Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in OVX Rats and BMSCs DOI Open Access
Bingke Xia, Xuan Dai,

Hanfen Shi

et al.

Published: April 3, 2024

Recent interest in preventing the development of osteoporosis has focused on regulation redox homeostasis. However, action lycopene (LYC), a strong natural antioxidant com-pound, osteoporotic bone loss remains largely unknown. Here, we show that administra-tion LYC to OVX rats reduces body weight gain, improves lipid metabolism and preserves quality. In addition, treatment inhibits ROS overgeneration serum marrow rats, BMSCs upon H2O2 stimulation, leading inhibiting adipogenesis pro-moting osteogenesis during remodeling. Mechanically, may improve quality via an increase expressions FoxO1 Runx2, decrease PPARγ C/EBPα BMSCs. Collectively, these findings suggest attenuates through promoting regula-tion FoxO1/PPARγ pathway driven by oxidative stress, presenting novel strategy for os-teoporosis management.

Language: Английский

The role of lycopene in alleviating nanoplastic-induced liver inflammation and steatosis: Insights from gut microbiota remodeling DOI

Sugan Xia,

Chaoyue Yan,

Lan Chen

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104862 - 104862

Published: Aug. 6, 2024

Language: Английский

Citations

1
Effects of lycopene on the growth performance, meat quality, cecal metagenome, and hepatic untargeted metabolome in heat stressed broilers DOI Creative Commons

Huijuan Yang,

Yingsen Liu, Guangtian Cao

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(12), P. 104299 - 104299

Published: Sept. 6, 2024

Language: Английский

Citations

1
Mitigating Salt Stress with Biochar: Effects on Yield and Quality of Dwarf Tomato Irrigated with Brackish Water DOI Creative Commons

M. Lentini,

Michele Ciriello, Youssef Rouphael

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(19), P. 2801 - 2801

Published: Oct. 6, 2024

The increase in the frequency and magnitude of environmental stresses poses a significant risk to stability food supplies. In coastal areas Mediterranean, brackish water has long been considered limitation on horticultural production. this scenario, use biochar agriculture could be valuable tool cope with deleterious effects salt stress. This work aimed investigate, protected environment, different concentrations (0, 1, 2%

Language: Английский

Citations

1
Optimization of lycopene spray drying encapsulation in basil seed gum: Boosting bioavailability and mayonnaise stability DOI

Juyang Zhao,

Ming Liu, Sinan Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136572 - 136572

Published: Oct. 14, 2024

Language: Английский

Citations

1
Lycopene Promotes Osteogenesis and Reduces Adipogenesis through Regulating FoxO1/PPARγ Signaling in OVX Rats and BMSCs DOI Open Access
Bingke Xia, Xuan Dai,

Hanfen Shi

et al.

Published: April 3, 2024

Recent interest in preventing the development of osteoporosis has focused on regulation redox homeostasis. However, action lycopene (LYC), a strong natural antioxidant com-pound, osteoporotic bone loss remains largely unknown. Here, we show that administra-tion LYC to OVX rats reduces body weight gain, improves lipid metabolism and preserves quality. In addition, treatment inhibits ROS overgeneration serum marrow rats, BMSCs upon H2O2 stimulation, leading inhibiting adipogenesis pro-moting osteogenesis during remodeling. Mechanically, may improve quality via an increase expressions FoxO1 Runx2, decrease PPARγ C/EBPα BMSCs. Collectively, these findings suggest attenuates through promoting regula-tion FoxO1/PPARγ pathway driven by oxidative stress, presenting novel strategy for os-teoporosis management.

Language: Английский

Citations

0