Human milk oligosaccharide secretion dynamics during breastfeeding and its antimicrobial role: A systematic review DOI
Mohammed Al‐Beltagi

World Journal of Clinical Pediatrics, Journal Year: 2025, Volume and Issue: 14(2)

Published: March 18, 2025

BACKGROUND Human milk oligosaccharides (HMOs) are bioactive components of breast with diverse health benefits, including shaping the gut microbiota, modulating immune system, and protecting against infections. HMOs exhibit dynamic secretion patterns during lactation, influenced by maternal genetics environmental factors. Their direct indirect antimicrobial properties have garnered significant research interest. However, a comprehensive understanding dynamics their correlation efficacy remains underexplored. AIM To synthesize current evidence on lactation evaluate roles bacterial, viral, protozoal pathogens. METHODS A systematic search PubMed, Scopus, Web Science, Cochrane Library focused studies investigating natural synthetic HMOs, dynamics, properties. Studies involving human, animal, in vitro models were included. Data HMO composition, temporal patterns, mechanisms action extracted. Quality assessment was performed using validated tools appropriate for study design. RESULTS total 44 included, encompassing research. exhibited 2′-fucosyllactose (2′-FL) lacto-N-tetraose peaking early declining over time, while 3-fucosyllactose (3-FL) increased later stages. demonstrated through pathogen adhesion inhibition, biofilm disruption, enzymatic activity impairment. Synthetic bioengineered 2′-FL 3-FL, structurally functionally comparable to effectively inhibiting pathogens such as Pseudomonas aeruginosa , Escherichia coli Campylobacter jejuni . Additionally, synergistic effects antibiotics, enhancing resistant CONCLUSION vital defense, supporting infant targeting various Both hold potential therapeutic applications, particularly nutrition adjuncts antibiotics. Further research, clinical trials, is essential address gaps knowledge, validate findings, explore broader applicability improving neonatal health.

Language: Английский

Bioactive compounds in human milk DOI
Anthony E. Castro, Maria Sanchez-Holgado, Miguel Sáenz de Pipaón

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Purpose of review: Human milk is the optimal food choice for infants. Reviewing latest advances in research about human compounds and their effect on health helps understand benefits breastfeeding improves knowledge key bioactive nutrients that can be used to improve feeding during infancy, with short long-time effects health. Recent findings: In last years, it has been described how such as oligosaccharides, hormones, lipids, cellular components microbes play an important role infants’ health, reducing risk infectious, metabolic autoimmune diseases. The mechanisms transmission from mother infant these are not always well described, but there several lines biological beneficial effects. Summary: These findings may help maternal interventions, modifiable factors able modulate composition. They development formulas enhance nutritional plans. Also, identification isolation describe new ways supplementation.

Language: Английский

Citations

0
The Legacy of COVID-19 in Breast Milk: The Association of Elevated Anti-Inflammatory and Antimicrobial Proteins with Vaccination or Infection DOI Creative Commons
Felicia Trofin, Petru Cianga, Daniela Constantinescu

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 182 - 182

Published: March 11, 2025

Background: Breast milk is a rich source of antimicrobial and anti-inflammatory compounds, owing to its diverse array bioactive molecules. This study explores the presence activity natural agents in breast milk, particularly context SARS-CoV-2 pandemic. Materials Methods: samples were collected from 50 breastfeeding mothers, including those who had either been vaccinated against or recovered infection. These compared with control group consisting 10 unvaccinated mothers no history COVID-19. Key immune-regulatory proteins—lactoferrin, lactadherin, furin, tenascin C, granzyme B, chitinase 3-like 1—were quantified using Luminex multiplex analyzer. Results Discussion: All targeted biomarkers detected providing insights into immune profile transferred infants following COVID-19 infection vaccination. molecules highlight breastfeeding’s role passive immunity protection. The protein levels found be influenced by factors such as maternal inflammation, infant age, delivery mode, parity, emphasizing dynamic interaction between immunity, lactation biology, development. Conclusion: Breastfeeding serves powerful anti-SARS-CoV-2 defense mechanism, supported lactoferrin, reinforcing critical child health.

Language: Английский

Citations

0
Human milk oligosaccharide secretion dynamics during breastfeeding and its antimicrobial role: A systematic review DOI
Mohammed Al‐Beltagi

World Journal of Clinical Pediatrics, Journal Year: 2025, Volume and Issue: 14(2)

Published: March 18, 2025

BACKGROUND Human milk oligosaccharides (HMOs) are bioactive components of breast with diverse health benefits, including shaping the gut microbiota, modulating immune system, and protecting against infections. HMOs exhibit dynamic secretion patterns during lactation, influenced by maternal genetics environmental factors. Their direct indirect antimicrobial properties have garnered significant research interest. However, a comprehensive understanding dynamics their correlation efficacy remains underexplored. AIM To synthesize current evidence on lactation evaluate roles bacterial, viral, protozoal pathogens. METHODS A systematic search PubMed, Scopus, Web Science, Cochrane Library focused studies investigating natural synthetic HMOs, dynamics, properties. Studies involving human, animal, in vitro models were included. Data HMO composition, temporal patterns, mechanisms action extracted. Quality assessment was performed using validated tools appropriate for study design. RESULTS total 44 included, encompassing research. exhibited 2′-fucosyllactose (2′-FL) lacto-N-tetraose peaking early declining over time, while 3-fucosyllactose (3-FL) increased later stages. demonstrated through pathogen adhesion inhibition, biofilm disruption, enzymatic activity impairment. Synthetic bioengineered 2′-FL 3-FL, structurally functionally comparable to effectively inhibiting pathogens such as Pseudomonas aeruginosa , Escherichia coli Campylobacter jejuni . Additionally, synergistic effects antibiotics, enhancing resistant CONCLUSION vital defense, supporting infant targeting various Both hold potential therapeutic applications, particularly nutrition adjuncts antibiotics. Further research, clinical trials, is essential address gaps knowledge, validate findings, explore broader applicability improving neonatal health.

Language: Английский

Citations

0