The role of low glycemic index and load diets in medical nutrition therapy for type 2 diabetes: an update
Eleni Gerontiti,
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Almog Shalit,
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Katerina Stefanaki
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et al.
HORMONES,
Journal Year:
2024,
Volume and Issue:
23(4), P. 655 - 665
Published: May 16, 2024
The
increasing
prevalence
of
type
2
diabetes
mellitus
(T2DM)
and
its
microvascular
macrovascular
complications
necessitate
an
optimal
approach
to
prevention
management.
Medical
nutrition
therapy
serves
as
the
cornerstone
care,
reducing
reliance
on
diabetic
medications
for
glycemic
control
mitigating
cardiovascular
risk.
broadening
field
research
in
effect
low
index
(GI)
and/or
load
(GL)
diets
individuals
with
T2DM
has
yielded
promising
results
existing
literature.
Adopting
low-GI
GL
dietary
patterns
contributes
minimizing
fluctuations
blood
glucose
levels,
thus
presenting
a
good
strategy
achieving
enhanced
control.
Furthermore,
above
practices
may
offer
viable
alternative
practical
weight
management
T2DM.
However,
clinical
practice
guidelines
show
inconsistency
regarding
certainty
evidence
supporting
implementation
low-GI/GL
nutritional
patterns.
This
review
aims
thoroughly
evaluate
available
data
effectiveness
low-GL
managing
risk
factors.
Language: Английский
Impact of Maternal Macronutrient Intake on Large for Gestational Age Neonates’ Risk Among Women with Gestational Diabetes Mellitus: Results from the Greek BORN2020 Cohort
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 269 - 269
Published: Jan. 13, 2025
Background/Objectives:
The
effect
of
maternal
macronutrient
composition
on
the
risk
large
for
gestational
age
(LGA)
neonates
among
women
with
diabetes
mellitus
(GDM)
is
not
well
understood.
This
study
aimed
to
investigate
these
associations
in
a
pregnant
cohort
Northern
Greece,
considering
both
pre-pregnancy
and
early
pregnancy
dietary
intake,
stratifying
by
body
mass
index
(BMI).
Methods:
From
total
797
eligible
women,
117
(14.7%)
who
developed
GDM
(and
thus
were
included
study)
completed
validated
Food
Frequency
Questionnaires
(FFQs).
Macronutrient
intake
was
assessed
six
months
before
until
mid-gestation,
prior
oral
glucose
tolerance
test.
Data
compared
European
Safety
Authority
(EFSA)
guidelines,
participants
stratified
BMI
(normal
vs.
overweight/obese).
Multivariate
logistic
regression
used
estimate
adjusted
odds
ratios
(aORs)
LGA
risk.
Results:
In
normal-BMI
GDM,
higher
fiber
(aOR
=
1.39)
vegetable
protein
1.61)
significantly
associated
an
increased
LGA.
During
pregnancy,
elevated
from
persisted
1.51).
Among
overweight/obese
no
significant
observed.
However,
during
percentage
carbohydrate
linked
1.11),
while
maintaining
saturated
fatty
acids
“as
low
as
possible”
reduced
0.71).
Elevated
also
1.61).
Conclusions:
Maternal
may
influence
distinct
patterns
according
BMI.
These
findings
underscore
importance
tailoring
recommendations—especially
regarding
fiber,
protein,
carbohydrates,
fat—to
mitigate
GDM.
Language: Английский
Associations Between Carbohydrate Intake Behaviours and Glycaemia in Gestational Diabetes: A Prospective Observational Study
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(3), P. 400 - 400
Published: Jan. 22, 2025
Carbohydrate
intake
(CI)
has
the
largest
impact
on
short-term
glycaemia
of
all
nutrients,
yet
optimal
CI
management
in
gestational
diabetes
remains
unclear.
Objective:
To
examine
behaviours
individuals
with
recently
diagnosed
and
their
association
self-monitored
blood
glucose.
Methods:
Data
from
97
were
collected
using
food
glucose
diaries.
(including
amounts,
types,
timing)
was
manually
assessed
15
g
servings
over
5–8
days,
while
a
3-day
computerised
analysis
examined
broader
macro-
micronutrients.
Results:
Elevated
fasting
(EFG)
associated
lower
total
(Mdn
10.8
vs.
12.5
servings/day,
p
=
0.006),
missed
meals
1.4
0.0/week,
0.007),
snacks
10.5
7.5/week,
0.038),
low-carbohydrate
(<30
g;
Mdn
4.3
2.0/week,
0.004),
higher
proportion
energy
fat
35%
33%,
0.047),
as
compared
in-target
glycaemia.
In
contrast,
elevated
postprandial
(EPG)
not
significantly
CI,
g),
(<15
or
high-carbohydrate
loads
(>50
g).
EPG
instead
high-glycaemic
index
1.6
0.9
lunch
meals/week,
0.026;
0.0
dinner
0.023);
7650
kJ
9070
kJ/day,
0.031),
protein
91
109
g/day,
0.015),
61
84
0.003),
multiple
micronutrients
(p
<0.05),
Conclusions:
profiles
differed
for
EFG,
EPG,
emphasising
need
dietary
guidelines
tailored
subtypes.
Further
interventional
studies
are
needed
to
explore
these
findings,
particularly
associations
between
EFG
low
behaviours.
Language: Английский
Exploring the soluble (pro)renin receptor (sPRR) as a biomarker in pathophysiological disorders: Integrating machine learning and meta-analysis for insights into gestational diabetes
Expert Systems with Applications,
Journal Year:
2025,
Volume and Issue:
unknown, P. 126998 - 126998
Published: Feb. 1, 2025
Language: Английский
Multi-omics approaches for biomarker discovery and precision diagnosis of prediabetes
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 14, 2025
Recent
advancements
in
multi-omics
technologies
have
provided
unprecedented
opportunities
to
identify
biomarkers
associated
with
prediabetes,
offering
novel
insights
into
its
diagnosis
and
management.
This
review
synthesizes
the
latest
findings
on
prediabetes
from
multiple
omics
domains,
including
genomics,
epigenomics,
transcriptomics,
proteomics,
metabolomics,
microbiomics,
radiomics.
We
explore
how
these
elucidate
molecular
cellular
mechanisms
underlying
analyze
potential
predictive
value
disease
progression.
Integrating
data
helps
address
limitations
of
traditional
diagnostic
methods,
enabling
early
detection,
personalized
interventions,
improved
patient
outcomes.
However,
challenges
such
as
integration,
standardization,
clinical
validation
translation
remain
be
resolved.
Future
research
leveraging
artificial
intelligence
machine
learning
is
expected
further
enhance
power
technologies,
contributing
precision
tailored
management
prediabetes.
Language: Английский
Comparison of the Glycemic Impact of Popular Snack Bars in the Chilean Market
Journal of Pharmaceutical and Medicinal Research,
Journal Year:
2025,
Volume and Issue:
9(1), P. 149 - 152
Published: March 30, 2025
The
increased
consumption
of
snacks
has
raised
concerns
regarding
metabolic
health,
particularly
due
to
their
content
rapidly
absorbed
carbohydrates.
This
study
assessed
the
glycemic
impact
three
representative
snack
bars
from
Chilean
market:
a
plant-based
protein
bar
formulated
with
isomaltulose
(NotProtein®
Snack
Bar,
NPSB),
cereal-based
(CBS),
and
an
animal-based
(ABPS).
response
was
analyzed
in
ten
healthy
adults,
following
standardized
portions
containing
25
g
available
carbohydrates
crossover
trial.
results
indicated
that
NPSB
exhibited
lowest
load
(GL
=
2.2)
slowest
glucose
absorption,
more
sustained
compared
other
bars.
These
effects
are
attributed
its
formulation
isomaltulose,
as
well
higher
fiber
content,
low-molecular-weight
soluble
(LMW-SF).
CBS,
contrast,
had
highest
10.1),
reflecting
high
digestible
Reformulating
lower
profiles
functional
ingredients,
such
fibers
slow-digesting
carbohydrates,
could
contribute
improving
health
consumers
seeking
healthier
options.
Language: Английский
New insight on dietary strategies to increase insulin sensitivity and reduce diabetes prevalence: an expert perspective and recommendation
Discover Food,
Journal Year:
2025,
Volume and Issue:
5(1)
Published: May 16, 2025
Language: Английский
Effects of dietary approaches and exercise interventions on gestational diabetes mellitus: A systematic review and Bayesian network meta-analysis
Liang Zhang,
No information about this author
Fang Wang,
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Syoichi Tashiro
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et al.
Advances in Nutrition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100330 - 100330
Published: Oct. 1, 2024
Language: Английский
Glucose uptake in trophoblasts of GDM mice is regulated by the AMPK-CLUT3 signaling pathway
Zhenghua Xiao,
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Xue Liu,
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Xiaojin Luan
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et al.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 27, 2024
Abstract
GDM,
as
a
metabolic
disease
during
pregnancy,
regulates
GLUT3
translocation
by
AMPK,
thereby
affecting
glucose
uptake
in
trophoblasts.
It
provides
new
research
idea
and
therapeutic
target
for
alleviating
intrauterine
hyperglycemia
GDM.
STZ
was
used
to
construct
GDM
mice,
inject
AICAR
into
pregnant
observe
fetal
placental
weight;
flow
cytometry
employed
the
detection
of
primary
trophoblast
cells;
immunofluorescence
applied
detect
localization
AMPK
tissue;
Cocofal
microscope
cells;qRT-PCR
Western
blot
experiments
were
carried
out
expression
levels
CO-IP
utilized
interaction
AMPK.
Compared
with
normal
pregnancy
group,
weight
fetus
placenta
mice
increased
(P
<
0.001),
ability
trophoblasts
take
up
decreased
0.001).
In
addition,
activity
membrane
down-regulated
compared
0.05).
There
is
an
between
Activating
can
up-regulate
protein
0.05)
increase
We
speculate
that
inhibition
results
aberrant
GLUT3,
which
turn
attenuates
cells.
activates
improve
capacity
Language: Английский
Glycemic index and COVID-19 management: A comprehensive review of low, medium and high glycemic inde x foods
P. Saidaiah,
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Zeenath Banu,
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Geetha Arumugam
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et al.
Annals of Phytomedicine An International Journal,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: July 1, 2024
The
influence
of
low,
medium,
and
high
glycemic
index
(GI)
plants
on
the
management
COVID-19,
with
a
particular
focus
their
effects
blood
sugar
levels,
inflammation,
immune
function
is
examined
in
present
review.COVID-19
patients,
especially
those
underlying
conditions
like
diabetes,
hypertension,
cardiovascular
diseases,
often
face
more
severe
outcomes.The
GI
foods
plays
vital
role
managing
these
by
affecting
postprandial
levels
insulin
sensitivity.Low
are
emphasized
for
ability
to
stabilize
reduce
inflammatory
responses,
which
essential
COVID-19
symptoms
preventing
complications.Conversely,
medium
plants,
despite
nutritional
benefits,
can
cause
rapid
increases
enhance
processes,
necessitating
careful
dietary
planning.The
review
consolidates
current
research
how
various
impact
function,
highlighting
importance
diets
tha
t
support
anti-inflammatory
responses.It
offers
pra
ctical
recommendations
optimize
health
outcomes
advocating
greater
consumption
low-GI
such
as
vegetables,
legumes,
whole
grains,
while
recommending
moderation
intake
high-GI
refined
sugars
certain
processed
items.By
exploring
relationship
between
diet,
regulation,
response,
this
underscores
personalized
strategies
improving
recovery
longterm
patients.
Language: Английский