GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis DOI Creative Commons
Germana Cocozza,

Ludovica Maria Busdraghi,

Giuseppina Chece

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 124, P. 280 - 293

Published: Dec. 11, 2024

Weight loss is a common early sign in amyotrophic lateral sclerosis (ALS) patients and negatively correlates with survival. In different cancers metabolic disorders, high levels of serum growth differentiation factor 15 (GDF15) contribute to decrease food intake body weight, acting through GDNF family receptor alpha-like (GFRAL). Here we report that GDF15 highly expressed the peripheral blood ALS hSOD1

Language: Английский

Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues DOI Creative Commons

Kennedy R. Wiens,

Naved Wasti,

Omar Orlando Ulloa

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5525 - 5525

Published: Nov. 22, 2024

Microglia, the brain immune cells, support neurons by producing several established neurotrophic molecules including glial cell line-derived factor (GDNF) and brain-derived (BDNF). Modern analytical techniques have identified numerous phenotypic states of microglia, each associated with secretion a diverse set substances, which likely include not only canonical factors but also other less-studied that can interact provide trophic support. In this review, we consider following eight such candidate cytokines: oncostatin M (OSM), leukemia inhibitory (LIF), activin A, colony-stimulating (CSF)-1, interleukin (IL)-34, growth/differentiation (GDF)-15, fibroblast growth (FGF)-2, insulin-like (IGF)-2. The available literature provides sufficient evidence demonstrating murine cells produce these cytokines they exhibit activity in at least one neuronal model. Several distinct types are partially overlap among considered, reflecting either their intrinsic properties or lack comprehensive studies covering full spectrum effects. scarcity human-specific is another significant knowledge gap revealed review. Further on potential microglia-derived warranted since may be used as targeted treatments for neurological disorders.

Language: Английский

Citations

1

Advances in glial cell line-derived neurotrophic factor DOI
Jin Yang

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Oct. 10, 2024

Glial cell line-derived neurotrophic factor (GDNF) is a potent with significant research value due to its profound effects on dopaminergic, cholinergic, and motor neurons. Initially identified for neuroprotective role in dopaminergic neurons, GDNF has been found support various neuronal populations plays crucial neural development, maintenance, repair. This review provides comprehensive overview of the molecular characteristics, tissue distribution, physiological function protective effect series diseases, emphasizing potential therapeutic applications. Meanwhile, this study discusses challenges delivering across blood-brain barrier explores current strategies enhance clinical efficacy, including use gene therapy innovative delivery methods. In summary, underscores promise as agent neurodegenerative diseases nerve injuries, highlighting need further translate these findings into practice.

Language: Английский

Citations

0

GDF15 Associates with, but is not Responsible for, Exercise-Induced Increases in Corticosterone and Indices of Lipid Utilization in Mice DOI

Meagan Arbeau,

Bradley J. Baranowski,

Stewart Jeromson

et al.

Journal of Applied Physiology, Journal Year: 2024, Volume and Issue: 137(6), P. 1512 - 1523

Published: Oct. 31, 2024

Circulating growth differentiation factor 15 (GDF15) increases during exercise, but the physiological role that it plays has not been elucidated. Recent data suggest GDF15 regulates corticosterone and lipid utilization. Here we demonstrate postexercise nutrient availability influences in recovery from exercise is associated with indices of However, associations were causal as exercise-induced fatty acids, beta-hydroxybutyrate, intact −/− mice.

Language: Английский

Citations

0

GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem DOI Creative Commons
Cecilia Hes,

Luting Gui,

Alexandre Bay

et al.

Molecular Metabolism, Journal Year: 2024, Volume and Issue: unknown, P. 102070 - 102070

Published: Nov. 1, 2024

Language: Английский

Citations

0

GDF15/MIC-1: a stress-induced immunosuppressive factor which promotes the aging process DOI Creative Commons
Antero Salminen

Biogerontology, Journal Year: 2024, Volume and Issue: 26(1)

Published: Dec. 6, 2024

Abstract The GDF15 protein, a member of the TGF-β superfamily, is stress-induced multifunctional protein with many its functions associated regulation immune system. signaling provides defence against excessive inflammation induced by diverse stresses and tissue injuries. Given that aging process low-grade inflammatory state, called inflammaging, it not surprising expression gradually increases aging. In fact, core factor secreted senescent cells, state senescence-associated secretory phenotype (SASP). Many age-related stresses, e.g., mitochondrial endoplasmic reticulum as well inflammatory, metabolic, oxidative induce GDF15. Although an effective anti-inflammatory modulator, there robust evidence pro-aging promoting process. only modulator but also potent immunosuppressive enhancer in chronic states. can stimulate responses either non-specifically via receptors superfamily or specifically through GFRAL/HPA/glucocorticoid pathway. stimulates network activating MDSCs, Tregs, M2 macrophages triggering inhibitory checkpoint cells. Immunosuppressive suppress processes they evoke detrimental effects aged tissues, such cellular senescence, fibrosis, atrophy/sarcopenia. It seems survival go awry persistent thus diseases.

Language: Английский

Citations

0

GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis DOI Creative Commons
Germana Cocozza,

Ludovica Maria Busdraghi,

Giuseppina Chece

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 124, P. 280 - 293

Published: Dec. 11, 2024

Weight loss is a common early sign in amyotrophic lateral sclerosis (ALS) patients and negatively correlates with survival. In different cancers metabolic disorders, high levels of serum growth differentiation factor 15 (GDF15) contribute to decrease food intake body weight, acting through GDNF family receptor alpha-like (GFRAL). Here we report that GDF15 highly expressed the peripheral blood ALS hSOD1

Language: Английский

Citations

0