Eriodictyol 5-O-methyl ether inhibits prostate cancer progression through targeting STAT3 signaling and inducing apoptosis and paraptosis

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 766, P. 110331 - 110331

Published: Feb. 7, 2025

Language: Английский

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Sophocarpine inhibits the proliferation and induces apoptosis of glioblastoma cells through regulating the miR-21/PTEN/PI3K/AKT axis

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 8, 2025

Sophocarpine (SC) has been reported to suppress tumorigenesis. But the effect of SC on glioblastoma (GBM) is unknown. This study explored anti-proliferation and pro-apoptosis effects GBM cells molecular mechanism. Different concentrations were used treat human astrocyte NHA lines LN229 SF539. CCK-8 was applied analyze cell toxicity proliferation. qRT-PCR western blot measure RNA protein expressions, respectively. Cell cycle apoptosis determined by flow cytometry assay. The results indicated that inhibited proliferation induced SF539 in a dose-dependent manner. arrest G0/G1 phase increased after treatment. Moreover, downregulated miR-21 expression upregulated PTEN cells. Overexpression partly abrogated cells, while exogenous partially eliminated pro-proliferation anti-apoptosis Furthermore, treatment decreased levels PI3K/AKT pathway-related p-PI3K, p-AKT PIP3 pathway activator 740Y-P reversed reduced enhanced SC-treated Significantly, we verified suppressed via inhibiting it not entirely dependent upregulation PTEN. Consequently, potential mechanism induction verified, which might provide new method for

Language: Английский

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Pulsatilla saponin D inhibited the growth of osteosarcoma by regulating the JNK/ATF3 signaling pathway

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111420 - 111420

Published: Feb. 1, 2025

Language: Английский

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Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer

Journal of Complementary and Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract Fisetin, a flavonol belonging to the flavonoid subclass, is ubiquitous dietary present in fruits and vegetables, including fruit peels, has proven potential for anticancer activity, especially lung cancer – leading cause of cancer-related deaths globally. The current paper provides most detailed elaborate list various roles fisetin experimentally induced cells, these include promotion apoptosis, inhibition cell proliferation, migration, invasion, as well regulation autophagy. Among molecular targets, some identified pathways, such PI3K/Akt, MAPK, NF-κB, that affects are crucial tumor formation, so it can be considered chemopreventive agent. Moreover, improves effectiveness conventional treatments chemo- radiosensitizer minimizes side effects. However, overall utility clinical use now somewhat restricted by its poor solubility short half-life. It predicted future development nanotechnologies drug delivery, nanoparticle encapsulation, might help solve difficulties. Further Preclinical investigations required uniformly determine safety, efficacy, standard dosage consumption therapy.

Language: Английский

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Potential role of thymoquinone to treat gastrointestinal cancers: insights into its molecular mechanisms

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

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Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.

Language: Английский

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The interplay between autophagy and programmed cell death in osteoarthritis: insights into mechanisms and therapeutic targets

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Language: Английский

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Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2 are Endogenous Regulators of CD71 and Their Ligands Induce Ferroptosis in Breast Cancer

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Ferroptosis is an iron-dependent cell death pathway that involves multiple genes including the transferrin receptor (TFRC/CD71), glutathione peroxidase 4 (GPX4) and SLC7A11. This study based on hypothesis orphan nuclear 4A1 (NR4A1) NR4A2 maintain low levels of ferroptosis in triple negative breast cancer (TNBC) cells bis-indole derived (CDIM) compounds act as NR4A1/2 ligands induce by enhancing CD71 expression. 1,1-Bis(3'-indolyl)-1-(3,5-disubstitutedphenyl)methane (DIM-3,5) analogs were investigated for their cytotoxicity effects NR4A1 regulated induction cytotoxicity, western blot RT-PCR. Several assays also determined enhanced lipoperoxidation, reactive oxygen species malondialdehyde formation TNBC cells. Knockdown NR4A1, NR4A2, Sp1 Sp4 was carried out RNA interference. Molecular mechanisms NR4A1/2-mediated regulation expression using CD71-luciferase promoter constructs, overexpression chromatin immunoprecipitation (ChIP) assays. Initial studies show DIM-3,5 inverse NR4A1/NR4A2 agonist downregulated pro-oncogenic responses/gene products both receptors induced ROS, lipoperoxide this accompanied indicators include decreased GPX4 SLC7A11 CD71. Induction CD71, important biomarker observed after treatment with analogs, knockdown or demonstrating coregulated receptors. Moreover, ChIP analysis indicated acted ligand-dependent cofactors Sp1/4-mediated a key NR4A1/2/Sp gene can be directly targeted agonists to

Language: Английский

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Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applications

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 187, P. 118055 - 118055

Published: April 26, 2025

Language: Английский

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Silibinin Induces Both Apoptosis and Necroptosis with Potential Anti-tumor Efficacy in Lung Cancer

Anti-Cancer Agents in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(18), P. 1327 - 1338

Published: July 29, 2024

The incidence of lung cancer is steadily on the rise, posing a growing threat to human health. search for therapeutic drugs from natural active substances and elucidating their mechanism have been focus anti-tumor research.

Language: Английский

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