Mechanism and Therapeutic Targets of Circulating Immune Cells in Diabetic Retinopathy DOI Creative Commons
Bowen Zhao, Yin Zhao, Xufang Sun

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 210, P. 107505 - 107505

Published: Nov. 14, 2024

Diabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within retinal microenvironment. Typically, retina is considered as an immune-privileged organ, where circulating cells are restricted from entry under normal conditions. However, during progression DR, this privilege compromised breach barrier and infiltrate retina. Increasing evidence suggests that vascular neuronal degeneration in DR largely driven infiltration cells, particularly neutrophils, monocyte-derived macrophages, lymphocytes. This review delves into mechanisms therapeutic targets associated with these cell populations offering a promising innovative approach managing disease.

Language: Английский

Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols DOI Creative Commons

Raissa Bulaty Tauil,

Paula Takano Golono,

Enzo Pereira de Lima

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1354 - 1354

Published: Oct. 10, 2024

Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment

Language: Английский

Citations

8
Study on the Correlation between Tea and Diabetic Retinopathy DOI

进欣 冉

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(02), P. 790 - 797

Published: Jan. 1, 2025

Language: Английский

Citations

0
The global burden of blindness and vision loss caused by type 2 diabetes mellitus from 1990 to 2021 and projections to 2050: findings from global burden of disease 2021 DOI Creative Commons
Jiamin Cao, Xiajing Liu, Yongquan Zhang

et al.

Critical Public Health, Journal Year: 2025, Volume and Issue: 35(1)

Published: March 7, 2025

We aimed to analyze the global trends in burden of blindness and vision loss caused by type 2 diabetes from 1990 2050. Based on Global Burden Disease Study (GBD) 2021, prevalence years lived with disability (YLD) were analyzed age, sex, socio-demographic index (SDI) for 204 countries territories projections future 2021 There 5694156 (4498190–7112643) numbers 459976 (304429–661417) YLDs due at level 2021. The age-standardized rate was 65.7 (52.2–82), YLD 5.3 (3.5–7.6) all which exhibited increasing Regionally, highest observed Central Latin America (145.8, 116.7–179.6). Nationally, Palestine (265.2, 203.7–339) had rate. Compared males, rates higher females Most 21 GBD regions upward presented females, both sexes a during retrospective 30 years. Enhancing population screening, optimizing treatment strategies, such as improving retinal screening community-based disease education, are essential release burden, particularly high-risk groups.

Language: Английский

Citations

0
Mechanism and Therapeutic Targets of Circulating Immune Cells in Diabetic Retinopathy DOI Creative Commons
Bowen Zhao, Yin Zhao, Xufang Sun

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 210, P. 107505 - 107505

Published: Nov. 14, 2024

Diabetic retinopathy (DR) continues to be the leading cause of preventable vision loss among working-aged adults, marked by immune dysregulation within retinal microenvironment. Typically, retina is considered as an immune-privileged organ, where circulating cells are restricted from entry under normal conditions. However, during progression DR, this privilege compromised breach barrier and infiltrate retina. Increasing evidence suggests that vascular neuronal degeneration in DR largely driven infiltration cells, particularly neutrophils, monocyte-derived macrophages, lymphocytes. This review delves into mechanisms therapeutic targets associated with these cell populations offering a promising innovative approach managing disease.

Language: Английский

Citations

1