Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 2, 2024
Abstract
Background:
Oxidative
stress
plays
a
critical
role
in
the
progression
of
pre-eclampsia
and
gestational
hypertension.
The
body's
own
antioxidant
system
(including
GST,
CAT,
GPX,
SOD)
dietary
intake
antioxidants
such
as
vitamin
A
(retinol),
carotene,
C,
E
have
been
proven
to
counter
oxidative
stress-related
damage.
However,
no
comprehensive
studies
explored
correlation
between
these
factors
risk
[5]
Methods:
Instrumental
variables
(IVs)
for
four
mentioned
were
obtained
from
largest
GWAS
dataset
based
on
UK
Biobank
data,
followed
by
two-sample
Mendelian
randomization
study.
IVs,
F-statistics,
Cochran’s
Q
tests,
sensitivity
analysis
used
examine
causal
relationship
intake,
stress,
statistics
quantify
heterogeneity
instrumental
variable
estimates.
[7]
Results:
IVW
method
indicated
an
approximate
5.0%
decreased
hypertension
per
standard
deviation
(SD)
increase
SOD
(OR
=
0.95;
95%
CI
0.90-1.00,
p
0.048).
For
other
biomarkers
vitamins,
significant
effects
observed
(Retinol:
0.79
(0.56–1.11),
0.18;
Carotene:
1.03
(0.78–1.36),
0.81;
Vitamin
C:
(0.57–1.10),
0.16;
E:
1.16
(0.86–1.56),
0.32;
GST:
1.00
(0.96–1.05),
0.93;
CAT:
0.88;
GPX:
1.01
(0.96–1.06),
0.74).
Similar
results
found
pre-eclampsia.
[9]
Conclusion:
This
study
suggests
that
is
closely
related
supplements
A,
E,
carotenoids
did
not
show
improvement
or
[11]
