Structural and Metabolic Changes in Pregnant Rat Uterine and Adipose Tissue Induced by a High-Fat High-Sugar Diet

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 446 - 446

Published: March 20, 2025

Pregnancy presents specific metabolic demands, and disruption caused by a high-fat high-sugar diet (HFHSD) have been associated with significant complications, including maternal health risk, fetal developmental issues, infertility. Obesity-related changes in the uterine tissues may contribute to these challenges. This study analyzed structural uterus adipose tissue of pregnant rats on gestation day 22 fed an HFHSD using various staining techniques. Hematoxylin eosin showed morphological structure, lumen size thickness myometrium, endometrium, perimetrium. The amount collagen was determined PicroSirius red staining, while PAS-D used observe glycogen content. Key protein expressions, such as insulin leptin receptors UCP1 UCP3, were immunohistochemistry. promoted hypertrophy visceral gonadal adipocytes, suggesting alterations. By end pregnancy, reduction observed. Additionally, decrease higher receptor expressions myometrium indicated physiological alteration. These findings offer insight into how affects structure function during late pregnancy but should be interpreted within context gestation-related changes. Further research is needed understand functional consequences alterations reproductive health.

Language: Английский

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Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 807 - 807

Published: March 12, 2024

Uterine fibroids (UFs) are the most common prevalent benign tumor among women of reproductive age, disproportionately affecting color. This paper introduces an innovative management strategy for UFs, emphasizing curbing disease prevention and progression. Traditionally, medical intervention is deferred until advanced stages, necessitating invasive surgeries such as hysterectomy or myomectomy, leading to high recurrence rates increased healthcare costs. The strategy, outlined in this review, emphasizes UF named LIFE UP awareness—standing Lifestyle Interventions, Food Modifications, Environmental Practices Prevention. These cost-effective, safe, accessible measures hold potential prevent improve overall health, reduce need procedures, generate substantial cost savings both individuals systems. review underscores importance a proactive method, paving way future research policy initiatives domain.

Language: Английский

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Advancements and Emerging Therapies in the Medical Management of Uterine Fibroids: A Comprehensive Scoping Review

Medical Science Monitor, Journal Year: 2024, Volume and Issue: 30

Published: April 18, 2024

Uterine fibroids, benign tumors originating from uterine smooth muscle cells, vary in prevalence depending on patient ethnicity, hormonal exposure, and genetics. Due to their high incidence, these neoplasms pose a significant burden healthcare systems. Current treatment strategies range routine monitoring asymptomatic cases surgical procedures such as myomectomy or hysterectomy symptomatic patients, with an increasing trend toward uterus-preserving non-surgical alternatives. This review examines the existing medical treatments for fibroids delves into potential of emerging therapies. A scoping literature was conducted accordance Preferred Reporting Items Systematic Reviews Meta-Analyses extension Scoping Reviews. Medical therapies are divided non-hormonal treatments; however, long-term, safe, effective limited. In addition established therapies, there is number studies investigating effect substances vitamin D green tea extract fibroids. Some investigate acupuncture possible alternative therapy. While offer relief preparation surgery, our findings point need further research long-term solutions, especially owing recent limitations use ulipristal acetate due risk liver damage. Initial involving epigallocatechin gallate encouraging; additional required establish definitive therapeutic roles.

Language: Английский

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Miomas bajo control: nutrición y ejercicios en acción

Revista Digital Universitaria, Journal Year: 2024, Volume and Issue: 25(4)

Published: June 28, 2024

Los miomas son crecimientos no cancerosos que se desarrollan en la pared del útero. Estos deben a múltiples factores, incluyendo dieta y actividad física. Las mujeres tienen pueden tener mayor sangrado menstrual, cólicos intensos, ciclos irregulares, dificultades para lograr el embarazo o riesgo durante éste. síntomas disminuyen calidad de vida las los padecen. Por ello, es importante su prevención tratamiento través Una alimentación alta frutas verduras, cuales ricas vitaminas, minerales, fibras antioxidantes, así como consumo algunos lácteos contienen calcio vitamina A ayudar evitar presencia miomas. De igual manera, suplementación con D puede ser gran ayuda disminuir tamaño, crecimiento aparición. Además, realizar física varios días semana contrario, carnes rojas procesadas implicar un presentar estos fibromas uterinos.

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