Associations between perfluoroalkyl substance exposure and lean body mass in US adults: evidence from the NHANES 2015–2018 DOI

Xiao-huan Song,

Shuting Chen, Fei Jiang

et al.

Human and Ecological Risk Assessment An International Journal, Journal Year: 2024, Volume and Issue: 30(7-8), P. 662 - 679

Published: Aug. 28, 2024

Perfluoroalkyl substances (PFAS) are widely used in consumer and industrial products, their adverse effects have been studied extensively. However, associations between PFAS lean body mass (LBM) remain unclear. We examined cross-sectional among 1340 adults, aged 20–60 years, who participated the 2015–2018 National Health Nutrition Examination Survey (NHANES). Serum concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic (PFNA), (PFDA), perfluorooctane sulfonic (PFOS), perfluorohexane (PFHxS) had higher detection rates. They were to correlate with LBM humans. Effect modifications by sex index (BMI) also evaluated. Restricted cubic spline (RCS) modeling was examine dose-response outcomes. found that decreased 5.87 kg (95% CI: −7.58, −4.16), 3.14 −4.02, −2.25), 2.60 −3.42, −1.78) highest quartile PFDA serum concentration, respectively, relative weight lowest (trend p < 0.001). 2.27 −3.89, −0.65), 1.42 −2.26, −0.58), 0.79 −1.57, −0.02) PFOS concentration groups, respectively (all trend 0.05). The association consistently stronger females than males. RCS further confirmed negatively associated LBM.

Language: Английский

Reciprocal and Differential Influences of Mediterranean Diet and Physical Activity on Adiposity in a Cohort of Young and Older than 40 Years Adults DOI Open Access
Andrea Higuera‐Gómez, Begoña de Cuevillas, Rosa Ribot-Rodríguez

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1777 - 1777

Published: June 5, 2024

Translational research has documented the conjoint beneficial relationships between dietary and physical activity habits concerning weight maintenance. However, precise interplay diet exercise impacting body composition remains unclear, challenging personalized interventions. This study aimed to explore potential interactions effect modifications of these factors affecting mass index (BMI) within an online adult cohort. Data from 11,883 NUTRiMDEA cohort participants were analyzed in this cross-sectional study, categorizing individuals by age, sex, BMI using linear regression models assess lifestyle adiposity. Significant differences emerged anthropometry, lifestyle, health-related quality life (HRQoL) across categories. The combined had a greater impact on than or Mediterranean adherence alone, with lower as levels increased (β: −0.5) decreased, where modification them was identified −0.28). Participants displayed superior when low, but higher, their aligned those healthier habits. An interaction link found, showing differential effects combination

Language: Английский

Citations

2
Associations between perfluoroalkyl substance exposure and lean body mass in US adults: evidence from the NHANES 2015–2018 DOI

Xiao-huan Song,

Shuting Chen, Fei Jiang

et al.

Human and Ecological Risk Assessment An International Journal, Journal Year: 2024, Volume and Issue: 30(7-8), P. 662 - 679

Published: Aug. 28, 2024

Perfluoroalkyl substances (PFAS) are widely used in consumer and industrial products, their adverse effects have been studied extensively. However, associations between PFAS lean body mass (LBM) remain unclear. We examined cross-sectional among 1340 adults, aged 20–60 years, who participated the 2015–2018 National Health Nutrition Examination Survey (NHANES). Serum concentrations of perfluorooctanoic acid (PFOA), perfluorononanoic (PFNA), (PFDA), perfluorooctane sulfonic (PFOS), perfluorohexane (PFHxS) had higher detection rates. They were to correlate with LBM humans. Effect modifications by sex index (BMI) also evaluated. Restricted cubic spline (RCS) modeling was examine dose-response outcomes. found that decreased 5.87 kg (95% CI: −7.58, −4.16), 3.14 −4.02, −2.25), 2.60 −3.42, −1.78) highest quartile PFDA serum concentration, respectively, relative weight lowest (trend p < 0.001). 2.27 −3.89, −0.65), 1.42 −2.26, −0.58), 0.79 −1.57, −0.02) PFOS concentration groups, respectively (all trend 0.05). The association consistently stronger females than males. RCS further confirmed negatively associated LBM.

Language: Английский

Citations

0