Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 11, 2025

This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine effectiveness specific nutritional strategies preventing and treating this obesity-linked Emerging evidence underscores benefits Mediterranean diet, low-carbohydrate diets, intermittent fasting reducing fat, improving insulin sensitivity, mitigating inflammation. Supplementing with vitamin E, omega-3 acids, silymarin can potentially reduce fibrosis promote health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, nutraceutical supplementation. Integrating these lifestyle modifications, including regular physical activity, offers comprehensive approach metabolic outcomes patients MASLD. Further research needed refine personalize therapeutic interventions.

Language: Английский

---

Weight loss, changes in body composition and inflammatory status after a very low-energy ketogenic therapy (VLEKT): does gender matter?

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 19, 2024

Abstract Background Considering differences in body composition and inflammatory status between sexes, as well recent recommendations advocating for personalized dietary approaches, this study aimed to explore how sex influences weight loss, changes composition, subjects with grade I II obesity undergoing a 45-day of the Very Low-Energy Ketogenic Therapy (VLEKT). Methods Participants (21 premenopausal females 21 males), included adhered VLEKT underwent assessments anthropometric parameters (weight, height, mass index—BMI –, waist circumference), via bioelectrical impedance analysis, measured by high sensitivity C-reactive protein (hs-CRP) levels at baseline post-intervention. Results At baseline, males did not differ BMI ( p = 0.100) hs-CRP 0.948). Males demonstrated overall larger benefits than from terms loss (Δ% − 11.63 ± 1.76 vs 8.95 1.65 kg, < 0.001), fat 30.84 12.00 -21.36 4.65 0.002), 41.42 21.35 22.38 17.30 mg/L, 0.003). Of interest, phase angle values are statistically improved compared female 17.11 9.00 7.05 3.30°, 0.001). Conclusion These findings underscore importance considering sex-specific responses treatment strategies, particularly interventions like VLEKTs. Graphical

Language: Английский

---

Global Burden of Metabolic Dysfunction-Associated Liver Disease, 2010 to 2021☆

JHEP Reports, Journal Year: 2024, Volume and Issue: 7(3), P. 101271 - 101271

Published: Nov. 14, 2024

This study used the Global Burden of Disease data (2010-2021) to analyze rates and trends point prevalence, annual incidence, years lived with disability (YLDs) for metabolic dysfunction-associated steatotic liver disease (MASLD) in 204 countries. Total numbers age-standardized per 100,000 population MASLD YLDs were compared across regions countries by age, sex, sociodemographic index (SDI). Smoothing spline models evaluate relationship between burden SDI. Estimates reported uncertainty intervals (UI). Globally, 2021, prevalence 15,018.1 cases (95% UI 13,756.5-16,361.4), incidence 608.5 (598.8-617.7), 0.5 (0.3-0.8) years. was higher men than women (15,731.4 vs. 14,310.6 population). Prevalence peaked at ages 45-49 50-54 women. Kuwait (32,312.2 people; 95% UI: 29,947.1-34,839.0), Egypt (31,668.8 29,272.5-34,224.7), Qatar (31,327.5 29,078.5-33,790.9) had highest 2021. The largest increases estimates from 2010 2021 China (16.9%, 14.7%-18.9%), Sudan (13.3%, 9.8%-16.7%) India (13.2%, 12.0%-14.4%). varied SDI, peaking moderate SDI levels. is a global health concern, Kuwait, Egypt, Qatar. Raising awareness about risk factors prevention essential every country, especially China, India, where are rapidly increasing. research provides comprehensive analysis MASLD, highlighting its rising particularly varying indices. findings significant both clinicians policymakers, as they offer critical insights into regional disparities burden, which can inform targeted intervention strategies. However, study's reliance on modeling available suggests cautious interpretation, further needed validate these clinical real-world settings.

Language: Английский

---

Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 143 - 143

Published: Dec. 31, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, ketogenic intermittent fasting, high fiber diets have demonstrated potential addressing dysfunction underlying this condition. The development progression of MASLD closely associated with taxonomic shifts gut microbial communities, relationship well-documented literature. Given importance primary treatment for MASLD, it important understand how microbiota their byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, changes conferred unhealthy patterns Western may induce dysbiosis influence through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, causing oxidative damage hepatocytes. Although emerging evidence has identified links between microbiota, significant gaps remain understanding specific roles, metabolite pathways, host interactions, causal relationships. Therefore, review aims provide mechanistic insights into role microbiota-mediated processes analysis both contribution pathophysiology. By better elucidating interplay nutrients, processes, onset work identify new opportunities targeted interventions treat efficiently.

Language: Английский

---

Lesson learned from bariatric surgery: Preventing intra- and perioperative complications in patients with obesity undergoing laparoscopic adrenalectomy: Role of ketogenic preoperative diet: A propensity score matching analysis of a single-center experience

Surgery, Journal Year: 2025, Volume and Issue: 181, P. 109147 - 109147

Published: Jan. 30, 2025

Laparoscopic adrenalectomy is the preferred surgical approach for adrenal resection. The simultaneous presence of obesity and subsequent liver steatosis may complicate procedure, increasing risk intra- perioperative complications. This study explores effectiveness a preoperative very low-calorie ketogenic diet in improving outcomes patients with undergoing laparoscopic adrenalectomy. A retrospective analysis was conducted on 70 from January 2021 to July 2024 at Bariatric Endocrine-Metabolic Surgery Unit, University Naples "Federico II." Among these, 54 body mass index ≥30 kg/m2 were divided into 2 groups: group A, which underwent 4-week diet, B, did not receive any dietary intervention. Propensity score matching used balance groups confounding factors. Furthermore, subanalysis between performed according right left Group had significantly reduced operative time (94.59 ± 54.11 minutes) compared B (129.22 51.06 minutes, P = .01). Additionally, exhibited fewer complications (P also associated significant reduction 31.74 1.31 29.05 0.99 .001) before surgery. Our suggests can improve scheduled glands supports integration interventions management Future research larger sample sizes randomized controlled trials recommended validate these findings optimize care protocols.

Language: Английский

---

Differential Impact of Maternal and Paternal Metabolic Syndrome on Offspring’s Cardiometabolic Risk Factors

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

This study compared the sex-specific influence of maternal and paternal metabolic syndrome on offspring using 2007–2020 Korean National Health Nutritional Examination Survey database. As a result, male fathers with presented increased blood glucose levels unfavorable lipid profiles, whereas female pressure, triglyceride levels, decreased HDL cholesterol levels. Maternal was associated adverse profiles in both sexes, along pressure males waist circumference systolic females. When parents had syndrome, adjusted odds ratios for most its components were significantly elevated offspring. Conversely, exhibited relatively less syndrome. The disparate transgenerational impact health by sexes emphasizes need screening management strategies families

Language: Английский

---

Prevalence and association of metabolism-associated steatotic liver disease across age groups and gender

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 103926 - 103926

Published: Feb. 1, 2025

Language: Английский

---

MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 855 - 855

Published: April 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Language: Английский

---

Ketogenic Diet in Steatotic Liver Disease: A Metabolic Approach to Hepatic Health

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1269 - 1269

Published: April 4, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic dysfunction worldwide, characterized by hepatic steatosis that may progress to nonalcoholic steatohepatitis and cirrhosis. Owing its strong association with metabolic disorders, current management focuses on weight reduction via lifestyle modifications. Recently, the very-low-calorie ketogenic diet (VLCKD) has emerged as promising intervention due potential for rapid loss in fat. This review aims evaluate clinical evidence regarding impact diets steatosis. We conducted an extensive MEDLINE literature search databases including PubMed, Scopus, Web Science up December 2024. Studies assessing effects or low-carbohydrate high-fat fat, evaluated imaging, histology, biochemical markers, were included. The analysis indicates significantly reduce fat content improve parameters, insulin sensitivity enzyme levels. Evidence further suggests substituting saturated fats unsaturated replacing carbohydrates proteins enhance these benefits. However, considerable variability exists among studies long-term data remain limited. Although short-term outcomes are encouraging, adverse such dyslipidaemia, gastrointestinal disturbances, transient 'keto flu' symptoms require careful monitoring. Future research should focus elucidating underlying mechanisms, optimizing dietary composition, safety establish robust strategy managing MASLD.

Language: Английский

---

Special correlation between diet and MASLD: positive or negative?

Cell & Bioscience, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 12, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic and systemic metabolic characterized by the presence of hepatic steatosis at least one cardiometabolic risk factor (CMRF). The pathogenesis MASLD involves multiple mechanisms, including lipid metabolism disorders, insulin resistance, inflammatory responses, hepato-intestinal axis dysfunction. Among these factors, diet serves as both an inducement potential remedy in disease's development. Notably, high-lipid exacerbates fat accumulation, oxidative stress, thereby promoting progression MASLD. Consequently, dietary induction models have become vital tools for studying pathological mechanisms MASLD, providing foundation identifying therapeutic targets. Additionally, we summarize effects optimization on elucidate role specific components regulating axis, metabolism, inhibiting responses. In conclusion, studies utilizing animal offer significant insights into therapy, particularly concerning regulation metabolism-related hepatoenteric axis-related signaling pathways well beneficial mechanism probiotics regulation. By understanding which different patterns affect can assess clinical applicability current strategies provide new directions research treatment aimed modification.

Language: Английский

---