Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial DOI Creative Commons
Amy Jennings, Oliver M. Shannon, Rachel Gillings

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 23, 2024

Abstract Background Despite an urgent need for multi-domain lifestyle interventions to reduce dementia risk, there is a lack of which are informed by theory- and evidence-based behaviour change strategies, no in this domain have investigated the feasibility or effectiveness maintenance. We tested feasibility, acceptability cognitive effects personalised theory-based 24-week intervention improve Mediterranean diet (MD) adherence alone, combination with physical activity (PA), older-adults at risk dementia, defined using cardiovascular score. Methods Participants ( n = 104, 74% female, 57–76 years) were randomised three parallel arms: (1) control, (2) MD, (3) MD + PA 24 weeks invited optional follow-up period active intervention. Behaviour was supported targets, web-based intervention, group sessions food provision. The primary outcome (MD levels), secondary outcomes included acceptability, function, cardiometabolic health (BMI 24-h ambulatory blood pressure) process measures. Results feasible acceptable intended number participants completing study. Participant engagement provision components high. There improved two groups compared control (3.7 points on 14-point scale (95% CI 2.9, 4.5) 48 (2.7 1.6, 3.7)). did not significantly objectively measured PA. Improvements general cognition (0.22 0.05, 0.35), memory (0.31 0.10, 0.51) select captured as underpinning physiological mechanisms observed weeks. Conclusions successful initiating maintaining dietary up 12 months resulted benefits. It provides framework future complex range well-being endpoints. Trial registration ClinicalTrials.gov NCT03673722.

Language: Английский

The role of the gut microbiota in neurodegenerative diseases targeting metabolism DOI Creative Commons
Yufeng Fu,

Zhongya Gu,

Huấn Cao

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Sept. 26, 2024

In recent years, the incidence of neurodegenerative diseases (NDs) has gradually increased over past decades due to rapid aging global population. Traditional research had difficulty explaining relationship between its etiology and unhealthy lifestyle diets. Emerging evidence proved that pathogenesis may be related changes gut microbiota’s composition. Metabolism microbiota insidious far-reaching effects on provides new directions for disease intervention. Here, we delineated basic diseases, highlighting metabolism in also focusing treatments NDs based microbiota. Our review provide novel insights neurodegeneration approach a broadly applicable basis clinical therapies diseases.

Language: Английский

Citations

1
Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial DOI Creative Commons
Amy Jennings, Oliver M. Shannon, Rachel Gillings

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 23, 2024

Abstract Background Despite an urgent need for multi-domain lifestyle interventions to reduce dementia risk, there is a lack of which are informed by theory- and evidence-based behaviour change strategies, no in this domain have investigated the feasibility or effectiveness maintenance. We tested feasibility, acceptability cognitive effects personalised theory-based 24-week intervention improve Mediterranean diet (MD) adherence alone, combination with physical activity (PA), older-adults at risk dementia, defined using cardiovascular score. Methods Participants ( n = 104, 74% female, 57–76 years) were randomised three parallel arms: (1) control, (2) MD, (3) MD + PA 24 weeks invited optional follow-up period active intervention. Behaviour was supported targets, web-based intervention, group sessions food provision. The primary outcome (MD levels), secondary outcomes included acceptability, function, cardiometabolic health (BMI 24-h ambulatory blood pressure) process measures. Results feasible acceptable intended number participants completing study. Participant engagement provision components high. There improved two groups compared control (3.7 points on 14-point scale (95% CI 2.9, 4.5) 48 (2.7 1.6, 3.7)). did not significantly objectively measured PA. Improvements general cognition (0.22 0.05, 0.35), memory (0.31 0.10, 0.51) select captured as underpinning physiological mechanisms observed weeks. Conclusions successful initiating maintaining dietary up 12 months resulted benefits. It provides framework future complex range well-being endpoints. Trial registration ClinicalTrials.gov NCT03673722.

Language: Английский

Citations

0