Risk of Incident Type 2 Diabetes and Prediabetes in Patients With Direct Acting Antiviral‐Induced Cure of Hepatitis C Virus Infection

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

ABSTRACT Background Data regarding the risk of incident type 2 diabetes (T2D) and prediabetes among patients with hepatitis C virus (HCV) achieving direct‐acting antivirals (DAAs)‐induced sustained virologic response (SVR 12 ) remains limited. Methods A total 1079 patients, including 589 normoglycemia 490 prediabetes, who underwent biannual fasting glucose glycosylated haemoglobin (HbA1c) assessment for a median post‐SVR follow‐up 5.5 years, were enrolled. We reported crude (cIRs) age‐standardised incidence rates (ASIRs) T2D prediabetes. Factors associated assessed using Cox proportional hazards models. Results The cIRs 1.18 8.99 per 100 person‐years (PYFU), respectively. Additionally, ASIRs 1.09 (95% CI: 0.76–1.53) 8.47 7.23–9.90) PYFU. Prediabetes (adjusted hazard ratio [aHR]: 4.71; 95% confidence interval (CI): 2.55–8.70, p < 0.001), body mass index (BMI) kg/m increase (aHR: 1.17; 1.09–1.26, 0.001) liver stiffness measurement (LSM) kPa 1.05; 1.02–1.09, = higher T2D. Age year 1.02; 1.01–1.03, was Conclusion remain substantial after HCV eradication. Lifestyle modification, drug therapy regular monitoring glycemic status are crucial at developing following clearance.

Language: Английский

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Role of Medical Nutrition Therapy as Treatment of Sarcopenia in Older People with Type 2 Diabetes

Nutrients, Journal Year: 2025, Volume and Issue: 17(1), P. 172 - 172

Published: Jan. 2, 2025

Background: Globally, the progressive increase in aging population has led to social and health problems associated with age-related chronic diseases, such as type 2 diabetes mellitus (T2DM) sarcopenia. Recent studies have highlighted that sarcopenia a bidirectional relationship. Nutritional therapy is key element treatment of both diabetes. To date, there are no nutritional guidelines for management T2DM. The aim this study was evaluate efficacy muscle-targeted intervention older people based on Italian nutrition guidelines. Methods: A total 211 subjects (117 M 94 F) affected by T2DM mean age 74 ± 6.0 years were screened sarcopenia, using EWGSOP2 diagnosis criteria, enrolled receive personalized dietary plans two main targets: daily energy intake 25–30 kcal/kg body weight protein at least 1.1–1.2 g/kg weight. Results: In total, 34 (24 10 sarcopenic prevalence 16%, which higher men. After six months treatment, handgrip strength increased 0.83 kg (19.57 5.70 vs. 20.40 6.10 kg, p = 0.649), improved (0.91 0.28 1.03 0.40 weight, 0.115), glycated hemoglobin decreased (7.39 0.49% 6.82 0.98%, 0.010). Seven younger had an improvement decrease HbA1c (7.50 0.59% 6.91 0.79, 0.19). difference over time consumption saturated fatty acids (OR 0.6, 95% CI 0.33–1.09, 0.096) simple sugars 0.91, 0.80–1.01, 0.090) appeared be status. 177 did not meet criteria 148 assessed. (26.22 9.36 26.18 9.24 p0.974) (7.21 1.07 7.27 0.735) remained stable time, while (0.81 0.29 0.91 0.024). Four diagnosed follow-up, lower test result. These worse glycemic control (HbA1c + 0.5%). Conclusions: Lifestyle modification important prevent or reverse development disease. therefore aimed meeting all needs promoting better control, terms hemoglobin, order reduce Although promising, requires validation larger groups.

Language: Английский

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Relationship Between Body Mass Index and Low Skeletal Muscle Mass in Adults Based on NHANES 2011–2018

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Sarcopenia, a syndrome characterized by declining muscle mass and function, is associated with various adverse health outcomes. While body index (BMI) fundamental indicator, its relationship sarcopenia complex remains inadequately explored. Low BMI has been linked to loss, but the role of other demographic clinical factors in this unclear. This cross-sectional study analyzed data from NHANES 2011–2018 cohort, including 7,455 adults aged ≥ 20 years. was diagnosed based on appendicular skeletal using DXA criteria. categorized into quartiles for analysis. Weighted multivariable logistic regression assessed associations between low mass, adjusting confounders such as age, gender, ethnicity, income-to-poverty ratio, chronic diseases (e.g., diabetes hypertension). Variance inflation (VIF) confirmed absence multicollinearity. Lower significantly higher odds (adjusted OR: 0.508, 95% CI: 0.483–0.533, p < 0.001), while exhibited protective effect. Age (OR: 1.035, 1.025–1.045, 0.001) female gender 1.570, 1.267–1.949, were independent risk factors. Racial disparities noted, non-Hispanic Black individuals at lower compared Whites 0.242, 0.152–0.384, 0.001). Other significant included alcohol consumption, education smoking status not associated. inversely prevalence, posing odds. The findings underscore importance monitoring addressing multifactorial profiles management prevention.

Language: Английский

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Aging and putative frailty biomarkers are altered by spaceflight

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 11, 2024

Human space exploration poses inherent risks to astronauts' health, leading molecular changes that can significantly impact their well-being. These alterations encompass genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and various epigenomic changes. Remarkably, these bear similarities those observed during the aging process on Earth. However, our understanding of connection between shifts disease development in remains limited. Frailty syndrome, a clinical syndrome associated with biological aging, has not been comprehensively investigated spaceflight. To bridge this knowledge gap, we leveraged murine data obtained from NASA's GeneLab, along astronaut gathered JAXA Inspiration4 missions. Our objective was assess presence markers pathways related frailty, sarcopenia within spaceflight context. Through analysis, identified notable gene expression patterns may be indicative frailty-like condition findings suggest parallels extend frailty as well. Consequently, further investigations exploring utility index monitoring health appear warranted.

Language: Английский

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Sarcopenia: A dive into metabolism to promote a multimodal, preventive, and regenerative approach

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 219, P. 111941 - 111941

Published: May 14, 2024

Sarcopenia, the age-related loss of skeletal muscle mass and function, poses a significant challenge in field gerontology, impacting health independence older adults. By synthesizing current research findings theoretical frameworks, this perspective elucidates multifaceted mechanisms underlying sarcopenia, mainly focusing on energy balance metabolic processes. Furthermore, manuscript explores implications sarcopenia overall outcomes, functional decline, quality life individuals.

Language: Английский

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Therapeutic potential of 4-hexylresorcinol in reducing sarcopenia in diabetic masseter muscle

Maxillofacial Plastic and Reconstructive Surgery, Journal Year: 2025, Volume and Issue: 47(1)

Published: Jan. 20, 2025

Abstract Background This study aimed to evaluate the effects of 4-hexylresorcinol (4HR), a synthetic compound with antioxidant and stress-modulating properties, on diabetic sarcopenia in masseter muscle. Methods A controlled, parallel-arm was conducted using 38 Sprague–Dawley rats divided into non-diabetic groups. Diabetes induced streptozotocin (STZ), groups were further subdivided receive weekly subcutaneous injections either 4HR or saline. Muscle volume assessed micro-computed tomography (μCT), glycogen storage protein expression analyzed periodic acid-Schiff (PAS) staining immunohistochemistry. Results μCT analysis revealed that exhibited significantly reduced muscle compared rats. However, treatment partially mitigated loss animals. Histological showed higher PAS intensity group treated untreated group, suggesting improved storage. Immunohistochemistry demonstrated increased Glut4 phosphorylated AMPKα (p-AMPKα) muscle, indicating enhanced glucose uptake metabolic activity. Conclusions effectively alleviates diabetes-induced by preserving volume, enhancing storage, upregulating p-AMPKα expression. These findings suggest holds potential as therapeutic agent for combating wasting diabetes.

Language: Английский

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Medical Nutrition Therapy and Physical Exercise for Acute and Chronic Hyperglycemic Patients with Sarcopenia

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 499 - 499

Published: Jan. 29, 2025

A wide range of factors contribute to the overlap hyperglycemia—acute or chronic—and sarcopenia, as well their associated adverse consequences, which can lead impaired physical function, reduced quality life, and increased mortality risk. These include malnutrition (both overnutrition undernutrition) low levels activity. Hyperglycemia sarcopenia are interconnected through a vicious cycle events that mutually reinforce worsen each other. To explore this association, our review compiles evidence on: (i) impact hyperglycemia on motor muscle with focus mechanisms underlying biochemical changes in muscles individuals at risk diabetes sarcopenia; (ii) importance clinical assessment control under hyperglycemic conditions; (iii) potential benefits medical nutrition therapy activity muscle-targeted treatments for population. Based reviewed evidence, we conclude regular intake key functional nutrients, together structured supervised resistance and/or aerobic activity, help maintain euglycemia improve status all patients sarcopenia.

Language: Английский

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Risk factors of stroke-related sarcopenia: a systematic review and meta-analysis

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 31, 2025

Background The presence of sarcopenia at the time stroke may deteriorate rehabilitation and functional outcomes. There is no consensus on factors associated with stroke-related because previous studies produced inconsistent disputed results. Therefore, we screened possible risk by meta-analysis. Methods Studies published before March 2024 were searched through PubMed, Embase, Web Science, CINAHL, Cochrane Library, CNKI, Wan Fang, CBM, VIP library databases. Two researchers independently articles to extract information evaluate their quality. Meta-analysis was then performed using Revman 5.4 software determine significant for patients sarcopenia. Results A total 14 (n = 3,113) selected following that statistically in sarcopenia: Age (OR 1.04; 95% CI: 1.02, 1.06; P &lt; 0.0001), tube feeding 3.98; 2.12, 7.47; pre-stroke 1.84; 1.39, 2.43; atrial fibrillation 1.53; 1.15, 2.02; 0.003), NIHSS score 1.48; 1.21, 1.81; osteoporosis 1.801; 58, 2.04; 0.00001). BMI ( 0.71), FOIS 0.80), since 0.34), calf circumference reduction 0.48) not identified as or protective after 0.05). Conclusion Our results various which should be considered studied healthcare organizations professionals improve health patients. Systematic Review Registration PROSPERO, Identifier CRD42024545757.

Language: Английский

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A nomogram to predict sarcopenia in middle-aged and older women: a nationally representative survey in China

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 5, 2025

Sarcopenia is a disease characterized by losing muscle mass, strength, and function with age. Studies have shown that sarcopenia generally higher in women than men. Therefore, this study used the 2015 China Health Retirement Longitudinal Study (CHARLS) data to explore further risk factors associated middle-aged older Chinese women. In study, from CHARLS database were analyzed, comprising 7,805 eligible participants. Participants categorized into either group (n = 2,160) or non-sarcopenia 5,645) based on presence absence of sarcopenia. Through utilization logistic regression analysis, multiple identified. Additionally, predictive value these was assessed applying receiver operating characteristic (ROC) curve analysis. Subsequently, visual nomogram prediction model developed incorporating identified R4.1.2 software. Age, area, education, marriage, waist circumference, stroke, body pain, depression, region may be closely related addition, integrated sarcopenia-related variables comprehensive index, ROC analysis results showed AUC composite index 0.738. This found age, waist, physical region. constructs help clinicians better screen potential female patients

Language: Английский

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Decreased muscle strength and thigh muscle area assessed with CT imaging in older Chinese adults with long duration of type 2 diabetes

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(4), P. 100506 - 100506

Published: Feb. 14, 2025

Language: Английский

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