Anti-Aging Effects of Flavonoids from Plant Extracts

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2441 - 2441

Published: Aug. 2, 2024

Aging is a natural and irreversible process, affecting living organisms by negatively impacting the tissues' cells' morphology functionality consequently being responsible for aging-related diseases. Taking into account actual preoccupations of both consumers researchers, healthy anti-aging alternatives are intensively studied in order to address such concerns. Due their functional features, plant flavonoids can be considered valuable nutraceuticals. This paper highlights possibilities use extracted from various plants potential on skin, brain, heart. Moreover, anticarcinogenic, anti-inflammatory, anti-diabetic properties summarized, along with senescence-associated mechanisms. Both nutraceutical cosmeceutical fields continuously developing originating promising candidates obtain products. Thus, bioactive compounds' extraction subsequent involvement innovative product manufacturing must carefully performed while aware intrinsic extrinsic factors that may affect phytochemicals' structures, bioavailability, health effects.

Language: Английский

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Associations of the Intake of Individual and Multiple Flavonoids with Metabolic Dysfunction Associated Steatotic Liver Disease in the United States

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 205 - 205

Published: Jan. 7, 2025

Evidence regarding the individual and combined impact of dietary flavonoids on risk metabolic dysfunction associated with steatotic liver disease (MASLD) remains scarce. Our objective is to evaluate association between multiple MASLD in adults. Data sets were obtained from National Health Nutrition Examination Survey (NHANES), 2017-2018. In total, 2581 participants aged over 18 years, complete information flavonoid intake, MASLD, covariates, included. Flavonoid intake was energy-adjusted using residual method. Logistic regression analysis employed examine total MASLD. Weighted quantile sum (WQS) analyses used effects identify predominant types most significant contribution prevention. The highest tertile a 29% reduction compared lowest after multivariable adjustments (OR: 0.71, 95% CI: 0.51-0.97). WQS revealed that anthocyanidins, flavones, flavanones critical contributors among six subclasses (weights = 0.317, 0.279, 0.227, respectively) naringenin, apigenin, delphinidin 29 monomers. 0.240, 0.231, 0.114, respectively). Also, higher linked reduced (p < 0.05). findings suggested lower flavanones, delphinidin, myricetin contributing protective flavonoids.

Language: Английский

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Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 349 - 349

Published: Jan. 19, 2025

Background: Knee osteoarthritis (OA) is a common and debilitating disorder marked by joint degradation, inflammation, persistent pain. This study examined the possible therapeutic effects of curcumin vitamin D on OA progression pain in rat knee model anterior cruciate ligament transection meniscectomy (ACLT + MMx). Methods: Male Wistar rats were categorized into five groups: control, curcumin-treated (100 mg/kg/day), D-treated (25 µg/kg/day), combination curcumin, sham-operated. All supplements administered orally daily basis for 12 weeks. Pain behaviors assessed, serum biomarkers measured, histology was examined. Results: Both independently reduced pain, while combined group exhibited better analgesic effects. Serum inflammatory cytokines demonstrated decrease pro-inflammatory an elevation anti-inflammatory cytokine interleukin-10 (IL-10) supplement groups. The antioxidative markers partially recovered supplement. However, oxidative stress marker Cartilage Oligomeric Matrix Protein (COMP) significantly reduced. Histology analysis revealed preservation architecture cartilage integrity decreased synovium inflammation groups treated with D. Conclusions: Our findings indicate dual mechanism that encompasses role anti-inflammation antioxidation reduction, underscoring potential these natural chemicals as agents OA; may be added delaying associated management clinical patient care.

Language: Английский

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Enrichment of major bioavailable molecule glucuronated flavone TMMG in Spinacia oleracea ameliorates cartilage degeneration at a lower dose in ACLT-induced osteoarthritis

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Spinacia oleracea extract with its primary molecule, the glucuronide flavone TMMG, at 10 mg kg −1 d , proved effective in counteracting damaging effects on cartilage induced by ACLT, improved motor activity and coordination.

Language: Английский

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Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 447 - 447

Published: Jan. 26, 2025

Background: Vitamin D is beneficial for musculoskeletal health. Although low levels of vitamin are linked to increased pain in knee osteoarthritis (OA), their association with functionality remains understudied. Objective: This study aimed investigate the between deficiency and functional status elderly individuals OA explore potential correlation plasma tumor necrosis factor alpha (TNF-α) interleukin-6 (IL-6). Methods: The included older adults (≥60 years) from an ageing study, encompassing 105 patients 152 controls. diagnosis was confirmed radiographically, WOMAC questionnaire assessed impairment these patients. Blood samples were collected measure 25(OH) by chemiluminescence TNF-α IL-6 ELISA. Results: Patients insufficiency/deficiency exhibited more severe cases compared those normal (p = 0.04). inversely correlated OA, according Index (global: rS −0.25, p 0.01; pain: −0.21, 0.03). Moreover, showed significantly higher < 0.05, Mann−Whitney test). Conclusions: Reduced associated hip osteoarthritis, pain, greater impairment, elevated serum IL-6. Further research required elucidate mechanisms underlying influence on evaluate benefits supplementation mitigating disease symptoms progression.

Language: Английский

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Impact of Whole-Body Vibration Therapy in Elderly Populations: A Scoping Review

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

The aging population faces neuromuscular stability, balance, and cardiovascular health challenges. This comes with a financial burden, morbidity, reduced quality of life. Whole-body vibration (WBV) is potential noninvasive therapy to address these review aimed determine document the extent WBV benefits in elderly, as reported literature. OVID, EMBASE, Web Science were searched for peer-reviewed articles written English between January 2008 November 2024. Included involving effects on hemodynamics, sarcopenia persons aged 50 older. initial search yielded 467 articles, 37 included final review. increased skin blood flow improved markers endothelial cell function. Mixed results exist arterial stiffness metrics, there was no significant impact pressure. most promising evidence relates sarcopenia, where improvements muscle strength, performance, functionality. Elderly osteoarthritis had similar results, addition pain stiffness. Patients Parkinson's disease have tremor, rigidity, postural stability. In contrast, stroke patients mixed activation but showed improvement ankle joint proprioception. We conclude that although some supporting heart rate, function, stiffness, contradictory findings are reported. points need further research better definition optimal dosage WBV, including its amplitude frequency.

Language: Английский

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Cathepsin K Inhibitors as Potential Drugs for the Treatment of Osteoarthritis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2896 - 2896

Published: March 22, 2025

Links between cathepsin K and the pathophysiology of osteoarthritis (OA) can be established, not least because overabundance in serum OA patients upregulation degraded cartilage animal models OA. Chondrocytes, chondroclasts, or osteoclasts contribute to accumulated at diseased osteochondral junction. After a general presentation physiology, as well its degradation processes, we describe function effect on via type II collagen cleavage. An overview most promising inhibitors is then presented, together with their vitro effects. Although intensive research initially focused bone resorption, there growing interest potential these drugs prevent degradation. In this review, summarize pre-clinical clinical trials that support use treatment To date, no molecules are commercially available, although few have undergone trials, but believe development could broaden therapeutic arsenal for

Language: Английский

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Effectiveness and safety of steamed ginger extract on mild osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The purpose of this study was to evaluate the efficacy and safety steamed ginger extract (GGE03) in subjects with mild knee osteoarthritis (OA). In total, 100 were randomly assigned (1 : 1) GGE03 (0.48 g day

Language: Английский

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New Nanovesicles from Prickly Pear Fruit Juice: A Resource with Antioxidant, Anti-Inflammatory, and Nutrigenomic Properties

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1756 - 1756

Published: Oct. 23, 2024

Plant-derived nanovesicles represent a novel approach in the field of plant-derived biomaterials, offering sustainable and biocompatible option for various biomedical applications. The unique properties these vesicles, such as their ability to encapsulate bioactive compounds, make them suitable therapeutic, cosmetic, nutraceutical purposes. In this study, we have, first time, successfully bio-fabricated vesicles derived from Opuntia ficus-indica (FicoVes) using an efficient cost-effective method. Characterized by size approximately 114 nm negative zeta potential -20.9 mV, FicoVes exhibited excellent biocompatibility hemocompatibility, showing no reduction viability human animal cells. Our results showed that possess significant antioxidant they reduced ROS generation TBH-stimulated displayed anti-inflammatory reducing expression pro-inflammatory cytokines (Il 1β, TNF α) enhancing (IL4, IL10) following inflammatory stimulus. Furthermore, accelerated epithelial wound closure L929 fibroblast monolayers dose-dependent manner, highlighting role tissue repair. This study establishes promising candidate nutrigenomic applications, particularly context inflammation-related disorders healing. Further research, including vivo studies, is essential validate findings fully explore therapeutic potential.

Language: Английский

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Autophagy and nutrigenomics: a winning team against chronic disease and tumors

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 5, 2024

Autophagy, a vital cell process, has garnered attention for its role in various diseases and potential therapeutic interventions. Dysregulation of autophagy contributes to conditions such as metabolic diseases, neurodegenerative disorders, cancer. In diabetes, plays crucial islet β-cell maintenance glucose homeostasis, offering targets intervention. Nutrigenomics, which explores how dietary components interact with the genome, emerged promising avenue disease management. It sheds light on diet influences gene expression cellular processes, personalized approaches prevention Studies have showed impact specific components, polyphenols omega-3 fatty acids, suggesting their benefits disorders. cancer, autophagy's dual either suppressing tumorigenesis or promoting cancer survival underscores importance understanding modulation through Combined conventional chemotherapy drugs, compounds show synergistic effects treatment. Furthermore, phytochemicals indicaxanthin been found epigenetically regulate genes involved autophagy, novel insights into therapies. This comprehensive review aim study combined view nutrigenomics some molecules maintaining homeostasis responding pathological stimuli. Overall, intersection effect bioactive holds promise developing targeted interventions emphasizing significance

Language: Английский

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