Possible impact of use of a ketogenic diet in pregnancy on the fetus: Review of animal and human studies

NFS Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100212 - 100212

Published: Jan. 1, 2025

Language: Английский

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Do Popular Diets Impact Fertility?

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1726 - 1726

Published: May 31, 2024

Infertility affects 15% of the population in developed countries, and its prevalence is increasing. Fertility can be influenced by different factors. Although key factors like maternal age cannot changed, there growing evidence that other modifiable factors, such as diet, have an impact on fertility. Diet has become increasingly important recent years for a number reasons: new trend toward healthy lifestyle, higher certain digestive disorders, lack time leads people to consume more prepared processed food, personal choice not eat meat, among others. To meet these needs, several diets recently popular, Mediterranean known gold standard health; DASH preventing hypertension; Western characterized food; ketogenic low carbohydrate intake; vegetarian which who do meat or animal by-products. Diets present unique composition presence absence specific nutrients, also been associated with male female fertility individually. This review assesses macro- micronutrients both

Language: Английский

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The Effect of Prebiotics, Alone or as Part of Synbiotics, on Cardiometabolic Parameters in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 177 - 177

Published: Jan. 13, 2025

Background/Objectives: This systematic review and meta-analysis aimed to investigate the effect of prebiotics, alone or as part synbiotics, on cardiometabolic parameters in polycystic ovary syndrome (PCOS) women. Methods: Databases, including PubMed, Scopus, ISI Web Science, Embase, Cochrane Central Register Controlled Trials, were searched for relevant randomized-controlled trials (RCTs) until 12 December 2024. Changes mean ± standard deviations extracted combined using a random-effects model. Bias was assessed risk bias evidence quality with GRADE. Results: Twenty RCTs 1271 participants included. Results showed high-quality supporting prebiotics’ effects, reducing body-mass index [n = 853; weighted-mean difference (WMD): −0.510, 95%CI: −0.669, −0.351 kg/m2] diastolic blood pressure (WMD: −2.218, −4.425, −0.010 mmHg), moderate-quality weight, waist-to-hip ratio, triglycerides improvements, low very-low-quality waist circumference (WC), fat mass, fasting plasma glucose, insulin, low-density lipoprotein (LDL), total cholesterol (TC), high sensitive-C reactive protein, testosterone, follicle-stimulating hormone free androgen improvements. Subgroup analyses revealed possible reduction LDL well decreases WC, TC, testosterone synbiotics. Dietary approaches stop hypertension diet improved insulin sensitivity. Conclusions: study suggests that prebiotics may beneficially affect several PCOS Approximately one-third results based moderate-to-high-quality evidence. highlights need future well-designed, larger longer treatment duration strengthen base guide clinical decision-making.

Language: Английский

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Impact of Polycystic Ovary Syndrome Hyperandrogenic Phenotypes A and Non-Hyperandrogenic D on Pregnancy Outcomes After in vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI)

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 561 - 569

Published: March 1, 2025

This study aims to evaluate the association between polycystic ovary syndrome (PCOS) phenotypes A and D with primary secondary pregnancy outcomes among PCOS vs non-PCOS patients after in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). retrospective cohort design using data of eligible women aged 20-40 years who had their first IVF treatment. The were obtained from medical records. either diagnosed according Rotterdam Criteria, namely or non-PCOS. Pregnancy outcome including (1) rate biochemical (2) ongoing clinical (3) miscarriage measured. Furthermore, collected on number oocytes retrieved, percentage mature oocytes, rate, (4) grade 1 embryos day 3 (5) 5. sample 149 was analyzed. For outcomes, in groups have lower oocyte maturity ratio, as well fewer comparison control. Primary significantly values group respect higher rates control group. Finally, did not differ outcomes. Patients phenotype better A. Phenotype A, affects negatively possibly due hyperandrogenism.

Language: Английский

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Traditional Dietary Approaches for PCOS: A Review of Conventional Dietary Recommendations for PCOS and Their Limitations

Published: Jan. 1, 2025

Language: Английский

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Advancing Obesity Management: the Very Low-Energy Ketogenic therapy (VLEKT) as an Evolution of the “Traditional” Ketogenic Diet

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: April 3, 2025

This narrative review comprehensively analyzes VLEKT as an advanced nutritional strategy for obesity management. The focus is on the beneficial effects key disease organs, such adipose tissue and liver, well modulation of intestinal permeability its fundamental role in influencing gut microbiota inflammatory pathways. impact obesity-related comorbidities, including metabolic syndrome, cardiovascular disease, endocrine disorders, dysfunction-associated steatotic liver (MASLD), neurological kidney alterations, also investigated. Moreover, to assess wider application treatment, combination ketogenic regimes with additional strategies physical activity, bariatric surgery, digital health technologies examined. Despite promising clinical results, adherence potential deficiencies require careful follow-up individualized programming monitored by specialists. Future research should elucidating molecular mechanisms underlying physiological systems, long-term safety. Nevertheless, innovative approach offering a target-oriented highly effective people fighting against overweight associated medical complications. Obesity multifactorial chronic numerous comorbidities; given increasing prevalence, personalized intervention are crucial inhibit "obesity pandemic" according "food re-educational" protocol. Among dietary interventions, diet (KD) has attracted attention effectiveness weight management benefits. A variant, very low-calorie (VLCKD), more recently defined low-energy (VLEKD), combines benefits ketosis substantial calorie restriction, improving overall health.

Language: Английский

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Evaluation of Anti-Müllerian Hormone (AMH) Serum Levels in Patients with Polycystic Ovary Syndrome (PCOS) Depending on Body Mass Index (BMI)

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2677 - 2677

Published: April 14, 2025

The relationship between anti-Müllerian hormone (AMH) levels and body weight, expressed through mass index (BMI), in women with PCOS has been a topic of discussion for long time, yet the literature continues to present conflicting data. latest guidelines emphasize growing role AMH diagnosis polycystic ovary syndrome suggest that it should become one diagnostic criteria identifying this condition. Objectives: aim study was determine BMI reproductive-age patients. bioethics committee approved conduct study. Methods: A total 193 patients diagnosed (PCOS) based on Rotterdam were included group. control group consisted 196 who did not meet PCOS. Blood samples (5 mL venous blood) collected from all participants levels. Additionally, weight height measured, calculated. Results: mean level 7.187 ng/mL (median: 6.400 ng/mL) more than twice as high without (mean: 3.399 ng/mL, median: 2.835 ng/mL). decline average occurs at an older age (35–39 years) compared (25–29 years). significant negative correlation observed only 25–29 In 20–24 group, takes form statistical tendency. Conclusions: Obesity is modifiable factor influencing demonstrated may contribute development therapeutic protocols tailored patient’s clinical

Language: Английский

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Reply to Cetkovic et al. Comment on “Meneghini et al. The Impact of Nutritional Therapy in the Management of Overweight/Obese PCOS Patient Candidates for IVF. Nutrients 2023, 15, 4444”

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 439 - 439

Published: Feb. 1, 2024

Thanks for your comment [...]

Language: Английский

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Comment on Meneghini et al. The Impact of Nutritional Therapy in the Management of Overweight/Obese PCOS Patient Candidates for IVF. Nutrients 2023, 15, 4444

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 417 - 417

Published: Jan. 31, 2024

We read with great interest the recent article by Meneghini et al. on assessment of effects different alimentary regimens, included Mediterranean diet (MD), polycystic ovary syndrome (PCOS) patients prior to in vitro fertilization cycles [...].

Language: Английский

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The Potential for Ketogenic Diets to Control Glucotoxicity, Hyperinsulinemia, and Insulin Resistance to Improve Fertility in Women with Polycystic Ovary Syndrome

Clinical and Experimental Obstetrics & Gynecology, Journal Year: 2024, Volume and Issue: 51(3), P. 57 - 57

Published: March 4, 2024

Objective: This review aims to summarize the association between insulin resistance (IR) and symptoms of Polycystic Ovary Syndrome (PCOS) while explaining how nutritional interventions, specifically ketogenic diets, help manage PCOS. Mechanism: The effect IR on diagnostic criteria for PCOS is first described, followed by a standard diet exacerbates IR. Afterward, women with PCOS, are described. Findings in Brief: associated ovulatory dysfunction, hyperandrogenism, polycystic ovarian morphology, which leads metabolic abnormalities loss fertility. Activation polyol pathway, advanced glycation end-product accumulation, hexosamine flux hyperglycemia involved phenotypes reproduction alterations. affects oocytes, ovaries, endometrium among leading infertility. However, were shown lower serum cholesterol, triglycerides, androstenedione, testosterone attenuate At same time, high-density lipoprotein increased, promoting menstrual regularity and, eventually, providing better environment vitro fertilization. Conclusion: For managing essential their improving Resolving glucotoxicity caused excessive dietary glucose crucial prevention correction damage hyperinsulinemia hyperglycemia, contributing

Language: Английский

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