Progress in molecular biology and translational science, Journal Year: 2024, Volume and Issue: unknown, P. 185 - 209
Published: Jan. 1, 2024
Language: Английский
Life, Journal Year: 2025, Volume and Issue: 15(1), P. 126 - 126
Published: Jan. 18, 2025
Post-translational modifications (PTMs) of proteins dynamically build the buffering and adapting interface between oncogenic mutations environmental stressors, on one hand, cancer cell structure, functioning, behavior. Aberrant PTMs can be considered as enabling characteristics long they orchestrate all malignant variability in proteome cells, cancer-associated tumor microenvironment (TME). On other enhance anticancer mechanisms tumoral ecosystem or sustain beneficial effects oncologic therapies through degradation inactivation carcinogenic or/and activation tumor-suppressor proteins. In this review, we summarized analyzed a wide spectrum involved regulatory that drive tumorigenesis, genetic instability, epigenetic reprogramming, events metastatic cascade, cytoskeleton extracellular matrix (ECM) remodeling, angiogenesis, immune response, tumor-associated microbiome, metabolism rewiring most important hallmarks cancer. All develop due to proteins, which modulate gene transcription, intracellular signaling, protein size, activity, stability localization, trafficking, secretion, half-life, protein–protein interactions (PPIs). associated with exploited better understand underlying molecular heterogeneous chameleonic disease, find new biomarkers progression prognosis, personalize oncotherapies, discover targets for drug development.
Language: Английский
Citations
2
Cancer Letters, Journal Year: 2024, Volume and Issue: 605, P. 217297 - 217297
Published: Oct. 16, 2024
Language: Английский
Citations
5
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 19, 2025
The NLRP3 inflammasome and NF-κB signaling pathways play crucial roles in orchestrating inflammation immune defense. This review explores the intricate relationship between these epigenetic regulation, a field of growing importance understanding responses. Epigenetic modifications, including DNA methylation, histone non-coding RNAs (ncRNAs), significantly influence activity genes involved pathways, thereby modulating inflammatory provides comprehensive overview current research on how mechanisms interact with regulate pathways. It delves into advanced concepts such as RNA modifications 3D genome organization, their impact regulation. Furthermore, implications findings for developing novel therapeutic strategies targeting regulators diseases are discussed. By synthesizing recent advancements this rapidly evolving field, underscores critical role regulation highlights potential epigenetic-based therapies treating wide range conditions, autoimmune disorders cancer.
Language: Английский
Citations
0
Progress in molecular biology and translational science, Journal Year: 2024, Volume and Issue: unknown, P. 185 - 209
Published: Jan. 1, 2024
Language: Английский
Citations
0