The Impact of Gestational Diabetes Mellitus on Minipuberty in Girls DOI Open Access
Karolina Kowalcze, Sofia Burgio, Giuseppe Gullo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11766 - 11766

Published: Nov. 1, 2024

Minipuberty is the second phase of physiological activation reproductive axis, playing a role in postnatal development sexual organs. The course female minipuberty was found to be affected by low maternal vitamin D status and hypothyroidism during pregnancy. aim current study assess hormonal profile size organs daughters mothers with gestational diabetes mellitus. included three matched groups infant girls: healthy women without metabolic disorders pregnancy (group 1), poorly controlled mellitus 2), adequately 3). Urinary levels gonadotropins, salivary estradiol, testosterone, DHEA-S progesterone, ovarian volume, uterine length breast diameter were measured from month 1 18. Concentrations FSH, LH estradiol higher, while concentration progesterone lower group 2 than remaining groups. There no between-group differences concentrations testosterone DHEA-S. Levels LH, correlated whole-blood glycated hemoglobin. Group also characterized longest detection periods for estradiol. Ovarian greater two Over entire observation period, there hormone sizes between 3. obtained results suggest that controlled, but not well affects minipuberty.

Language: Английский

The Course of Minipuberty in Daughters of Women with Low Gestational Vitamin D Status DOI Open Access
Karolina Kowalcze, Robert Krysiak, Giuseppe Gullo

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2362 - 2362

Published: July 21, 2024

Minipuberty is a term describing temporary, sex-specific activation of the hypothalamic–pituitary–gonadal axis, which implicated in development male and female genital organs. Sons women with low vitamin D during gestation were found to be characterized by increased activity reproductive axis faster postnatal growth The current study assesses for first time course minipuberty descendants deficit. population included three matched groups infant girls: children born deficiency (25OHD concentration below 50 nmol/L), offspring insufficiency between 75 daughters healthy females 150 nmol/L). Salivary concentrations estradiol, progesterone, 17-hydroxyprogesterone androgens, as well urine FSH LH, assayed 18 months life (once month 6 months, bimonthly 12, then every months). At each visit, beyond hormone measurements, investigators assessed size organs: ovaries, uterus breasts. In mothers deficiency, FSH, LH estradiol higher detectable longer period time, while ovarian volume, uterine length breast diameter greater than remaining groups. Children levels females, though detection was same, both differed diameter. These findings suggest that status leads more pronounced longer-lasting associated dimensions sexual organs, magnitude depends on degree

Language: Английский

Citations

4
Minipuberty in Daughters of Women with Hypothyroidism during Pregnancy DOI Open Access
Karolina Kowalcze, Robert Krysiak,

Joanna Kula-Gradzik

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8244 - 8244

Published: July 28, 2024

Minipuberty is a term describing transient postnatal activation of the hypothalamic-pituitary-gonadal axis, likely playing an important role in growth female genital organs and breasts. Unlike infant boys, there are no data concerning impact gestational hypothyroidism on course minipuberty girls. Therefore, aim current study was to investigate reproductive axis daughters women with thyroid hypofunction during pregnancy. The population included three matched groups girls: offspring non-substituted or inadequately treated gestation (group 1), descendants adequately substituted throughout pregnancy 2), healthy 3). Salivary concentrations estradiol, progesterone, 17-hydroxyprogesterone, androgens (testosterone, androstenedione, dehydroepiandrosterone sulfate) urine levels gonadotropins were measured monthly from month 1 6, once every two months between 6 12, 12 18. During each visit, we also determined ovarian volume, uterine length, breast diameter. Concentrations FSH, LH, estradiol lowest group 1, this characterized by shortest detection period for estradiol. These differences paralleled There 2 3 both hormones size structures. obtained results seem indicate that may impair offspring.

Language: Английский

Citations

3
Associations of pentachlorophenol exposure during pregnancy with maternal and infant reproductive hormones based on a birth cohort DOI

Yitao Huo,

Yanjian Wan, Ying Li

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 932, P. 172723 - 172723

Published: April 25, 2024

Language: Английский

Citations

2
Interaction between Vitamin D homeostasis, gut microbiota, and central precocious puberty DOI Creative Commons

Dou-Dou Guo,

Xin Ning, Tao Bai

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Central precocious puberty (CPP) is an endocrine disease in children, characterized by rapid genital development and secondary sexual characteristics before the age of eight girls nine boys. The premature activation hypothalamic-pituitary-gonadal axis (HPGA) limits height patients adulthood associated with a higher risk breast cancer. How to prevent improve prognosis CPP important problem. Vitamin D receptor (VDR) widely expressed reproductive system, participates synthesis function regulatory sex hormones, affects gonads. In addition, gut microbiota plays role human health mainly regulating metabolites, energy homeostasis, hormone regulation. This review aims clarify effect vitamin deficiency on occurrence explore it. Although evidence interaction between deficiency, microbiota, remains limited, supplementation interventions offer promising, non-invasive strategy for managing CPP.

Language: Английский

Citations

1
The Impact of Maternal Gestational Diabetes Mellitus on Minipuberty in Boys DOI Open Access
Karolina Kowalcze, Sofia Burgio, Johannes Ott

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4145 - 4145

Published: Nov. 29, 2024

Minipuberty is thought to play an important role in the sexual maturation of infants. Maternal disorders during pregnancy were found have impact on activity reproductive axis first year life. This prospective, matched, cohort study was aimed at investigating whether course minipuberty boys affected by maternal gestational diabetes mellitus (GDM).

Language: Английский

Citations

0
Minipuberty in Full-term and Preterm Asian Indian Infants: The First Glance DOI
Vijaya Sarathi

Indian Pediatrics, Journal Year: 2024, Volume and Issue: 61(3), P. 219 - 220

Published: March 1, 2024

Language: Английский

Citations

0
The Impact of Gestational Diabetes Mellitus on Minipuberty in Girls DOI Open Access
Karolina Kowalcze, Sofia Burgio, Giuseppe Gullo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11766 - 11766

Published: Nov. 1, 2024

Minipuberty is the second phase of physiological activation reproductive axis, playing a role in postnatal development sexual organs. The course female minipuberty was found to be affected by low maternal vitamin D status and hypothyroidism during pregnancy. aim current study assess hormonal profile size organs daughters mothers with gestational diabetes mellitus. included three matched groups infant girls: healthy women without metabolic disorders pregnancy (group 1), poorly controlled mellitus 2), adequately 3). Urinary levels gonadotropins, salivary estradiol, testosterone, DHEA-S progesterone, ovarian volume, uterine length breast diameter were measured from month 1 18. Concentrations FSH, LH estradiol higher, while concentration progesterone lower group 2 than remaining groups. There no between-group differences concentrations testosterone DHEA-S. Levels LH, correlated whole-blood glycated hemoglobin. Group also characterized longest detection periods for estradiol. Ovarian greater two Over entire observation period, there hormone sizes between 3. obtained results suggest that controlled, but not well affects minipuberty.

Language: Английский

Citations

0