Prevalence and Associated Factors of Dynapenia, Pre-Sarcopenia, and Sarcopenia in Korean Adults: A Cross-Sectional Epidemiological Study
Medicina,
Journal Year:
2025,
Volume and Issue:
61(4), P. 575 - 575
Published: March 24, 2025
Background
and
Objectives:
This
study
examined
the
prevalence
risk
factors
of
dynapenia,
pre-sarcopenia,
sarcopenia
among
Korean
adults
using
nationally
representative
data.
Materials
Methods:
A
cross-sectional
analysis
was
conducted
2022–2023
Korea
National
Health
Nutrition
Examination
Survey
(KNHANES).
Participants
aged
20
years
older
with
available
muscle
strength
body
composition
measurements
were
included.
Handgrip
skeletal
mass
(measured
via
bioelectrical
impedance
analysis)
used
to
classify
participants
based
on
Asian
Working
Group
for
Sarcopenia
(AWGS)
2019
criteria.
Logistic
regression
identified
associated
factors.
Results:
The
9.6%,
3.4%,
1.6%,
respectively.
Pre-sarcopenia
most
common
across
all
age
groups,
while
primarily
observed
in
(p
<
0.001).
Age
a
key
predictor
three
conditions
0.001),
sex
differences—men
had
higher
pre-sarcopenia
=
0.014),
whereas
women
showed
rates
dynapenia
0.003)
0.008).
Low
physical
activity
high
stress
0.021),
smoking
0.012)
also
significant
Conclusions:
These
findings
highlight
importance
early
identification
targeted
interventions
prevent
deterioration.
Public
health
strategies
focusing
lifestyle
modifications
sex-specific
approaches
may
help
mitigate
burden
its
related
complications
aging
populations.
Language: Английский
Exploring the significance of phase angle in diabetes management: a narrative review
Diabetology International,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 8, 2025
Language: Английский
Zinc Alleviates Diabetic Muscle Atrophy via Modulation of the SIRT1/FoxO1 Autophagy Pathway Through GPR39
Journal of Cachexia Sarcopenia and Muscle,
Journal Year:
2025,
Volume and Issue:
16(2)
Published: March 3, 2025
Muscle
atrophy
is
a
severe
complication
of
diabetes,
with
autophagy
playing
critical
role
in
its
progression.
Zinc
has
been
shown
to
alleviate
hyperglycaemia
and
several
diabetes-related
complications,
but
direct
mediating
diabetic
muscle
remains
unclear.
This
study
explores
the
potential
zinc
pathogenesis
atrophy.
In
vivo,
C57BL/6J
mice
were
induced
diabetes
by
streptozotocin
(STZ)
treated
ZnSO₄
(25
mg/kg/day)
for
six
weeks.
Gastrocnemius
muscles
collected
histological
analysis,
including
transmission
electron
microscopy
(TEM).
Serum
levels
measured
ICP-MS.
Protein
expression
was
evaluated
using
immunofluorescence
(IF),
immunohistochemistry
(IHC)
Western
blotting
(WB).
Bioinformatics
analysis
used
identify
key
genes
associated
vitro,
high-glucose-induced
C2C12
cell
model
established
received
ZnSO₄,
rapamycin,
SRT1720,
TC-G-1008,
or
GPR39-CRISPR
Cas9
intervention.
Autophagy
observed
TEM,
protein
assessed
IF
WB.
Intracellular
concentrations
fluorescence
resonance
energy
transfer
(FRET).
atrophy,
activation,
upregulation
SIRT1
FoxO1,
along
downregulation
GPR39,
confirmed
T1D
group.
protected
against
inhibited
(T1D
+
vs.
T1D,
all
p
<
0.0001),
as
evidenced
increased
grip
strength
(212.40
±
11.08
163.90
10.95
gf),
gastrocnemius
index
(10.67
0.44
8.80
0.72
mg/g),
fibre
cross-sectional
area
(978.20
144.00
580.20
103.30
μm2),
serum
(0.2335
0.0227
0.1561
0.0123
mg/L).
down-regulated
Atrogin-1
MuRF1,
decreased
formation
autophagosomes
(all
0.0001).
RNA-seq
indicated
activation
SIRT1/FoxO1
signalling
pathway
mice.
LC3B,
while
upregulating
P62
GPR39
0.05).
down-regulation
Both
TC-G-1008
Atrogin-1,
SIRT1,
up-regulated
inhibiting
improving
The
beneficial
anti-atrophic
effects
are
diminished
following
treatment
SRT1720
RAPA.
Upon
knockout,
upregulated,
downregulated.
ZnSO₄-treated
group
remained
unchanged
(p
>
0.05),
indicating
that
supplementation
did
not
affect
ion
entry
acted
through
surface
receptor
GPR39.
ZnSO4
inhibits
excessive
skeletal
alleviates
via
GPR39-SIRT1/FoxO1
axis.
These
findings
suggest
may
offer
therapeutic
strategy
managing
Language: Английский
Apelin and Myostatin Levels in Adolescents With Type‐1‐Diabetes
Michal Cohen,
No information about this author
Lotem Weiss,
No information about this author
Ram Weiss
No information about this author
et al.
Pediatric Diabetes,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
Background:
Myokines
are
secreted
by
skeletal
muscle
and
play
a
role
in
their
metabolic
function
crosstalk
with
various
tissues.
appear
to
be
involved
the
pathogenesis
of
obesity
type
2
diabetes
(T2D),
yet
little
is
known
regarding
1
(T1D).
Aim:
To
assess
levels
clinical
correlates
panel
five
myokines,
comparing
adolescents
recent‐onset
T1D,
prolonged
disease,
healthy
controls.
Methods:
Fifty‐eight
participated;
20
over
7
years
18
controls
were
included.
Clinical
laboratory
data
collected,
including
Apelin,
Irisin,
Interleukin‐6
(IL‐6),
Fibroblast
growth
factor
21
(FGF21),
Myostatin.
Results:
Apelin
lower
patients
T1D
compared
controls,
(117.9
±
94.3,
228.3
181.6,
224.4
138.4
pg/ml,
respectively;
analysis
variance
(ANOVA)
p
=
0.029).
Other
myokines
did
not
differ
significantly
between
groups.
correlated
fasting
C‐peptide
(
r
0.337,
0.010).
In
myostatin
positively
insulin
doses
(total
daily
dose
0.590,
0.006
basal
0.645,
0.002).
Both
apelin
negatively
diastolic
blood
pressure
(BP)
percentile
−
0.324,
0.013;
0.302,
0.024,
respectively).
Conclusions:
Our
results
demonstrate
apelin,
myokine
related
beneficial
effects
muscle,
T1D.
The
correlations
may
reflect
relationship
beta‐cell
sensitivity.
Language: Английский
A PORTABLE BIOIMPEDANCE ANALYZER FOR REMOTE BODY COMPOSITION MONITORING: A CLINICAL INVESTIGATION UNDER CONTROLLED CONDITIONS
Nutrition,
Journal Year:
2024,
Volume and Issue:
126, P. 112537 - 112537
Published: July 20, 2024
In
an
era
when
telemedicine
is
becoming
increasingly
essential,
the
development
and
validation
of
miniaturized
Bioelectrical
Impedance
Analysis
(BIA)
devices
for
accurate
reliable
body
composition
assessment
crucial.
This
study
investigates
BIA
Metadieta,
a
novel
device,
by
comparing
its
performance
with
that
standard
hospital
equipment
across
diverse
demographic.
The
aim
to
enhance
remote
health
monitoring
integrating
compact
efficient
technology
into
routine
healthcare
practices.
Language: Английский
Identification of phase angle and Triglyceride-Glucose index as biomarkers for prediction and management of diabetic foot disease
Esther Soler-Climent,
No information about this author
L Lledó Rico,
No information about this author
MICHAEL POBLET
No information about this author
et al.
Metabolism Open,
Journal Year:
2024,
Volume and Issue:
23, P. 100315 - 100315
Published: Aug. 30, 2024
Approximately
25
%
of
diabetic
patients
develop
foot
ulcers
(DFUs),
significantly
increasing
morbidity,
mortality,
and
healthcare
costs.
Effective
control
prevention
are
crucial.
Language: Английский