Antibiofilm, Antimicrobial, Anti-Quorum Sensing, and Antioxidant Activities of Saudi Sidr Honey: In Vitro and Molecular Docking Studies

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2177 - 2177

Published: Aug. 22, 2023

Sidr honey is a valuable source of bioactive compounds with promising biological properties. In the present study, antimicrobial, antioxidant, and anti-quorum sensing properties Saudi were assessed, along phytochemical analysis, via gas chromatography–mass spectrometry (GC-MS). silico study was also carried out to drug-likeness identified their affinity known target proteins assessed using molecular docking approach. The results showed that exhibited antibacterial activity, MIC values ranging from 50 400 mg/mL MBC >450 mg/mL. Interestingly, active against Candida auris neoformans, an value about 500 Moreover, important antioxidant activities (ABTS assay: IC50 5.41 ± 0.045 mg/mL; DPPH 7.70 0.065 mg/mL) β-carotene bleaching test (IC50 ≥ 20 mg/mL). addition, able inhibit biofilm formation on glass slides at 1/2 by 77.11% for Bacillus subtilis, 70.88% Staphylococcus aureus, 61.79% Escherichia coli, 56.64% Pseudomonas aeruginosa. Similarly, violacein production Chromobacterium violaceum reduced 56.63%, while pyocyanin P. aeruginosa decreased 46.27% low concentration honey. ADMET five compounds, namely, 1-cyclohexylimidazolidin-2-one, 3-Butyl-3-methylcyclohexanone, 4-butyl-3-methoxy-2-cyclo penten-1-one, 2,2,3,3-Tetramethyl cyclopropane carboxylic acid, 3,5-dihydroxy-2-(3-methylbut-2-en-1-yl compound highest binding energy antimicrobial (1JIJ, 2VAM, 6B8A, 6F86, 2CDU, 1OG5). Overall, obtained highlighted potential as rich can be used food preservatives molecules.

Language: Английский

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Understanding the Anticancer Properties of Honey

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11724 - 11724

Published: Oct. 31, 2024

Uncontrolled cell growth that possesses the capacity to exhibit malignant behavior is referred as cancer. The cytotoxic drugs used fight cancer are associated with several adverse effects and not always readily available or affordable, especially in developing countries. These issues addition shortcomings of current treatment regimen. According growing research, honey normal cells but highly particularly tumor cells, suggesting may display anticancer effects. Research has shown affects a number signaling pathways; however, at moment, precise method completely known.

Language: Английский

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Unlocking the Healing Potential: A Comprehensive Review of Ecology and Biology of Medical‐Grade Honey in Wound Management and Tissue Regeneration

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 1, 2025

Honey has long been studied for its healing abilities in wound care. This narrative review examines properties and their impact on healing, particularly ability to accelerate closure promote tissue regeneration. The focuses how honey's botanical origins affect medical wound-healing capabilities. Finally, clinical studies effectiveness were reviewed compared traditional treatments. Relevant keywords searched databases, yielding 1250 documents. After excluding nonrelevant sources, 450 documents refined, 167 articles selected based thematic alignment originality. Data extraction focused study design, intervention details, outcomes, with quality assessed using standardized criteria. adhered CONSORT SANRA guidelines ensure methodological rigor reporting transparency. Honey-based products have demonstrated significant antibacterial, anti-inflammatory, tissue-regenerative properties, making them highly effective improving chronic burn wounds. These also shown reduce infection rates hospital stays. While some reported positive outcomes accelerating the process, others found no difference conventional Medical-grade honey (MGH) holds potential care due versatility, though variations composition present challenges. Further research is needed optimize use. of MGH remains debated, mixed results from trials. Genetic modification bees enhance MGH's could make it more competitive against medications costs, improve energy efficiency, minimal side effects. Rigorous necessary determine optimal use fully unlock potential, which revolutionize management globally.

Language: Английский

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Therapeutic Effects of Nanocoating of Apitoxin (Bee Venom) and Polyvinyl Alcohol Supplemented with Zinc Oxide Nanoparticles

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 172 - 172

Published: Jan. 28, 2025

Background/Objectives: Bee venom (BV), as a natural product, is one of the foundations pharmaceutical industry, through which many diseases, including serious ones, can be effectively treated. The BV nanofilm an effective antidote delivered into human body to target affected area and address issue without major side effects. In this study, we investigated intriguing therapeutic effects apitoxin (bee venom) used in isolation, combined with powerful properties zinc oxide nanoparticles. Methods Results: was evaluated using Fourier transform infrared (FTIR) spectroscopy X-ray diffraction (XRD). extract analyzed mass spectrometry (MS), identified 84 active components present at varying concentrations. treated both polyvinyl alcohol (PVA) nanoparticles (ZNPs) increase intensity OH CH2 groups enhance dispersion C=O. has demonstrated anti-type 2 diabetes activity by inhibiting α-amylase α-glucosidase, are starch-degrading enzymes. mixture BV, PVA, ZNPs, exhibited highest antidiabetic IC50 values 30.33 μg/mL 5.55 for inhibition compared 51.69 µg/mL 7.30 respectively. also showed higher anti-inflammatory red blood cell (RBC) hemolysis, 16.99 comparison 72.99 alone. broad-spectrum antimicrobial activity, targeting Gram-positive (Staphylococcus aureus ATCC 6538 Bacillus subtilis 6633) Gram-negative bacteria (Salmonella typhi 6539, Escherichia coli 8739). Furthermore, increased antioxidant recorded 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging effect 4.26 19.43 found more toxic liver tissue (HepG2 line) than nanofilm, 18.5 ± 0.08 52.27 0.7 μg/mL, displayed toxicity (2.3%) 97.7% viability 250 0.09% 99.9% same concentration. Conclusions: emerges promising alternative medicine, offering innovative solution treating various diseases its high concentration therapeutically compounds effortless delivery.

Language: Английский

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The effect of multifloral honey on cytotoxicity and the mitochondrial apoptotic pathway in ovarian cancer cell

Mediterranean Journal of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Background Ovarian cancer is one of the most common malignancies in female reproductive system. Honey has a range medical properties. It been shown to have anticancer properties, especially for breast, cervical, etc. cancers. Objective In our study, we aimed investigate cytotoxic, anti-migratory, and mitochondrial apoptotic pathway effects Multifloral honey on Adenocarcinoma SKOV3 cell line. Methods The MTT assay was used evaluate anti-proliferative effect HDF lines. Subsequently, differences expression genes involved apoptosis were examined using RT-qPCR Western Blot methods. Finally, migration observed under microscope. Results found that did not exhibit cytotoxic cell, but significantly suppressed proliferation, promoting apoptosis. study cells, significant decrease ratio Bax/Bcl-2 (P = 0.0043) method, while expressions Cyt-C Bad increased 0.0034 P < 0.0001, respectively). analysis confirmed ratio. wound healing results, inhibited cell. Conclusion Our results provide preliminary evidence induces death line through involvement intrinsic pathways, it demonstrates activity against human ovarian lines first time.

Language: Английский

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Review on role of honey in disease prevention and treatment through modulation of biological activities

Open Life Sciences, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Honey has been used for centuries due to its health-promoting properties. and bioactive compounds regulate oxidative stress, inflammation, other biological activities, making it a promising natural remedy. Its role as anti-diabetic, wound healing, cardioprotective, anti-microbial, hepatoprotective potential proven through in vitro vivo studies. Moreover, disease management reported the inhibition of pro-inflammatory enzymes downregulation cytokine expression secretion. Besides, exerts modulatory actions on various signaling pathways such nuclear factor-κB, tumor suppressor genes, apoptosis, angiogenesis, MAPK pathway. The main aim this review is present wide-ranging overview current evidence regarding impact honey pathogenic conditions. However, further research based animal models clinical trials required fully understand mechanisms action safety diseases. There limited data action. comprehensive studies are needed investigate health benefits honey, including efficacies, safety, bioavailability, underlying

Language: Английский

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Quantitative analysis of biochemical characteristics and anti-cancer properties in MCF-7 breast cancer cell line: a comparative study between Ziziphus jujube honey and commercial honey

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Feb. 24, 2024

Language: Английский

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Antibacterial Activity and Prebiotic Properties of Six Types of Lamiaceae Honey

Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 868 - 868

Published: Sept. 10, 2024

Our work investigated the antimicrobial and prebiotic properties of basil, mint, oregano, rosemary, savory, thyme honey. The potential action, assessed against pathogens

Language: Английский

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Chitosan nanoparticles of imatinib mesylate coated with TPGS for the treatment of colon cancer: In-vivo & in-vitro studies

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122935 - 122935

Published: Nov. 4, 2024

Language: Английский

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Honeybees and the One Health Approach

Environments, Journal Year: 2024, Volume and Issue: 11(8), P. 161 - 161

Published: July 26, 2024

The One Health approach recognizes the interconnectedness between human, animal, and environmental health. Honeybees (Apis mellifera) embody this framework due to their crucial role in ecosystems, food production, susceptibility contaminants. Despite suitability for a approach, there is lack of research showcasing multidisciplinary impacts contributions bees. objective work explore application bees through narrative review. This highlights contribution history culture, economy, medicine, nutrition, security, functioning ecosystems. It also demonstrates that bee health affected by land management, agricultural practices, contaminants, nutritional resource availability, predators diseases, weather, climate patterns, beekeeping practices. complex system highly influenced policy which will benefit animal directly human indirectly. Thus, protection should be prioritized.

Language: Английский

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