Evaluation of polysaccharides from Laetiporus sulphureus on the growth of gastrointestinal probiotics and in vitro digestion DOI Creative Commons

Xinting Zhu,

Shan Lin, Qi Wei

et al.

Frontiers in Sustainable Food Systems, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 18, 2024

Introduction Probiotics can improve immune responses and regulate the ecosystem of microorganisms in gastrointestinal tract. Methods Three primary models, including Reparameterized Gompertz, Huang, Baranyi Roberts models were evaluated developed to investigate effects Laetiporus sulphureus polysaccharides (LSP) on growth Lactobacillus plantarum, Streptococcus thermophilus, Clostridium tyrobutyricum , Bifidobacterium adolescentis . Results The Huang model Gompertz suitable for describing C. tyrobutyricum, S. B. L. plantarum LSP could increase population fluid environment stomach vitro. Discussion These results may support further development as a functional food or additive that has ability preserve digestive tract health.

Language: Английский

Spexin (Neuropeptide Q): Distribution, Functional Roles, and Emerging Therapeutic Perspectives DOI

Ritesh S. Tarwani,

Kamini R. Shirasath,

Sanjay N. Awathale

et al.

International Journal of Peptide Research and Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Jan. 8, 2025

Language: Английский

Citations

0
The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF DOI Creative Commons
Shenghua Zhou, Xuan Zhou, Panpan Zhang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 13, 2025

Heart failure with preserved left ventricular ejection fraction (HFpEF) is a disease that affects multiple organs throughout the body, accounting for over 50% of heart cases. HFpEF has significant impact on individuals’ life expectancy and quality life, but exact pathogenesis remains unclear. Emerging evidence implicates low-grade systemic inflammation as crucial role in onset progression HFpEF. Gut microbiota dysregulation associated metabolites alteration, including short-chain fatty acids, trimethylamine N-oxides, amino bile acids can exacerbate chronic inflammatory responses potentially contribute to In light these findings, we propose hypothesis “gut microbiota-inflammation-HFpEF axis”, positing interplay within this axis could be factor development This review focuses gut dysregulation-induced HFpEF’s etiology. It explores potential mechanisms linking cardiac dysfunction evaluates therapeutic restoring balance mitigating severity. The objective offer novel insights strategies management

Language: Английский

Citations

0
Potential Probiotics for the Therapy of Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons

Xiayun Li,

Liyan Yu,

Zong‐Gen Peng

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD), a prevalent metabolic disorder globally, has presented an urgent need for effective therapeutic agents. The complex pathogenesis of MASLD and the failure numerous clinical trials targeting this have prompted exploration probiotic intervention as novel strategy. Emerging evidence underscores pivotal role gut-liver axis in progression, particularly through dysregulation gut microbiota composition, impaired intestinal barrier integrity, aberrant bacterial metabolite signaling. Preclinical studies indicate that specific strains may ameliorate by restoring microbial homeostasis, fortifying function, attenuating hepatic inflammation via crosstalk. Preliminary further support beneficial effects probiotics reducing steatosis improving parameters. Future research should prioritize elucidating strain-specific mechanisms, optimizing formulations, addressing challenges related to long-term efficacy, safety, personalized regimens. This review comprehensively evaluates current on applications treatment highlights critical directions advancing translational field.

Language: Английский

Citations

0
Hesperidin improves cardiac fibrosis induced by β-adrenergic activation through modulation of gut microbiota DOI
Xia Liu, Weiwei Ju,

Erjiao Qiang

et al.

Journal of Pharmacology and Experimental Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 103578 - 103578

Published: April 1, 2025

Language: Английский

Citations

0
Microbiota-Based Intervention Alleviates High-Fat Diet Consequences Through Host-Microbe Environment Remodeling DOI Open Access

Lanlan Yi,

Zhipeng Li,

Hong Xu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1402 - 1402

Published: April 22, 2025

A high-fat diet leads to metabolic disturbances, which are important factors in the development of obesity. Gut microbial composition and diversity altered by a diet. In general, resulted increased Firmicutes abundance decreased alpha diversity. Bile acids (BAs) involved digestion absorption fats small intestine also substrates microorganisms with bile salt hydrolase (BSH) activity. High-fat diets (HFDs) have been shown alter gut microbiota BA profiles murine models. Similarly, probiotic supplementation reverses HFD-induced adverse effects. This review focuses on energy characteristics its effects body weight, plasma lipid-related biochemical markers, changes microbiome characteristics, role BAs. The regular mechanism affects intestinal microenvironment was attempted be found.

Language: Английский

Citations

0
Research Progress of Intestinal Flora in Colorectal Cancer DOI Open Access

Wenli Wei,

Qing Zhang

Journal of Biosciences and Medicines, Journal Year: 2024, Volume and Issue: 12(03), P. 122 - 129

Published: Jan. 1, 2024

Colorectal cancer, as a common malignant tumor, has been increasing in incidence year by and become one of the leading causes death worldwide. Meanwhile, researchers have found close relationship between dysbiosis gut microbiota colorectal which further triggered indepth exploration role pathogenesis, diagnosis, treatment cancer. Studies shown that there are specific microbial changes cancer tissues, including enrichment or depletion certain bacterial species, may be associated with tumor growth, invasion, metastasis. Additionally, to closely linked microenvironment, immune response, chemotherapy drug metabolism, other factors. In this context, it is imperative study A comprehensive understanding interaction not only helpful revealing novel mechanisms development, but also holds promise providing new strategies targets for early individualized treatment, prevention This review aims thoroughly discuss research progress its compositional characteristics, occurrence development potential clinical applications. The goal provide references insights field.

Language: Английский

Citations

0
Dietary Polycan, a β‐glucan originating from Aureobasidium pullulansSM‐2001, attenuates high‐fat‐diet‐induced intestinal barrier damage in obese mice by modulating gut microbiota dysbiosis DOI Creative Commons
Gwangpyo Ko, Tatsuya Unno, Young‐Suk Kim

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(8), P. 5824 - 5835

Published: May 26, 2024

Abstract Various metabolic diseases caused by a high‐fat diet (HFD) are closely related to gut microbiota dysbiosis and epithelial barrier dysfunction. Polycan, type of β‐glucan, is effective in treating anti‐obesity HFD. However, the effect Polycan on damage still unknown. In this study, effects intestinal were investigated using HFD‐induced obese model mice. C57BL/6 mice fed HFD for 12 weeks treated with two different doses (250 500 mg/kg) orally administered during 9 12. supplementation increased expression tight junction genes (zonula occludens‐1, occludin, claudin‐3) short‐chain fatty acid (SCFA) content while reducing toxic substances (phenol, p ‐cresol, skatole). Most significantly, enriched SCFA‐producing bacteria (i.e., Phocaeicola , Bacteroides Faecalibaculum Oscillibacter Lachnospiraceae, Muribaculaceae), decreased Firmicutes/Bacteroidetes ratio substances‐producing Olsenella Clostridium XVIII, Schaedlerella ). Furthermore, microbial functional capacity prediction revealed that many SCFA‐related KEGG enzymes substance‐related depleted. These findings indicated has potential alleviate modulating function composition microbiota.

Language: Английский

Citations

0
Evaluation of polysaccharides from Laetiporus sulphureus on the growth of gastrointestinal probiotics and in vitro digestion DOI Creative Commons

Xinting Zhu,

Shan Lin, Qi Wei

et al.

Frontiers in Sustainable Food Systems, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 18, 2024

Introduction Probiotics can improve immune responses and regulate the ecosystem of microorganisms in gastrointestinal tract. Methods Three primary models, including Reparameterized Gompertz, Huang, Baranyi Roberts models were evaluated developed to investigate effects Laetiporus sulphureus polysaccharides (LSP) on growth Lactobacillus plantarum, Streptococcus thermophilus, Clostridium tyrobutyricum , Bifidobacterium adolescentis . Results The Huang model Gompertz suitable for describing C. tyrobutyricum, S. B. L. plantarum LSP could increase population fluid environment stomach vitro. Discussion These results may support further development as a functional food or additive that has ability preserve digestive tract health.

Language: Английский

Citations

0