Defatted Hickory Meal Hydrolysate's Impact on Memory Impairment Induced by D-Galactose in Mice DOI Creative Commons

Fanping Qin,

Ruiling Liu,

Qi Kong

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Defatted hickory meal (DHM), a by-product of oil production, is protein source rich in essential amino acids. In this study, the functional properties DHM hydrolysate (DHMH) were assessed using in vitro and vivo assays context to its antioxidant memory-enhancing effects. To induce memory impairment, D-galactose (D-gal) was administered mice at dose 120 mg/kg body weight per day, DHMH orally doses 300, 600, 1000 day for 8 weeks. treatment led improved performance D-gal-induced memory-impaired mice, as observed Morris water maze test. Furthermore, mitigated accumulation amyloid beta 1-42 triggered by D-gal exposure. Notably, high-dose significantly reduced elevation pro-inflammatory markers, including tumor necrosis factor alpha, interleukin 1β, 6. Additionally, prevented decline total superoxide dismutase activity, glutathione peroxidase levels, while reducing malondialdehyde content indicative properties. Moreover, effectively histological alterations neurons within hippocampal CA1 area induced D-gal. Collectively, our findings suggest that may counteract dysfunctions resulting from oxidative stress injury brain, positioning it potential candidate use food.

Language: Английский

Curing Strategies and Bioactive Peptide Generation in Ham: In Vitro and in Silico Evaluation DOI

Noelia Hernández Correas,

Ana Martı́nez, Adela Abellán

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Curing strategies and bioactive peptide generation in ham: In vitro digestion and in silico evaluation DOI Creative Commons

Noelia Hernández Correas,

Ana Martı́nez, Adela Abellán

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 484, P. 144360 - 144360

Published: April 15, 2025

Language: Английский

Citations

0
The Discovery of Novel Indoleamine-2,3-Dioxygenase 1 Inhibitors from Walnut Protein Hydrolysates: Screening, Inhibitory Mechanism, and Molecular Dynamic Simulations DOI
Xiao Xiao, Aijin Ma, Siting Li

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Defatted Hickory Meal Hydrolysate's Impact on Memory Impairment Induced by D-Galactose in Mice DOI Creative Commons

Fanping Qin,

Ruiling Liu,

Qi Kong

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Defatted hickory meal (DHM), a by-product of oil production, is protein source rich in essential amino acids. In this study, the functional properties DHM hydrolysate (DHMH) were assessed using in vitro and vivo assays context to its antioxidant memory-enhancing effects. To induce memory impairment, D-galactose (D-gal) was administered mice at dose 120 mg/kg body weight per day, DHMH orally doses 300, 600, 1000 day for 8 weeks. treatment led improved performance D-gal-induced memory-impaired mice, as observed Morris water maze test. Furthermore, mitigated accumulation amyloid beta 1-42 triggered by D-gal exposure. Notably, high-dose significantly reduced elevation pro-inflammatory markers, including tumor necrosis factor alpha, interleukin 1β, 6. Additionally, prevented decline total superoxide dismutase activity, glutathione peroxidase levels, while reducing malondialdehyde content indicative properties. Moreover, effectively histological alterations neurons within hippocampal CA1 area induced D-gal. Collectively, our findings suggest that may counteract dysfunctions resulting from oxidative stress injury brain, positioning it potential candidate use food.

Language: Английский

Citations

0