Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1871(2), P. 167578 - 167578
Published: Nov. 19, 2024
Language: Английский
Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: 156, P. 104865 - 104865
Published: Jan. 2, 2025
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 21, 2025
λ-type carrageenan (λ-CAR) polysaccharides remain overlooked in the preparation of medical nanoparticles (NP) due to their unsuitable rheological properties and undesired biological effects, although they can also offer advantageous properties. To overcome these obstacles, oligosaccharide derivatives (λ-COS) have been successfully applied synthesis stable NP incorporating both, ferrite cores divalent manganese (Mn2+) releasable ions. The acute pro-inflammatory behavior anticoagulant activity native λ-CAR were significantly reduced case λ-COS NP, rendering possible use for applications. In vivo MRI studies mice showed that framework is promising two first partial Mn2+ release into plasma achieve intracellular Mn2+-based contrast myocardium imaging hepatobiliary system. Second, it serves as a novel sugar-based coating confers suitable pharmacokinetic making further targeted therapy
Language: Английский
Citations
0
Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964
Published: April 8, 2025
The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144228 - 144228
Published: May 1, 2025
Language: Английский
Citations
0
Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 464 - 464
Published: July 16, 2024
Measuring the viscosity of pharmaceutical dosage forms is a crucial process. Viscosity provides information about stability composition, release rate drug, bioavailability, and, in case injectable drug formulations, even force required for injection. However, measuring complex task with numerous challenges, especially non-Newtonian materials, which include most such as gels. Selecting appropriate shear critical. Since many systems highly temperature-dependent, stable temperature control necessary during measurement. Using microfluidics technology, it now possible to perform rheological characterization and conduct fast accurate measurements. Small sample volumes (even below 500 µL) are required, determination can be carried out over wide range rates. Nevertheless, application viscometers operating on principle not yet widespread. In our work, we compare results measurements taken microfluidic chip-based viscometer different (gels, solution) those obtained using traditional rotational viscometer, evaluating relative advantages disadvantages methods. The microfluidics-based method enables time- sample-efficient analysis examined forms.
Language: Английский
Citations
2
Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 157, P. 110440 - 110440
Published: July 19, 2024
Language: Английский
Citations
2
Recent Advances in Inflammation & Allergy Drug Discovery, Journal Year: 2024, Volume and Issue: 19(1), P. 5 - 17
Published: Aug. 7, 2024
Carrageenan, a naturally occurring polysaccharide derived from red seaweed, has been utilized extensively in the food industry as stabilizer, thickener, and emulsifier due to its unique gel-forming properties. This versatile compound exists various forms, including kappa, iota, lambda, each with distinct characteristics suitable for different applications. Its widespread use additive raised concerns regarding safety, particularly potential inflammatory effects on gastrointestinal tract. While carrageenan deemed safe consumption by regulatory agencies small amounts, studies have suggested association intestinal inflammation disturbances, susceptible individuals. Animal models, rodents non-human primates, employed investigate response induced ingestion. These models provided valuable insights into molecular mechanisms underlying pro-inflammatory At level, is believed trigger activating toll-like receptor 4 (TLR4) signaling pathways, leading production of cytokines recruitment immune cells site exposure. Furthermore, carrageenan-induced may disrupt barrier function, facilitating translocation luminal antigens exacerbating responses. review provides comprehensive examination current understanding carrageenan's role inflammation, encompassing diverse applications industry, safety concerns, experimental findings animal effects.
Language: Английский
Citations
1
Sustainability, Journal Year: 2024, Volume and Issue: 16(16), P. 7175 - 7175
Published: Aug. 21, 2024
This review details the extraction, characterization and utilization of seaweed-derived biopolymers for future packaging applications. The is contextualized within broader scope challenge plastic pollution current urgent need more sustainable materials. Macroalgae (or seaweed) has been highlighted as a promising source biopolymers, most commonly sodium alginate, agar carrageenan, reasons such rapid growth rate decreased environmental impact when compared with terrestrial plant life. Extraction methods detailed include traditional solvent-based extraction developments ultrasound-assisted microwave-assisted bead milling. additionally presents techniques pertinent in determining applicability these Properties key importance to development materials thermal properties, mechanical strength, barrier properties biodegradability are comparison conventional petroleum-based plastics. concludes by realistically identifying challenges faced implementing seaweed-based into structures, cost-effectiveness, scalability performance while suggesting directions mitigate issues improve commercial viability industry.
Language: Английский
Citations
1
Biopolymers and Cell, Journal Year: 2024, Volume and Issue: 40(3), P. 231 - 231
Published: Sept. 10, 2024
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1871(2), P. 167578 - 167578
Published: Nov. 19, 2024
Language: Английский
Citations
0