Metabolism Open, Journal Year: 2024, Volume and Issue: 23, P. 100315 - 100315
Published: Aug. 30, 2024
Approximately 25 % of diabetic patients develop foot ulcers (DFUs), significantly increasing morbidity, mortality, and healthcare costs. Effective control prevention are crucial.
Language: Английский
Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 575 - 575
Published: March 24, 2025
Background and Objectives: This study examined the prevalence risk factors of dynapenia, pre-sarcopenia, sarcopenia among Korean adults using nationally representative data. Materials Methods: A cross-sectional analysis was conducted 2022–2023 Korea National Health Nutrition Examination Survey (KNHANES). Participants aged 20 years older with available muscle strength body composition measurements were included. Handgrip skeletal mass (measured via bioelectrical impedance analysis) used to classify participants based on Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Logistic regression identified associated factors. Results: The 9.6%, 3.4%, 1.6%, respectively. Pre-sarcopenia most common across all age groups, while primarily observed in (p < 0.001). Age a key predictor three conditions 0.001), sex differences—men had higher pre-sarcopenia = 0.014), whereas women showed rates dynapenia 0.003) 0.008). Low physical activity high stress 0.021), smoking 0.012) also significant Conclusions: These findings highlight importance early identification targeted interventions prevent deterioration. Public health strategies focusing lifestyle modifications sex-specific approaches may help mitigate burden its related complications aging populations.
Language: Английский
Citations
1
Diabetology International, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Language: Английский
Citations
0
Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2025, Volume and Issue: 16(2)
Published: March 3, 2025
Muscle atrophy is a severe complication of diabetes, with autophagy playing critical role in its progression. Zinc has been shown to alleviate hyperglycaemia and several diabetes-related complications, but direct mediating diabetic muscle remains unclear. This study explores the potential zinc pathogenesis atrophy. In vivo, C57BL/6J mice were induced diabetes by streptozotocin (STZ) treated ZnSO₄ (25 mg/kg/day) for six weeks. Gastrocnemius muscles collected histological analysis, including transmission electron microscopy (TEM). Serum levels measured ICP-MS. Protein expression was evaluated using immunofluorescence (IF), immunohistochemistry (IHC) Western blotting (WB). Bioinformatics analysis used identify key genes associated vitro, high-glucose-induced C2C12 cell model established received ZnSO₄, rapamycin, SRT1720, TC-G-1008, or GPR39-CRISPR Cas9 intervention. Autophagy observed TEM, protein assessed IF WB. Intracellular concentrations fluorescence resonance energy transfer (FRET). atrophy, activation, upregulation SIRT1 FoxO1, along downregulation GPR39, confirmed T1D group. protected against inhibited (T1D + vs. T1D, all p < 0.0001), as evidenced increased grip strength (212.40 ± 11.08 163.90 10.95 gf), gastrocnemius index (10.67 0.44 8.80 0.72 mg/g), fibre cross-sectional area (978.20 144.00 580.20 103.30 μm2), serum (0.2335 0.0227 0.1561 0.0123 mg/L). down-regulated Atrogin-1 MuRF1, decreased formation autophagosomes (all 0.0001). RNA-seq indicated activation SIRT1/FoxO1 signalling pathway mice. LC3B, while upregulating P62 GPR39 0.05). down-regulation Both TC-G-1008 Atrogin-1, SIRT1, up-regulated inhibiting improving The beneficial anti-atrophic effects are diminished following treatment SRT1720 RAPA. Upon knockout, upregulated, downregulated. ZnSO₄-treated group remained unchanged (p > 0.05), indicating that supplementation did not affect ion entry acted through surface receptor GPR39. ZnSO4 inhibits excessive skeletal alleviates via GPR39-SIRT1/FoxO1 axis. These findings suggest may offer therapeutic strategy managing
Language: Английский
Citations
0
Pediatric Diabetes, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Background: Myokines are secreted by skeletal muscle and play a role in their metabolic function crosstalk with various tissues. appear to be involved the pathogenesis of obesity type 2 diabetes (T2D), yet little is known regarding 1 (T1D). Aim: To assess levels clinical correlates panel five myokines, comparing adolescents recent‐onset T1D, prolonged disease, healthy controls. Methods: Fifty‐eight participated; 20 over 7 years 18 controls were included. Clinical laboratory data collected, including Apelin, Irisin, Interleukin‐6 (IL‐6), Fibroblast growth factor 21 (FGF21), Myostatin. Results: Apelin lower patients T1D compared controls, (117.9 ± 94.3, 228.3 181.6, 224.4 138.4 pg/ml, respectively; analysis variance (ANOVA) p = 0.029). Other myokines did not differ significantly between groups. correlated fasting C‐peptide ( r 0.337, 0.010). In myostatin positively insulin doses (total daily dose 0.590, 0.006 basal 0.645, 0.002). Both apelin negatively diastolic blood pressure (BP) percentile − 0.324, 0.013; 0.302, 0.024, respectively). Conclusions: Our results demonstrate apelin, myokine related beneficial effects muscle, T1D. The correlations may reflect relationship beta‐cell sensitivity.
Language: Английский
Citations
0
Nutrition, Journal Year: 2024, Volume and Issue: 126, P. 112537 - 112537
Published: July 20, 2024
In an era when telemedicine is becoming increasingly essential, the development and validation of miniaturized Bioelectrical Impedance Analysis (BIA) devices for accurate reliable body composition assessment crucial. This study investigates BIA Metadieta, a novel device, by comparing its performance with that standard hospital equipment across diverse demographic. The aim to enhance remote health monitoring integrating compact efficient technology into routine healthcare practices.
Language: Английский
Citations
2
Metabolism Open, Journal Year: 2024, Volume and Issue: 23, P. 100315 - 100315
Published: Aug. 30, 2024
Approximately 25 % of diabetic patients develop foot ulcers (DFUs), significantly increasing morbidity, mortality, and healthcare costs. Effective control prevention are crucial.
Language: Английский
Citations
0