Probiotic Functions in Fermented Foods: Anti-Viral, Immunomodulatory, and Anti-Cancer Benefits

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2386 - 2386

Published: July 28, 2024

Fermented foods can provide many benefits to our health. These are created by the action of microorganisms and help support digestive health immune system. include yogurt,

Language: Английский

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The effects of vitamin D supplementation on serum lipid profiles in people with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 5, 2024

Introduction People with type 2 diabetes (T2D) are highly susceptible to the development of cardiovascular diseases. Previous studies have suggested that application vitamin D may offer potential benefits in improving lipid profiles, but these effects remain controversial. Methods This systematic review and meta-analysis focused on supplementation serum profiles people T2D. Randomized controlled trials (RCTs) assessing published before September 19th, 2023, were identified PubMed, Embase, Cochrane Library. protocol was registered PROSPERO (CRD42023461136). The random-effects model employed estimate unstandardized mean differences (MD) 95% confidence intervals (CIs). quality assessed by Risk Bias tool 2. Results Overall, 20 RCTs involving 1711 participants included. indicated significantly improves high-density lipoprotein (HDL) (MD: 1.63 mg/dL, CI: 0.19 3.08, P = 0.03), triglyceride (TG) levels -8.56 -15.23 -1.89, 0.01). However, failed improve low-density (LDL) total cholesterol (TC) levels. Subgroup analyses meta-regressions higher doses shorter duration intervention more likely favorable profiles. Moreover, lower baseline BMI 25-hydroxy exhibited greater improvements following supplementation. Conclusions highlighted HDL TG while not exhibiting significant LDL TC Further long-term high-quality still needed draw precise conclusions. Systematic registration https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=461136 .

Language: Английский

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The efficacy of cholecalciferol in the comprehensive treatment of patients with autoimmune diabetes

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 20(8), P. 565 - 572

Published: Jan. 4, 2025

Background. Vitamin D deficiency is a global issue negatively affecting the course of autoimmune diabetes, including classical type 1 diabetes mellitus (T1DM) and latent in adults (LADA). plays vital role immune response regulation, maintaining β-cell function pancreas, metabolic balance. The purpose study was to evaluate efficacy adding cholecalciferol at dose 20,000 IU (once weekly for 3 months) standard therapy improve status patients with T1DM LADA. Materials methods. A total 72 participated study: 36 They were divided into subgroups depending on treatment received: basic or vitamin supplementation. comprehensive evaluation carbohydrate metabolism indicators (fasting glycemia, HbA1c, HOMA-IR, insulin, C-peptide levels), activity (antibodies glutamic acid decarboxylase (antiGAD)), lipid profile conducted before after treatment. Results. addition significantly increased serum 25(OH)D levels, ensuring substantial improvement patients. In groups receiving supplemental cholecalciferol, there notable reduction fasting glucose HbА1с, antiGAD titers, indicating positive impact glycemic control decrease activity. Additionally, exhibited improvements metabolism, decreased levels cholesterol, low-density lipoprotein triglycerides, high-density cholesterol. Particularly significant an increase observed LADA, reflecting enhanced pancreas. This effect may be related as well anti-inflammatory properties D, which contribute maintenance β-cells their ability secrete insulin. confirms pleiotropic effects D: reducing inflammation, impro­ving insulin sensitivity, normalizing profiles, supporting function. Conclusions. findings highlight importance monitoring correcting particularly presence deficiency. above data could used optimize therapeutic approaches reduce risk complications this patient population.

Language: Английский

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Vitamin D Deficiency and Cardiovascular Disease Risk Factors Among American Indian Adolescents: The Strong Heart Family Study

Preventing Chronic Disease, Journal Year: 2025, Volume and Issue: 22

Published: April 3, 2025

We aimed to describe the prevalence of vitamin D deficiency among American Indian adolescents and determine its association with cardiovascular disease (CVD) risk factors. Our study population consisted 307 (aged ≤20 years) participating in Strong Heart Family Study serum 25-hydroxyvitamin (25[OH]D) measured on samples collected during baseline examinations (2001-2003). defined as 25(OH)D ng/mL. evaluated outcomes related obesity (BMI, waist circumference, wait-to-hip ratio, body fat percentage), diabetes, cholesterol, metabolic syndrome. used generalized estimating equations whether differed according status, while controlling for covariates. To incidence, we conducted a follow-up examination median 5.8 years after (2006-2009) second 13.3 (2014-2018). calculated incidence rates (IR) per 100 person-years total group stratified by status at baseline. Finally shared frailty cox proportional hazards models if The was 50.8% baseline, it associated obesity, low HDL-C, syndrome, By first follow-up, IRs were following: (5.03), diabetes (1.07), any dyslipidemia (10.80), syndrome (3.31). IR significantly higher those (vs without) (1.32 vs 0.68 person-years; P = .02), although not significant adjusting Vitamin adolescence may be CVD factors also contribute development later life.

Language: Английский

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Association of serum 25-hydroxy vitamin D status with cardiometabolic risk factors and total and regional obesity in southern Iran: evidence from the PoCOsteo study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 3, 2024

Cardiometabolic risk factors increase the chance of developing cardiovascular disease (CVD) and type 2 diabetes. Most CVD are influenced by total regional obesity. A higher may be linked to vitamin D deficiency, which is more prevalent in older population. With goal evaluating association between cardiometabolic obesity adults, this research included 25 (OH) D3 concentrations biochemical markers associated with diseases, as well adiposity, was measured DXA. 1991 participants PoCOsteo study were included. Overall, 38.5% had deficiency. After adjusting for confounders, results multiple linear logistic regression suggested an inverse body mass index (P = 0.04), waist circumference 0.001), fat 0.02), android visceral < subcutaneous 0.01), trunk 0.006), arm 0.03), high systolic blood pressure 0.004), cholesterol LDL-cholesterol serum triglycerides fasting glucose 0.001). Additionally, decreased dyslipidemia 2%. Our showed a significant number factors, including

Language: Английский

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The impact of vitamin D status on lipid profiles and atherogenic dyslipidemia markers in children and adolescents with obesity

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(11), P. 2596 - 2605

Published: July 22, 2024

Language: Английский

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Vitamin D deficiency in patients with retinal vein occlusion: a systematic review and meta-analysis

International Journal of Retina and Vitreous, Journal Year: 2024, Volume and Issue: 10(1)

Published: July 27, 2024

Abstract Background This review aims to substantiate the correlation between vitamin D and retinal vein occlusion (RVO) within medical literature. Method A systematic meta-analysis were conducted in PubMed, SCOPUS, Web of Science, Embase until December 10th, 2023. meticulous literature search was undertaken identify analyze all observational-analytical papers reporting levels RVO patients. The principal outcome measures centered on comparative assessment patients with (cases) those devoid (controls). protocol registered PROSPERO (code: CRD42024499853). Results total six relevant studies consisting 589 participants included this meta-analysis. results indicated a significant association deficiency increased risk (Odds ratio = 14.51; 95% CI: [1.71, 122.59], P 0.014); exhibited decrease serum by 1.91ng/mL (95% [-2.29, -1.54], < 0.001). Moreover, there no difference observed central (CRVO) branch (BRVO) subtypes ( 0.63). Conclusion have more than healthy controls. These contribute growing body evidence highlighting intricate role supplementation as both prophylactic treatment strategy RVO. registration identifier : CRD42024499853.

Language: Английский

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Dyslipidemia in Peritoneal Dialysis: Implications for Peritoneal Membrane Function and Patient Outcomes

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2377 - 2377

Published: Oct. 17, 2024

Dyslipidemia is a common metabolic complication in patients undergoing peritoneal dialysis (PD) and has traditionally been viewed primarily terms of cardiovascular risk. Current guidelines do not recommend initiating lipid-lowering therapy due to insufficient evidence its benefits on mortality. However, the impact dyslipidemia PD may extend beyond concerns, influencing PD-related outcomes such as ultrafiltration rate, residual kidney function, technique survival, overall This review challenges traditional perspective by discussing dyslipidemia’s potential role complications, which account for observed link between increased all-cause mortality patients. It explores pathophysiology PD, molecular mechanisms linking membrane dysfunction, summarizes clinical supporting this hypothesis. In addition, paper examines therapeutic strategies manage improve function patient outcomes. The calls future research investigate contributor dysfunction develop targeted interventions

Language: Английский

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The Impact of Atorvastatin Treatment on the Distribution of Low-Density Lipoprotein Subfractions and the Level of Vitamin D in Patients After Acute Myocardial Infarction: Preliminary Findings

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11264 - 11264

Published: Oct. 19, 2024

Clinical trial results indicate that statin therapy aimed at normalising the lipid profile can prevent and reduce risk of cardiovascular events. Both LDL HDL consist several subfractions, with only smallest densest subfractions being most atherogenic. We examine effect Atorvastatin treatment not on basic parameters but also atherogenic lipoprotein 25(OH)D levels in patients after first acute myocardial infarction. The study population had previously received lipid-lowering medications. Serum concentration was determined by direct competitive immunochemiluminescent assays. Lipoprotein including VLDL, IDL-C, IDL-B, IDL-A, as well LDL1, LDL2 (large LDL), LDL3-7 (sdLDL), were measured serum (Lipoprint® system). Almost all deficiency. primarily reduced strongly sdLDL decreased less large subfractions. A statistically significant reduction VLDL cholesterol IDL fractions observed. Analysing provides a more detailed insight into metabolism enables identification phenotype. may thus become accurate prognostic biomarkers targets for therapy. Vitamin D deficiency is associated dyslipidaemia, particularly high sdLDL.

Language: Английский

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The Relationship between Vitamin D and TyG Index in Prediabetes and Type 2 Diabetes Mellitus among an Indian Tribal Community: A Cross-Sectional Study

BioMed, Journal Year: 2024, Volume and Issue: 4(4), P. 404 - 418

Published: Oct. 8, 2024

Background: Vitamin D deficiency is thought to increase the likelihood of insulin resistance (IR) and diabetes onset. The objective this study was examine association between triglyceride glucose (TyG) index vitamin levels in individuals with prediabetes type 2 mellitus (T2DM) tribal community India. Methods: This included 270 participants, consisting 90 prediabetes, T2DM, control patients. Anthropometric biochemical characteristics were evaluated all participants. 25-hydroxyvitamin [25(OH)D] measured using a chemiluminescent immunoassay. TyG computed as Ln [fasting triglycerides (mg/dL) × fasting (mg/dL)]/2. Spearman correlation analysis linear regression performed assess relationship 25(OH)D people diagnosed T2DM. optimum cut-off value for detecting determined by receiver operating characteristic (ROC) curve analysis. Results: We observed significant reduction T2DM compared those group. However, significantly greater than controls. Statistical revealed negative both Conclusions: demonstrated identified an independent predictor

Language: Английский

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