Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062

Published: Aug. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Language: Английский

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Gut microbial metabolism in Alzheimer's disease and related dementias

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(6), P. e00470 - e00470

Published: Oct. 1, 2024

Multiple studies over the last decade have established that Alzheimer's disease and related dementias (ADRD) are associated with changes in gut microbiome. These alterations organismal composition result abundances of functions encoded by microbial community, including metabolic capabilities, which likely impact host mechanisms. Gut microbes access dietary components other molecules made produce metabolites can enter circulation cross blood-brain barrier (BBB). In recent years, several been or shown to influence pathways relevant ADRD pathology. include short chain fatty acids, secondary bile tryptophan derivatives (such as kynurenine, serotonin, tryptamine, indoles), trimethylamine/trimethylamine N-oxide. Notably, some these BBB various effects on brain, modulating release neurotransmitters neuronal function, inducing oxidative stress inflammation, impacting synaptic function. Microbial also central nervous system through immune, enteroendocrine, enteric pathways, perturbations turn function peripheral immune responses, well integrity, homeostasis neurogenesis, glial cell maturation activation. This review examines evidence supporting notion is influenced microbiota its metabolites. The potential therapeutic advantages for preventing treating discussed, highlighting their role developing new treatments.

Language: Английский

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Safety Assessment and Probiotic Potential Comparison of Bifidobacterium longum subsp. infantis BLI-02, Lactobacillus plantarum LPL28, Lactobacillus acidophilus TYCA06, and Lactobacillus paracasei ET-66

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 126 - 126

Published: Dec. 29, 2023

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Language: Английский

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Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 29, 2025

Introduction The multi-targeted ligands (MTDL) strategy has been recognized as a promising Approach for the development of effective treatments against Alzheimer’s disease (AD), due to presence multiple pathological mechanisms in AD. In this study, series bis(7)-harmine derivatives were designed and synthesized multifunctional drugs treatment Methods by chemical methods their structure was confirmed nuclear magnetic resonance (NMR). Ellman’s assay utilized assess inhibitory potential h AChE BuChE. activity these on both MAO-A MAO-B assessed using fluorescence-based method. thioflavin T (Th-T) fluorescence used inhibition A β 1−42 self-aggregation. cytotoxicity evaluated MTT assay. Surflex-Dock program Sybyl-X2.0 Software employed molecular docking. Results vitro studies revealed that numerous compounds exhibited potent AChE, (IC 50 < 1 μM), well aggregation 20 μM). Importantly, multitarget 6d , 8c 8d remarkable efficacy simultaneously mitigating -induced toxicity SH−SY5Y cells while demonstrating minimal cytotoxicity. Furthermore, predicted ADMET results suggested possessed favorable pharmacokinetic properties demonstrated low levels. Additionally, docking within activesites MAO-B, elucidated mechanism. Discussion conclusion Based findings, it is evident hold multi-functional AD treatment.

Language: Английский

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Linkage of circadian rhythm disruptions with Alzheimer’s disease and therapeutic interventions

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Exploring Innovative Approaches for Managing Spinal Cord Injury: A Comprehensive Review of Promising Probiotics and Postbiotics

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

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Supplementation and Mitigating Cognitive Decline in Older Adults With or Without Mild Cognitive Impairment or Dementia: A Systematic Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3567 - 3567

Published: Oct. 21, 2024

This systematic literature review aims to answer the question of how micronutrients might influence development and progression dementia. In present work, we focused on an overview updated relevant published in last two decades. delineate relationship between micronutrient supplementation cognitive decline older subjects. carrying out this review, followed PRISMA, our search was performed PubMed. includes only primary studies that have investigated efficacy nutritional interventions for prevention dementia improvement function subjects aged 65 years or with normal cognition, mild impairment (MCI), Alzheimer's disease (AD). A gross heterogeneity forbids possibility a direct comparison results. inclusion criteria restrictions has been conducted check validity reliability thirty-three were included. Results shown vitamin D, probiotics, PUFAs would most likely reduce decline, dementia, AD compared vitamins A, B, C, E, which seen be relatively ineffective. Of note, when considering B supplementation, positive effects observed non-aspirin users having high ω-3 fatty acid (ω-3 FA) plasma levels. some cases, however, there genotypic differences response supplementation.

Language: Английский

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Effects of Probiotics on Markers of Oxidative/Nitrosative Stress and Damage Associated with Inflammation in Non-Communicable Diseases: a Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Inflammation and oxidative/nitrosative stress (O&NS) are serious complications in non-communicable diseases (NCDs), including endocrine & metabolic neurodegenerative diseases. The beneficial probiotic microbes, such as Lactobacillus, Bifidobacterium Streptococcus, can decrease O&NS inflammation. We conducted this systematic review meta-analysis of randomized controlled trials (RCTs) to elucidate the effects probiotics on inflammation NCDs. A search PubMed, Scopus EMBASE resulted inclusion studies if they met eligibility criteria. Methodological quality was assessed using Cochrane Risk Bias 2 tool. Data (combined effect size) were analyzed Meta Essentials software. Fifteen studies/16 with a total 837 participants reviewed. There high moderate certainty evidence (GRADE) for effectiveness intervention (vs. placebo) increasing (↑) glutathione (GSH) levels [SMD(SE) = 0.89 (0.51)/p < 0.05, 95%CI -0.23 2.1, I² 92.77%] antioxidant capacity (TAC) 0. 75 (0.22)/p 0.01, 0.28 1.23, 87.50%] well decreased (↓) malondialdehyde (MDA) (SMD(SE) 1.03 (0.31)/p 01, 0.37 1.7, 93.88%) C-reactive protein (hsCRP) 0.74 (0.36)/p -0.07 1.55, 94.32%). no nitric oxide, 8-hydroxy-2′-deoxyguanosine, interleukin-6, tumor necrosis factor-α. Subgroup analysis reduce heterogeneity indicated strain number (one/↑GSH), age bracket (41–60 year./↓MDA or > 61 year./↓hsCRP) NCD (nervous system/neurodegenerative diseases/↑GSH ↓hsCRP rheumatoid arthritis/polycystic ovary syndrome/↑TAC). An overall low risk bias observed. In conclusion, may have markers patients

Language: Английский

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The impact of probiotics therapy on cognitive and metabolic characteristics in patients with cognitive impairment: An umbrella review of meta-analysis of randomized controlled trials

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177326 - 177326

Published: Feb. 1, 2025

While existing meta-analysis suggest that probiotic therapies may enhance cognitive functions and influence metabolic characteristics, the findings have been inconclusive. In light of these discrepancies, our study undertakes an umbrella review to more precisely determine aggregate effects rigorously evaluate credibility quality evidence. We conducted a systematic search across seven databases, including PubMed, Embase, Cochrane Library, ProQuest, Web Science, CINAHL, Scopus, from their inception June 20, 2024. utilized AMSTAR-2 tool meta-analyses applied GRADE system rate estimated final effect sizes (ES) along with 95% confidence intervals (CI) performed both sensitivity subgroup analyses explore sources heterogeneity. Among 314 articles identified in search, 13 met criteria were included study. The evidence studies was graded high very low. Our results demonstrate treatment significantly enhances function patients (ESSMD = 0.39, 95%CI: 0.19 0.59, p<0.001). Moreover, notably decreased level serum malondialdehyde (MDA), insulin resistance as detected by homeostasis model assessment method (HOMA-IR) high-sensitivity C-reactive protein (hs-CRP) (p<0.001). Conversely, did not impact triglycerides very-low-density lipoprotein (VLDL) (p>0.05). Although preliminary indicated therapy positively function, MDA, HOMA-IR, hs-CRP, overall is insufficient provide strong support. Therefore, future research must employ rigorous designs or initiate larger clinical trials produce compelling further validate efficacy on dysfunction.

Language: Английский

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Mitigating seizure-induced cognitive deficits in mice induced with pentylenetetrazol by roflumilast through targeting the NLRP3 inflammasome/BDNF/SIRT3 pathway and regulating ferroptosis

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123488 - 123488

Published: Feb. 1, 2025

Language: Английский

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