Vitamin D and Endometriosis: Is There a Mechanistic Link? DOI Creative Commons

Bethany Scout Jennings,

Martin Hewison

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 43(1)

Published: Dec. 31, 2024

Endometriosis is a prevalent chronic gynaecological disorder, but its cause still unclear, and both genetic environmental factors may contribute disease aetiology. Prominent amongst the latter vitamin D which can be obtained either by action of sunlight on skin or from dietary sources. Serum levels main circulating form D, 25-hydroxvitamin (25(OH)D), have been reported to inversely correlated with endometriosis, suggesting that D-deficiency risk factor for disease. Crucially, active 1,25-dihydroxyvitamin (1,25(OH)

Language: Английский

Association between dietary vitamin B6 intake and endometriosis risk: evidence from the national health and nutrition examination survey DOI Creative Commons
Ling Yin, Liang Feng, Baoli Xie

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 3, 2024

Endometriosis is a multifaceted disorder with genetic, immune, inflammatory, and multifactorial origins. Vitamin B6 serves as pivotal coenzyme in various metabolic pathways involving lipids, hemes, nucleic acids, proteins, carbohydrates. Dysregulation or deficiency of vitamin can perturb human physiology. However, the relationship between dietary endometriosis remains elusive. This study aims to explore how intake associated risk endometriosis.

Language: Английский

Citations

0

A cross-sectional study on the relationship between dietary fiber and endometriosis risk based on NHANES 1999–2006 DOI Creative Commons

Ya-Fang Zheng,

Yu-Miao Guo,

Chunlang Song

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 18, 2024

Endometriosis is a chronic inflammatory disease and an estrogen-dependent disease, so dietary factors that can modulate estrogen activity may be clinically important. Dietary fiber, widely distributed in vegetables fruits, closely associated with plant-based diet. Therefore, this study aims to analyze explore the relationship between fiber intake risk of endometriosis providing insights for future clinical significance treatment approaches. This cross-sectional obtained data from National Health Nutrition Examination Survey (NHANES) 1999–2006 women aged 20–54 years. A total 2840 subjects were finally included analysis, 2599 (91.51%) non-endometriosis group 241 (8.49%) group. The used fibre as exposure variable outcome variable. Through use multiple regression modelling, subgroup analyses, smoothed curve fitting, threshold effect tests, we uncovered significant link outcome. In Model 2 (Multiple equation model after adjusting all confounding variables), confounders, was negatively likelihood developing endometriosis(OR = 0.588, 95% CI 0.360–0.959, p 0.041). analyses stratified by age, race, BMI, educational level, hypertension, diabetes,and hyperlipidemia, interactions visualised fitted curves. study, connection observed higher decreased endometriosis.

Language: Английский

Citations

0

Vitamin D and Endometriosis: Is There a Mechanistic Link? DOI Creative Commons

Bethany Scout Jennings,

Martin Hewison

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 43(1)

Published: Dec. 31, 2024

Endometriosis is a prevalent chronic gynaecological disorder, but its cause still unclear, and both genetic environmental factors may contribute disease aetiology. Prominent amongst the latter vitamin D which can be obtained either by action of sunlight on skin or from dietary sources. Serum levels main circulating form D, 25-hydroxvitamin (25(OH)D), have been reported to inversely correlated with endometriosis, suggesting that D-deficiency risk factor for disease. Crucially, active 1,25-dihydroxyvitamin (1,25(OH)

Language: Английский

Citations

0