Research hotspots and trends in diabetes and insulin resistance: a bibliometric analysis DOI Creative Commons

Shaobo Zhang,

Huixin Yan, Di Cao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 16, 2024

Many previous studies explored the relationship between diabetes and insulin resistance (IR); however, addressing research gap where no bibliometric analysis had been conducted to summarize analyze these publications, we will undertake a comprehensive investigate current status emerging trends in publications examining association IR.

Language: Английский

The Function of Myostatin in Ameliorating Bone Metabolism Abnormalities in Individuals with Type 2 Diabetes Mellitus by Exercise DOI Creative Commons
Chenghao Zhong, Xinyu Zeng, Xiaoyan Yi

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 158 - 158

Published: Feb. 27, 2025

Purpose: The molecular mechanisms involved in bone metabolism abnormalities individuals with type 2 diabetes mellitus (T2DM) are a prominent area of investigation within the life sciences field. Myostatin (MSTN), member TGF-β superfamily, serves as critical negative regulator skeletal muscle growth and metabolism. Current research on exercise-mediated regulation MSTN expression predominantly focuses its role muscle. However, due to intricate multifaceted mechanical biochemical interactions between bone, precise by which exercise modulates enhance metabolic disorders T2DM necessitate additional exploration. objective this review is systematically synthesize evaluate development associated elucidate underlying influenced interventions, aiming offer novel insights theoretical recommendations for enhancing health through physical activity. Methods: Relevant articles Chinese English up July 2024 were selected using specific search terms databases (PubMed, CNKI, Web Science); 147 studies finally included after evaluation, reference lists checked other relevant research. Results: Myostatin’s heightened can impede various pathways, such PI3K/AKT/mTOR Wnt/β-catenin, hindering osteoblast differentiation mineralization. Additionally, it stimulate osteoclast resorption capacity facilitating Smad2-dependent NFATc1 nuclear translocation PI3K/AKT/AP-1-mediated pro-inflammatory factor thereby contributing disorders. Physical plays crucial ameliorating T2DM. Exercise activate pathways like Wnt/GSK-3β/β-catenin, suppressing myostatin downstream Smads, CCL20/CCR6, Nox4 target gene expression, fostering formation, inhibiting resorption, Conclusion: In context T2DM, has been shown exacerbate osteoblasts process mineralization while simultaneously promoting activity osteoclasts. interventions have demonstrated efficacy downregulating disrupting signaling

Language: Английский

Citations

1
Evaluating the Therapeutic Potential of Exercise in Hypoxia and Low-Carbohydrate, High-Fat Diet in Managing Hypertension in Elderly Type 2 Diabetes Patients: A Novel Intervention Approach DOI Open Access
Raquel Kindlovits, Ana Sousa, João L. Viana

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 522 - 522

Published: Jan. 30, 2025

Type 2 diabetes mellitus (T2DM) is a chronic condition marked by hyperglycemia, which can affect metabolic, vascular, and hematological parameters. A low-carbohydrate, high-fat (LCHF) diet has been shown to improve glycemic control blood pressure regulation. Exercise in hypoxia (EH) enhances insulin sensitivity, erythropoiesis, angiogenesis. The combination of LCHF EH may offer promising strategy for managing T2DM hypertension (HTN), although evidence remains limited. This study aimed assess the effects an eight-week normobaric intervention at 3000 m simulated altitude combined with on lipid profiles, inflammation, older patients HTN. Forty-two diabetic HTN were randomly assigned three groups: (1) group (control + exercise normoxia), (2) EH), (3) (EH+LCHF) Baseline measurements included systolic, diastolic, mean (SBP, DBP, MAP), inflammation biomarkers. Blood decreased after (p < 0.001), no significant differences between groups (SBP: p = 0.151; DBP: 0.124; MAP: 0.18). No observed profile or C-reactive protein levels > 0.05). Mean corpuscular hemoglobin (MCH) increased 0.027), while it EH+LCHF 0.046). Adding restricting carbohydrates did not provide additional benefits Further elucidation mechanisms underlying adaptations imperative. NCT05094505.

Language: Английский

Citations

0
Correction: Kindlovits et al. Eight Weeks of Intermittent Exercise in Hypoxia, with or without a Low-Carbohydrate Diet, Improves Bone Mass and Functional and Physiological Capacity in Older Adults with Type 2 Diabetes. Nutrients 2024, 16, 1624 DOI Open Access
Raquel Kindlovits, Ana Sousa, João L. Viana

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2681 - 2681

Published: Aug. 13, 2024

In the original publication [...]

Language: Английский

Citations

0
Optimizing the lifestyle of patients with type 2 diabetes mellitus - Systematic review on the effects of combined diet-and-exercise interventions DOI Creative Commons

Jessica Amerkamp,

Süleyman Benli,

Eduard Isenmann

et al.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

To investigate the effects of combined diet-and-exercise interventions in patients with type 2 diabetes mellitus (T2DM).

Language: Английский

Citations

0
Research hotspots and trends in diabetes and insulin resistance: a bibliometric analysis DOI Creative Commons

Shaobo Zhang,

Huixin Yan, Di Cao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 16, 2024

Many previous studies explored the relationship between diabetes and insulin resistance (IR); however, addressing research gap where no bibliometric analysis had been conducted to summarize analyze these publications, we will undertake a comprehensive investigate current status emerging trends in publications examining association IR.

Language: Английский

Citations

0