Testosterone treatment impacts the intestinal microbiome of transgender individuals

mSphere, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

ABSTRACT Medical modulation of sex hormone levels is a cornerstone treatment for many conditions that impact well-being, including cancer, fertility/infertility, gender dysphoria, and chronic metabolic diseases such as diabetes obesity. The microbial residents the intestine, known microbiota, interact with hormones in there correlative evidence this interaction bidirectional. Based on these published findings, we hypothesized transgender individuals receiving exogenous testosterone part their gender-affirming medical might undergo changes intestinal microbiome. To test this, collected 26 stool samples from nine before up to 8 months after initiation subjected metagenomic analysis. While no species were significantly associated duration therapy, pathways generate glutamate increased abundance, while those consume decreased. Glutamate precursor arginine, increase arginine its metabolites plasma. We hypothesize increases uptake by enterocytes, thus decreasing access microbiota amino acid. pilot study establishes therapy microbiome, more comprehensive necessary establish testosterone-driven shifts metatranscriptome, metabolome, plasma metabolome. IMPORTANCE human intestine inhabited large community microbes Members microbiome diet along host. Thus, metabolomes host microbe are intricately linked. Testosterone alters In particular, positively correlated. investigate analyzed metagenomes treatment. project, found modest structure but an abundance spare consumption. propose uses amount available

Language: Английский

Gender and activity disparities in the relationship between circadian syndrome and gallstone disease

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 23, 2024

Objective To explore the potential correlation between gallstone disease (GSD) prevalence and circadian syndrome (CircS). Methods The cross-sectional research utilized data spanning 2017 to March 2020, sourced from National Health Nutrition Examination Survey (NHANES). GSD were collected via questionnaires, with appropriate sample weights applied ensure study population was representative. Three multivariable logistic regression models built clarify connection CircS GSD. Furthermore, subgroup analysis interaction test carried out, categorized based on demographic traits lifestyle aspects, discern influence of these variables correlation. Results included 4,126 participants, a 38.68% for 12.04% indicated positive (Odds Ratio (OR) = 1.336, 95% Confidence Interval (CI): 1.048, 1.702). When stratified by number components, observed components (P trend < 0.05). In particular, individuals six or more had higher than those three fewer (OR 2.608, CI: 1.464, 4.647). revealed that mainly in female 1.701, 1.236, 2.341) not engaged moderate activity 1.990, 1.158, 3.418). Conclusion There is prevalence, particularly among females engaging activity. These findings offer new insights directions may impact preventive therapeutic strategies.

Language: Английский