Associations Between Dietary Factors and Breast Cancer Risk: A Systematic Review of Evidence from the MENA Region

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 394 - 394

Published: Jan. 22, 2025

Background: The Middle East and North Africa (MENA) region is witnessing a continuous rise in the incidence of breast cancer (BC). This characterized by distinct cultural lifestyle habits. Despite importance diet as modifiable risk factor for BC, its role development BC within MENA context has not been extensively studied. systematic review aims to identify synthesize existing evidence regarding effect different dietary factors on among women from this region. Methods: We systematically reviewed scientific literature observational studies that examined association between specific MENA, accordance with Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) statement. Our comprehensive search included databases such PubMed, Web Science, ScienceDirect, Scopus, identified total 18,085 records, which 65 met our inclusion criteria were assessed quality using National Institute Health Quality Assessment Tool. Results: findings categorized into food groups, nutrients, patterns. Studies have consistently shown consumption fruit vegetables, fish seafood, black tea are associated reduced risk. In contrast, intake milk white bread linked an increased Specific patterns Mediterranean diet, healthy plant-based antioxidant index, overall negative Conversely, insulin index load, glycemic inflammatory unhealthy BC. For remaining factors, research was too limited or inconsistent draw conclusions. Conclusions: highlight significant modulating region, area faces notable gap topic. Further essential deepen understanding develop targeted recommendations prevention population.

Language: Английский

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Liquid saliva analysis using optofluidic photonic crystal fiber for detection of oral potentially malignant disorders

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: unknown, P. 125788 - 125788

Published: Jan. 1, 2025

Oral potentially malignant disorders (OPMD) serve as early indicators of oral cancer. These conditions require reliable, non-invasive and real-time diagnostic methods for effective detection screening. Saliva, an easily accessible biofluid, has emerged a promising tool to detect OPMD-associated biomarkers. This proof-of-concept study investigated the application suspended-core optofluidic photonic crystal fibers (PCF) Raman spectroscopy distinguish between saliva from healthy controls OPMD patients. novel approach provides enhanced signals through prolonged interactions excitation light sample along length PCF. spectra liquid samples were collected eleven participants, including six patients five controls. Notable spectral differences identified at 1123 cm-1, 1251 1454 which correspond carbohydrates, proteins, lipids, respectively. In vivo tissue measurements recorded reference comparative analysis same Our findings suggest that PCF-based holds promise platform cancer screening by enabling monitoring subtle molecular changes in saliva.

Language: Английский

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Smoking Avoidance, Physical Activity and Diet as Preventative Behaviours for Lung, Prostate and Colorectal Cancer - A Comparison of the Extended Parallel Process Model Groups

International Journal of Public Health, Journal Year: 2025, Volume and Issue: 70

Published: Feb. 4, 2025

Objectives An analysis of men’s perceptions the role three health behaviours (smoking avoidance, physical activity, and diet) in relation to subjective threat lung, prostate, colorectal cancers, with adoption Extended Parallel Process Model (EPPM). Methods The study was conducted using a survey questionnaire by Computer Assisted Web Interviewing on representative sample 1,000 male Polish citizens aged 18–65. Results Prostate cancer considered most likely severe type cancer. A healthy diet intervention that effective one be implemented for Respondents perceived smoking avoidance intervention, while considering this least feasible strategy implement lung In all behaviours, Indifferent group numerous. Belonging EPPM groups mainly associated educational level, financial situation, self-assessed status. Conclusion need interventions aimed at: increase risk context incidence, self-efficacy reduce level losses from undertaking avoidance.

Language: Английский

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Cancer prevalence and its determinants in Hungary: Analyzing data from the 2009, 2014, and 2019 European Health Interview Surveys

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0315689 - e0315689

Published: Feb. 13, 2025

Background and aim Hungary has the fifth highest cancer incidence rate in European Union, with an age-standardized (ASR) of 336.7 per 100,000 according to GLOBOCAN 2022. Additionally, holds mortality EU, ASR 148.1 100,000. This study aimed investigate sociodemographic, lifestyle, chronic disease-related factors affecting prevalence Hungarian population. Materials methods Data from 2009, 2014, 2019 installments Health Interview Survey conducted were pooled, resulting a representative sample 16,480 individuals. Weighted multiple logistic regression models used analyze data, goodness fit assessed using Hosmer-Lemeshow test. The best-fitting further evaluated ROC analysis calculate Area Under Curve (AUC) assess discriminative ability. Results Urban residency was associated higher odds 2014 (OR 1.85 [CI: 1.08–3.16]) pooled data 1.44 1.08–1.9]). Employed individuals had lower (2014: OR 0.34 0.16–0.74]; pooled: 0.64 0.45–0.92]). Among comorbid conditions, peptic ulcer (2009: 1.74 1.13–2.69]; 2019: 3.2 1.58–6.47]; 1.83 1.31–2.54]) liver disease 3.52 1.73–7.17]; 2.5 1.4–4.47]) significantly odds. Reporting bad health linked increased risk 2.92 1.87–4.58]; 2014: 5.52 3.23–9.45]; 2.23 1.26–3.95]). Conclusion Comorbid conditions such as increase Hungary. residents require targeted preventive measures, unemployment should be addressed. Early detection through appropriate screening effective management are essential prevent escalation reduce overall prevalence.

Language: Английский

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Emerging drivers of female bladder cancer: a pathway to precision prevention and treatment

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 14, 2025

Purpose Bladder cancer is a public health concern, with smoking and occupational exposure being major risk factors. However, specific risks in women, particularly hormonal, lifestyle, environmental factors, are underexplored. This study aimed to assess these factors focusing on smoking, exposure, recurrent urinary tract infections (UTIs), body mass index (BMI), menopausal status, family history of cancer. Materials methods retrospective cohort included 850 women diagnosed bladder (2018–2023) age-matched controls. Data UTIs, BMI, were collected from medical records: multivariate logistic regression propensity score matching identified independent Subgroup analysis explored interactions between status other Results Smoking (OR = 2.15, p 0.002), 1.89, 0.007), UTIs 1.72, 0.013) significant post-menopausal women. Menopausal amplified the effects but was not an predictor. BMI showed no associations. Conclusion Smoking, key for especially highlighting need targeted prevention strategies.

Language: Английский

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Understanding Psychological Distress and Body Image Disturbances among Breast Cancer Survivors: A Role of Surgery

Bulletin of Business and Economics (BBE), Journal Year: 2025, Volume and Issue: 14(1), P. 1 - 5

Published: Feb. 13, 2025

Breast cancer (BC) diagnosis and treatment can affect women both physically psychologically. Women with BC undergo various painful debilitating therapies as well emotional trauma. Additionally, modalities bring about multiple changes, causing distress alteration in one’s appearance. This study aimed to assess the psychological body image disturbances after modified radical mastectomy (MRM) among survivors. Correlational research design was used conduct this quantitative research. Survey administered closed ended questionnaires method of data collection. Purpose sampling technique employed select sample 50 (married=31, unmarried=19) breast Three were two instrument used; DASS-21 (Henry & Crawford, 2005) Body Image Scale ((Hopwood et al., 2001). Findings reveal that there is positive correlation between disturbance. Moreover, depression, anxiety stress are significant predictors survivors experience high rates anxiety, stress, dissatisfaction. Furthermore, unmarried report higher score disturbance compared married. Depression, issues common Follow-up management plans for should also include evaluation addressing patients undergoing mastectomy.

Language: Английский

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Cancer prevention: past challenges and future directions

Genes and Environment, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 27, 2025

Abstract Almost 70 years have passed since the molecular mechanism of carcinogenesis was hypothesized to involve multiple gene mutations. More than 1,000 cancer-related genes, including oncogenes and tumor suppressor accelerate by altering functions expression through mutations epigenetic changes been shown cause multistep in several organ cancers. The elucidation abnormalities has led development molecular-targeted therapies that focus on driver molecules, known as precision medicine, addition conventional treatments such surgery, radiotherapy, chemotherapy. Now cancer largely elucidated, options for treatment its outcomes improved, research is moving next stage: prevention. Cancer prevention using chemicals first proposed approximately 50 ago. It concept stabilizing, arresting, or reverting precancerous lesions normal tissues synthetic vitamin A analogs (retinoids). chemoprevention now considered consist three elements: “primary prevention,” which prevents tumors benign converting into more malignant ones; “secondary aims early detection screening treatment; “tertiary reduces risk recurrence extends time until death from treatment. Consequently, there no clear boundary between strategies. Therefore, targets entire process, cells lesions, progression tumors, cancer. Basic clinical revealed influenced race, regional, national differences, well individual differences genetic factors, environmental lifestyle habits. This review provides an overview progress made summarizes future directions.

Language: Английский

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Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 843 - 843

Published: Feb. 28, 2025

Prostate cancer (PCa) accounts for roughly 15% of diagnosed cancers among men, with disease incidence increasing worldwide. Age, family history and ethnicity, diet, physical activity, chemoprevention all play a role in reducing PCa risk. The prostate is an exocrine gland that characterized by its multi-functionality, being involved reproductive aspects such as male ejaculation orgasmic ecstasy, well playing key roles the regulation local systemic concentrations 5α-dihydrotestosterone. increase androgen receptors at ventral first elevated response induced copulation. growth function mediated androgen-dependent mechanism. Binding 5-DHT to (AR) results formation 5α-DHT:AR complex. interaction complex specific DNA enhancer element androgen-regulated genes leads androgen-specific target maintain homeostasis. Consequently, may significant reduction Thus, frequent absence risky sexual behavior possible approach prevention PCa. In this review, we provide insight into mechanisms regulating impact on

Language: Английский

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Design, Development, and Evaluation of Silver Nanoparticles Synthesized via Green Technology for Antioxidant, Antimicrobial, and Anticancer Activities

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 3, 2025

Language: Английский

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Depression as a Risk Factor for Gynecological Cancers: Evidence from NHANES Data

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 615 - 625

Published: March 1, 2025

Depression is one of the leading sources disease burden globally and plays a significant role in occurrence development many cancers, representing an important health risk. However, relationship between depression risk gynecologic cancers has not been fully assessed. This study aims to explore association cancers. We selected 11,574 participants from NHANES 2009-2018 cycles, among which 274 had cancer (GC), 137 cervical (CC), 48 ovarian (OC), 89 endometrial (EC). Box plots were used assess differences PHQ-9 scores non-cancer groups. Logistic regression models restricted cubic spline (RCS) employed evaluate Subgroup analyses interaction tests examined consistency across different characteristics. There was difference group group. In multivariable logistic analysis, positively correlated with GC, OC, EC, while no found CC Additionally, RCS model also indicated nonlinear subgroup suggested that OC consistent groups, whereas GC EC showed heterogeneity relation race marital status. Specifically, higher levels are associated increased Future attention should be given impact on incidence particularly EC.

Language: Английский

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