A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 7, 2025

Current evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through background knowledge of D, searched in Pubmed [by using key words title containing "randomized trial", "COVID-19", "vitamin (25-hydroxyvitamin cholecalciferol, calcidiol, calcifediol) supplementation"] for publications studies D/supplementation patients, especially those about randomized trials (RCTs). After reviewing these papers, did a short review pathophysiology COVID-19, summarized features 25 RCTs text tabulated table some features, commented, compared discussed differences between (for example, change serum 25-hydroxyvitamin concentration from nmol/L to ng/mL, making comparison easier). The take-home question that an important indicator effect correction but may not be reliable predicting outcomes COVID-19.

Language: Английский

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Vitamin supplementation and its effect on incident type 1 diabetes mellitus and islet autoimmunity: a systematic review and meta-analysis

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

The prevalence of type 1 diabetes mellitus (T1DM) is set to rise annually with long-term implications on the quality-of-life. Supplementation vitamins has garnered interest in recent years due its association development islet autoimmunity (IA) and T1DM. This systematic review aims investigate relationship between supplementation IA or T1DM progression PRISMA-adherent involved a search PubMed, Embase Cochrane for all studies that evaluated odds (pre-calculated pooled OR) risk (RR) IA, T1DM, after vitamins. Random effects meta-analyses were used primary analysis. 15 included. Meta-analyses observed vitamin D did not modify developing (Pooled OR=0.55, 95%CI: 0.22-1.38) OR=0.91, 0.67-1.25). relative was almost significant (RR=0.66, 0.41-1.06), emphasizing need conduct further large-scale cohort studies. Systematic revealed B influence Additionally, there an higher maternal education levels their offspring. In conclusion, we found no benefit use various modifying Our study provides foundation future research by contributing evolving landscape nutritional immunology. https://www.crd.york.ac.uk/prospero/, identifier CRD42024540524.

Language: Английский

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Imunorregulação e suplementação oral da Vitamina D: uma revisão integrativa

Brazilian Journal of Health Review, Journal Year: 2025, Volume and Issue: 8(1), P. e76783 - e76783

Published: Jan. 14, 2025

A suplementação de vitamina D tem-se mostrado promissora na imunorregulação doenças pacientes imunocompetentes. Esta revisão literatura destinou-se a: analisar como a oral atua doenças; considerar relação entre e as variáveis: faixa etária, etnia, localização geográfica etc; citar principais evidências médicas estudos científicos sobre o tratamento da terapia suplementar D; identificar doses restrições importância para sistema imunológico; pesquisar com algumas enfermidades imunocompetentes; elaborar um e-book os conhecimentos levantados neste Artigo. Tratou-se estudo qualitativo, do tipo bibliográfico-analítico, uma integrativa, busca ativa referencial literário científico em imunocomprometidos. Nesse viés, presente comprovou ingestão adequada D.

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Vitamin D Deficiency Meets Hill’s Criteria for Causation in SARS-CoV-2 Susceptibility, Complications, and Mortality: A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 599 - 599

Published: Feb. 6, 2025

Clinical trials consistently demonstrate an inverse correlation between serum 25-hydroxyvitamin D [25(OH)D; calcifediol] levels and the risk of symptomatic SARS-CoV-2 disease, complications, mortality. This systematic review (SR), guided by Bradford Hill’s causality criteria, analyzed 294 peer-reviewed manuscripts published December 2019 November 2024, focusing on plausibility, consistency, biological gradient. Evidence confirms that cholecalciferol (D3) calcifediol significantly reduce hospitalizations, mortality, with optimal effects above 50 ng/mL. While vitamin requires 3–4 days to act, shows within 24 h. Among 329 trials, only 11 (3%) showed no benefit due flawed designs. At USD 2/patient, D3 supplementation is far cheaper than hospitalization costs more effective standard interventions. SR establishes a strong relationship 25(OH)D vulnerability, meeting criteria. Vitamin infections, deaths ~50%, outperforming all patented, FDA-approved COVID-19 therapies. With over 300 confirming these findings, waiting for further studies unnecessary before incorporating them into clinical protocols. Health agencies scientific societies must recognize significance results incorporate prophylaxis early treatment protocols similar viral infections. Promoting safe sun exposure adequate communities maintain 40 ng/mL (therapeutic range: 40–80 ng/mL) strengthens immune systems, reduces hospitalizations deaths, lowers healthcare costs. When exceed 70 ng/mL, taking K2 (100 µg/day or 800 µg/week) alongside helps direct any excess calcium bones. The recommended dosage (approximately IU/kg body weight non-obese adult) 50–100 cost-effective disease prevention, ensuring health outcomes.

Language: Английский

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Assessing the impact of 25-hydroxyvitamin concentrations on mortality in chronic diarrhea: a cross-sectional analysis

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 14, 2025

Background The aim of this study was to assess the relationship between serum 25-hydroxyvitamin levels and all-cause mortality in patients with chronic diarrhea. Methods We carried out a cross-sectional using information drawn from National Health Nutrition Examination Survey (NHANES). To outcomes, we compared our data records Death Index as December 31, 2011. NHANES were used determine outcome. Cox regression model-based approach analyze concentrations diarrhea patients. Results A total 2,972 participants included study, 488 cases recorded. showed an L-shaped threshold 73.40 nmol/L. On left side threshold, each 1-unit increase associated 2.2% reduction risk (HR 0.978; 95% CI: 0.969, 0.987); however, on right there no significant correlation 25(OH)D mortality. Conclusion Serum D association diarrhea, nmol/L potential threshold. However, because only association, not causal relationship, can be inferred. Further prospective studies are needed confirm these findings explore impact vitamin supplementation outcomes.

Language: Английский

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Preventing Recurrent Otitis Media in Children Aged 2–7 Years: A Cross-Sectional Evaluation of Serum Vitamin D as a Modifiable Factor

Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 519 - 519

Published: Feb. 20, 2025

Background/Objectives: Otitis media (OM) is a common pediatric condition that significantly impacts hearing, language development, and quality of life. Emerging evidence suggests vitamin D plays crucial role in immune regulation deficiency may predispose children to recurrent OM. This study aimed evaluate whether low serum levels are associated with increased incidence severity OM aged 2-7 years. Methods: A cross-sectional was conducted at otolaryngology clinic northwest Romania between November 2023 April 2024. total 118 were enrolled, including 87 documented episodes within the preceding six months 31 quasi-controls without recent episodes. Participants stratified into three age groups (2-3, 4-5, 6-7 years) classified clinical subtypes (Acute Suppurative Media, Serous Acute Congestive Media). Serum 25-hydroxyvitamin measured using chemiluminescence immunoassay categorized as deficient (≤20 ng/mL), insufficient (21-29 or sufficient (≥30 ng/mL). Statistical analyses included one-way ANOVA post-hoc tests, chi-square linear regression, logistic Poisson regression. Results: Children exhibited lower compared controls, most pronounced observed group. One-way revealed significant differences among (F(3,114) = 82.30, p < 0.001), regression demonstrated strong inverse correlation frequency (r -0.793, adjusted R2 0.63, 0.001). Logistic indicated insufficiency odds (OR ≈ 120.74, while showed rate ratios 13.62 for 10.47 status (p Conclusions: The findings indicate an risk otitis preschool-aged children. These results support independent, modifiable factor OM, suggesting screening supplementation could be beneficial reducing economic burden this condition.

Language: Английский

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How Can We Increase the Clinical Benefits of Vitamin D Supplementation in Adult People with Multiple Sclerosis?

Journal of Medical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Vitamin D (VD) supplementation in adult people with multiple sclerosis (MS) remains most of the time suboptimal, linked to outdated prescription rules mainly based on good bone health. In MS, physician should ensure that have a normal serum 25-hydroxyvitamin level for maintenance an effective immune system. Here, we highlight pitfalls classically encountered this population and propose simple algorithm optimal supplementation.

Language: Английский

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Immune-Boosting Potential of Food Bioactives

Published: Jan. 1, 2025

Language: Английский

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Genetic Evidence Indicates that Serum Micronutrient Levels Mediate the Causal Relationships Between Immune Cells and Neuropathic Pain: A Mediation Mendelian Randomization Study

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

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A Fresh Look at Problem Areas in Research Methodology in Nutrition

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 972 - 972

Published: March 10, 2025

This paper makes a critical evaluation of several the research methods used to investigate relationship between diet, health, and disease. The two widely are randomized controlled trials (RCTs) prospective cohort studies. RCTs viewed as being more reliable than studies for that reason placed higher in hierarchy. However, have inherent flaws and, consequently, they may generate findings less those from text presents discussion errors occur result confounding. refers correlation exposure outcome with other variables can mask true association or produce false associations. Another source error is reverse causation, which most commonly associated cross-sectional These do not allow researchers determine temporal sequence lifestyle inputs together health-related outcomes. As result, it be unclear cause effect. also illustrated by inverse alcohol intake coronary heart Mechanistic investigation intricate details body functioning health disease this strategy biomedical science. evidence presented here case our information practical value field nutrition has come epidemiological research, including RCTs, whereas mechanistic been minor value.

Language: Английский

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