No evidence of genetic causation between iron and infertility: a Mendelian randomization study DOI Creative Commons

Liangliang Guo,

Shengnan Yin,

Hongkui Wei

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 22, 2024

Background Observational studies have explored the impact of iron homeostasis on infertility; however, establishing definitive causal relationships remains challenging. This study utilized a two-sample Mendelian randomization approach to investigate potential relationship between status and infertility. Materials methods Four indicators status-serum iron, ferritin, transferrin saturation, total binding capacity, were considered as exposure factors. Infertility was outcome variable for both men women. Robust causality assessed using primary inverse-variance-weighted method, complemented by three supplementary approaches. Sensitivity analyses performed enhance precision reliability results. Results No statistically significant associations identified four These results remained consistent across multiple methodologies. Conclusion In conclusion, there is no evidence genetic Nevertheless, this does not preclude possibility connection infertility at different mechanistic levels.

Language: Английский

Electromagnetic fields regulate iron metabolism: From mechanisms to applications DOI Creative Commons

Shenghang Wang,

Jiancheng Yang,

Chenxiao Zhen

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Electromagnetic fields (EMFs), as a form of physical therapy, have been widely applied in biomedicine. Iron, the most abundant trace metal living organisms, plays critical role various physiological processes, and imbalances its metabolism are closely associated with development progression numerous diseases. Numerous studies demonstrated that EMF exposureinduces significant changes both systemic cellular iron metabolism. This review aims to summarize evidence potential biophysical mechanisms underlying EMFs regulating metabolism, thereby enhancing understanding their biological expanding applications biomedical fields. In this review, we synthesized research findings proposed hypothesis regulate involve special electromagnetic properties iron-containing proteins iron-enriched tissues, well modulation membrane structure function, ion channels, generation activity Reactive Oxygen Species (ROS). Then, summarizes latest advances effects on safety, impact immunoregulation, cardiovascular diseases, neurological orthopedic diabetes, liver injury, cancer.

Language: Английский

Citations

0
Sex-specific associations between exposure to metal mixtures and mitochondrial DNA copy number: A repeated-measures study DOI

Junxiu He,

Xiaoting Ge,

Sencai Lin

et al.

Journal of Environmental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
No evidence of genetic causation between iron and infertility: a Mendelian randomization study DOI Creative Commons

Liangliang Guo,

Shengnan Yin,

Hongkui Wei

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 22, 2024

Background Observational studies have explored the impact of iron homeostasis on infertility; however, establishing definitive causal relationships remains challenging. This study utilized a two-sample Mendelian randomization approach to investigate potential relationship between status and infertility. Materials methods Four indicators status-serum iron, ferritin, transferrin saturation, total binding capacity, were considered as exposure factors. Infertility was outcome variable for both men women. Robust causality assessed using primary inverse-variance-weighted method, complemented by three supplementary approaches. Sensitivity analyses performed enhance precision reliability results. Results No statistically significant associations identified four These results remained consistent across multiple methodologies. Conclusion In conclusion, there is no evidence genetic Nevertheless, this does not preclude possibility connection infertility at different mechanistic levels.

Language: Английский

Citations

2