Preventive Intake of a Multiple Micronutrient Supplement during Mild, Acute SARS-CoV-2 Infection to Reduce the Post-Acute COVID-19 Condition: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial DOI Open Access
Teresa Maria Tomasa-Irriguible, Ramon Monfà,

Cristina Miranda-Jiménez

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1631 - 1631

Published: May 26, 2024

Patients hospitalized with COVID-19 have low levels of vitamins and trace elements. This could lead to a post-acute condition (PCC) that can worsen patient’s quality life. We aimed study the baseline micronutrient status patients assess whether multiple supplement (MMS) taken for 2 weeks at first sign symptoms would be able reduce incidence PCC. double-blind, placebo-controlled, randomized clinical trial was conducted in adult outpatients acute COVID-19, recruited between 2021 2023 Spain. Of 285 assessed eligibility, 267 were 246 included intent-to-treat population. The mean age 46.8 years, 68% female. Overall, 54.6% had deficiencies phase baseline, 26.2% PCC after 180 days follow-up (D180). most frequently recorded neurological (14.1%), 24% scoring worse cognitive tests compared their status. rate D180 similar placebo (25.0%) intervention (27.7%) groups, without significant differences (p = 0.785). Age over 50 years relevant risk factor developing PCC, followed by female sex. important protective against SARS-CoV-2 vaccination. In this population predominantly middle-aged, white women not requiring hospital admission, MMS intake 14 symptom onset did prevent nor improve D180.

Language: Английский

Preventive Intake of a Multiple Micronutrient Supplement during Mild, Acute SARS-CoV-2 Infection to Reduce the Post-Acute COVID-19 Condition: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial DOI Open Access
Teresa Maria Tomasa-Irriguible, Ramon Monfà,

Cristina Miranda-Jiménez

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1631 - 1631

Published: May 26, 2024

Patients hospitalized with COVID-19 have low levels of vitamins and trace elements. This could lead to a post-acute condition (PCC) that can worsen patient’s quality life. We aimed study the baseline micronutrient status patients assess whether multiple supplement (MMS) taken for 2 weeks at first sign symptoms would be able reduce incidence PCC. double-blind, placebo-controlled, randomized clinical trial was conducted in adult outpatients acute COVID-19, recruited between 2021 2023 Spain. Of 285 assessed eligibility, 267 were 246 included intent-to-treat population. The mean age 46.8 years, 68% female. Overall, 54.6% had deficiencies phase baseline, 26.2% PCC after 180 days follow-up (D180). most frequently recorded neurological (14.1%), 24% scoring worse cognitive tests compared their status. rate D180 similar placebo (25.0%) intervention (27.7%) groups, without significant differences (p = 0.785). Age over 50 years relevant risk factor developing PCC, followed by female sex. important protective against SARS-CoV-2 vaccination. In this population predominantly middle-aged, white women not requiring hospital admission, MMS intake 14 symptom onset did prevent nor improve D180.

Language: Английский

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