesity.
Although
area
relationship
obesity
still
stages
research,
it
offers
great
promise
for
developing
new
therapeutic
targets
help
prevent
cure
restoring
healthy
condition.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2209 - 2209
Published: Sept. 27, 2024
The
high
prevalence
of
diabetes
mellitus
(DM)
poses
a
significant
public
health
challenge,
with
diabetic
kidney
disease
(DKD)
as
one
its
most
serious
consequences.
It
has
become
increasingly
clear
that
type
2
DM
(T2D)
and
the
complications
DKD
are
not
purely
metabolic
disorders.
This
review
outlines
emerging
evidence
related
to
step-by-step
contribution
macrophages
development
progression
in
individuals
who
specifically
develop
T2D
result
obesity.
macrophage
is
prominent
inflammatory
cell
contributes
obesity,
where
adipocyte
hypertrophy
leads
recruitment
eventually
expansion
adipose
tissue.
recruited
secrete
proinflammatory
cytokines,
which
cause
systemic
inflammation,
glucose
dysregulation,
insulin
sensitivity,
ultimately
contributing
T2D.
Under
such
pathological
changes,
susceptible
elevated
thereby
activates
signaling
pathways
drive
monocyte
recruitment.
In
particular,
early
produces
cytokines/chemokines
contribute
inflammation
tissue
damage
associated
pathology.
Macrophage
activation
crucial
inciting
factors
also
persist
progresses.
Thus,
targeting
function
could
be
promising
therapeutic
approach,
potentially
offering
benefits
for
managing
at
all
stages
progression.
This
study
aimed
to
investigate
the
effect
of
potassium
poly-γ-glutamate
(PGA-K)
on
mice
fed
a
high-fat
diet
consisting
60%
total
calories
for
duration
12
weeks.
PGA-K
administration
reduced
increase
in
body
weight,
epididymal
fat,
and
liver
weight
caused
by
compared
obese
group.
The
triglyceride,
low-density
lipoprotein
cholesterol
high-density
levels,
which
are
blood
lipid
indicators,
were
significantly
increased
group
but
decreased
PGA-K-treated
resulted
significant
inhibition
pro-inflammatory
cytokines,
including
tumor
necrosis
factor
α
interleukin
6.
Moreover,
levels
leptin
insulin,
insulin
resistance
These
results
suggest
that
exhibits
protective
against
obesity
induced
diet,
underscoring
its
potential
as
candidate
treatment.
