Vitamin D and thyroid function of pregnant women in a sunny region: is there any connection?
Revista da Associação Médica Brasileira,
Journal Year:
2025,
Volume and Issue:
71(2)
Published: Jan. 1, 2025
SUMMARY
OBJECTIVE:
The
aim
of
this
study
was
to
investigate
the
relationship
between
vitamin
D
serum
concentrations
and
thyroid
hormones
pregnant
women
living
in
a
sunny
region
Northeast
Brazil.
METHODS:
This
is
cross-sectional
secondary
analysis
that
evaluated
iodine
status
attending
prenatal
consultations
tertiary
hospital.
Consecutive
patients
(>18
years)
were
conveniently
sampled.
Blood
samples
collected
for
study,
including
measurements
D,
anti-TPO,
anti-Tg
antibodies,
thyroid-stimulating
hormone,
total
free
thyroxine
(TT4,
FT4),
triiodothyronine
(TT3,
FT3).
Vitamin
levels
<20
ng/mL
considered
deficient.
Between
20
30
classified
as
insufficient,
>30
sufficient.
Additional
data
on
urinary
concentrations,
anthropometry,
sociodemographic,
gestational
features
also
collected.
RESULTS:
A
562
included,
with
median
age
29
years.
Most
them
(47.9%)
first
semesters.
Only
3.9%
subjects
presented
deficiency,
while
81%
had
insufficient
values
15.1%
sufficient
levels.
not
significantly
correlated
or
associated
body
mass
index
(all
p-values
>0.05).
CONCLUSION:
Our
adds
growing
evidence
highlighting
importance
assessing
both
population-
region-specific
contexts,
it
may
vary
accordingly.
Language: Английский
Vitamin D concentration in the blood of women with twin pregnancies and in the umbilical cord blood of newborns in relation to environmental factors
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 18, 2024
Background
There
is
a
huge
gap
in
the
knowledge
of
body’s
nutrient
resources
women
with
multiple
gestations.
Due
to
increased
demand
hypothesis
and
taking
into
account
common
vitamin
D
deficits
singleton
pregnancies,
this
issue
should
also
be
investigated
twin
pregnancies.
This
study
evaluated
blood
concentration
pregnancies
umbilical
cord
their
newborns
as
well
analyzed
environmental
factors
that
may
affect
level
nutrient.
Methods
The
included
56
Venous
samples
were
collected
from
before
delivery
at
determine
total
25(OH)D
concentration.
interviewed
by
dietitian
collect
data
on
diet
lifestyle.
Results
average
maternal
concentrations
38.4
±
11.0
ng/mL
vs.
23.7
6.1
determined
newborns.
was
strongly
correlated
mother
(
p
<
0.001).
Vitamin
deficiency
found
7%
21%
Factors
increasing
risk
too
low
mothers
age
below
27
years
=
0.002)
short
duration
pregnancy
0.011).
In
newborns,
0.001)
36
weeks
gestation
0.008).
mean
levels
almost
identical
both
twins
amounted
24.0
first-born
23.4
second-born
infant.
supplementation
declared
98%
women,
85%
≤2,000
IU
daily.
Conclusion
Only
small
percentage
presented
deficiency,
which
probably
related
widespread
It
can
therefore
assumed
dose
2,000
currently
recommended
for
pregnant
appropriate
gestations,
although
further
research
required
validate
finding.
Language: Английский
THE IMPACT OF VITAMIN D DEFICIENCY ON P65 NF-KB ACTIVITY IN THE PATHOGENESIS OF PLACENTAL DYSFUNCTION
Medical Science of Ukraine (MSU),
Journal Year:
2024,
Volume and Issue:
20(4), P. 27 - 35
Published: Dec. 30, 2024
Aim:
To
study
the
role
of
vitamin
D
in
activation
nuclear
factor
kB
(NF-kB)
as
a
development
placental
disorders.
Materials
and
methods:
The
involved
135
women
who
were
observed
gave
birth
at
Municipal
Non-Profit
Enterprise
"Perinatal
Center
Kyiv."
research
was
conducted
case-control
study,
including
105
pregnant
main
group
with
dysfunction
(Group
I
–
70
deficiency
below
20
ng/ml,
Group
II
35
between
30
ng/ml)
control
physiological
course
pregnancy
uncomplicated
term
deliveries.
concentration
25(OH)D
blood
measured
using
immunoassay
method
Monobind
reagent
kit
(USA)
Sinnova
ER
500
microplate
reader
(China).
determination
p65
NF-kB
carried
out
RayBio
Human
Procalcitonin
ELISA
(RayBiotech,
Inc.,
USA)
Phospho-NF-kB
P65
(Ser536)
Total
Kit.
Statistical
analysis
data
performed
MedStat
v.5.2
EZR
v.3.4.1
software.
Initially,
normality
distribution
checked
Shapiro-Wilk
test,
followed
by
application
multiple
comparisons
Kruskal-Wallis
rank-based
one-way
variance.
significance
determined
p
<
0.05.
Results.
revealed
significant
difference
levels
total
phosphorylated
protein
groups
(p
0.05).
In
deficiency,
there
marked
increase
(median
69.5
pg/ml)
its
activated
form,
indicating
inflammatory
processes
placenta.
Clinical
manifestations
dysfunction,
such
fetal
growth
restriction,
preeclampsia,
preterm
labor,
one-third
deficiency.
This
accompanied
changes
hormonal
function
placenta
(a
decrease
progesterone
stabilization
lactogen)
morphological
signs
abnormalities.
activity
highest
abnormalities,
particularly
link
inflammation
Conclusion.
Vitamin
ng/ml
are
associated
factor,
which
correlates
regardless
outcomes.
confirms
Language: Английский